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J R Friedman

Publications and source records attributed to J R Friedman.

12 recordsLinked to original sources
PubMed1996

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

The KRAB repression domain is one of the most widely distributed transcriptional effector domains yet identified, but its mechanism of repression is unknown. We have cloned a corepressor, KAP-1, which associates with the KRAB domain but not with KRAB mutants that have lost repression activity. KAP-1 can enhance KRAB-mediated repression and is a repressor when directly tethered to DNA. KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRAB binding and corepression. We propose that KAP-1 may be a universal corepressor for the large family of KRAB domain-containing transcription factors.

Amino Acid Sequence↗
PubMed1994

Krüppel-associated boxes are potent transcriptional repression domains.

The Krüppel-associated box (KRAB) is a highly conserved, 75-aa region containing two predicted amphipathic alpha-helices. The KRAB domain is present in the amino-terminal regions of more than one-third of all Krüppel-class Cys2His2 zinc finger proteins and is conserved from yeast to man; however, its function is unknown. Here it is shown that the KRAB domain functions as a DNA binding-dependent transcriptional repressor when fused to a heterologous DNA-binding domain from the yeast GAL4 protein. A 45-aa segment containing one of the predicted KRAB amphipathic helices was necessary and sufficient for repression. Amino acid substitutions in the predicted helix abolished the repression function. These results assign a function, transcriptional repression, to the highly conserved KRAB box and define a minimal repression domain which may aid in identifying mechanisms of repression.

3T3 Cells↗
PubMed1993

Five techniques for single tooth replacement on endosseous root-form implants.

Internally hexed and threaded root-form implants provide the clinician with many new treatment options for single tooth restorations. Coupled with an interlocking hex on the abutment, they provide stability for single tooth restorations while maintaining the options of screw or cement retention. Five techniques for fabricating single tooth restorations are presented. Clinical and laboratory evaluations of implant angulation, quantity and quality of the gingival tissues, and limitations in vertical height are discussed in relation to design, abutment selection, and laboratory procedures for each restoration. These techniques permit design of each restoration to meet the unique anatomic, functional and esthetic needs. Both screw-retained and cement-retained abutments and prostheses are discussed.

Dental Abutments↗
PubMed1993

Single tooth replacement with a combined post-and-crown implant prosthesis: a case report.

A patient desiring restoration of an individual second molar requested an osseointegrated implant. However, this patient lacked sufficient vertical space to accommodate a cemented crown, and did not want to compromise the adjacent dentition. A combination post-and-crown prosthesis effectively restored function and clinically acceptable aesthetics for this patient. The techniques for fabrication and rationale for this type of prosthesis are discussed.

Adult↗
PubMed1989

Correlation of estimated renal function parameters versus 24-hour creatinine clearance in ambulatory elderly.

This study evaluates the correlation between estimated renal function parameters (ie, creatinine clearance by the Cockcroft-Gault and Lott-Hayton formulas, serum creatinine and blood urea nitrogen) and 24-hour creatinine clearance in 15 young and 15 elderly subjects. Correlation coefficients (r) for the elderly group comparing Cockcroft-Gault and Lott-Hayton against 24-hour creatinine clearance were 0.73 (P less than .005) and 0.60 (P less than .02) respectively, and r for the young subjects were 0.37 (P greater than .05) and 0.57 (P less than .05), respectively. In 13 elderly subjects with creatinine clearance of 60 mL/minute or less, four (31%) had blood urea nitrogen of 20 mg/dL or less and 13 (100%) had serum creatinine between 1.0-1.5 mg/dL. We conclude that the formulas of Cockcroft-Gault and Lott-Hayton are valid in ambulatory elderly patients who are functionally independent without severe underlying disease, have normal body weight and are not on medication affecting renal function. Furthermore, in this select elderly population, an apparently normal serum creatinine (1.0-1.5 mg/dL) and blood urea nitrogen (20 mg/dL or less) may frequently represent a 24-hour creatinine clearance of 60 mL/minute or less.

Adult↗
PubMed1989

Osseointegrated implants: five systems. The Core-Vent implant system.

The developmental concepts of the Core-Vent System have been shaped by a desire to provide practicing dentists with a user-friendly system of oral implantology and restorative procedures. By providing implants in varying diametres, lengths and designs with a simplified surgical protocol, a true system of fitting the implant to the patient, not the patient to the implant, has evolved to meet the clinical needs of both dentists and patient. Standardized prosthetics enable similar restorations to be performed on all implants in the system. Bendable titanium inserts and castable abutments allow the optimum achievement of esthetics, regardless of the angle of implant placement.

Dental Abutments↗
PubMed1985

Stereoacuity in patients with optic nerve disease.

Twenty-eight patients were given the Titmus stereoacuity test (TST). Seventeen patients had documented optic nerve disease, and 11 had no known optic nerve disease. Thirteen of 17 patients (76%) with known optic nerve disease failed to achieve their expected TST scores, while only three of 11 (27%) of the patients without optic nerve disease fell into this category. Patients with reduced visual acuity secondary to optic nerve disease showed a disproportionately greater reduction in their TST scores than would be expected, based on Snellen's visual acuities.

Adult↗