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Biomedical subjects

J R GOODMAN

Publications and source records attributed to J R GOODMAN.

At least 19 recordsLinked to original sources
PubMed1963

COUMARIN THERAPY. PROTHROMBIN ACTIVITY AFTER TERMINATION OF TREATMENT.

Twelve patients receiving coumarin type hypoprothrombinemic agents were studied before, during and after termination of therapy, the prothrombin proconvertin method having been used to assay the prothrombin activity complex. In no instance was post treatment "rebound" demonstrated. Prothrombin activity levels returned to pretreatment values only after ten days following termination of coumarin or Dicumarol administration. If a reactivation of thrombotic tendency occurs following discontinuance of anticoagulant therapy, it would not appear to be related to a "rebound" of prothrombin activity above that which is "normal" for the individual patient. Patients tend to return to the same level of prothrombin activity present before initiation of coumarin therapy.

Anticoagulants↗
PubMed1962

Decrease in serum cholesterol with surgical stress.

Serum cholesterol levels decreased with the stress of operation, before the procedure or after it, or before and after. This decrease was 17.6 per cent in a group of 28 elective surgery patients and 20.4 per cent in nine ruptured intervertebral disc patients who had an operation. A presurgical drop was noted and considered to be related to psychological stress.

Cholesterol↗
PubMed1955

The glomerulus in experimental renal disease in rats as observed by light and electron microscopy.

Nephrotoxic serum disease in rats has been studied by light and electron microscopy from 1 hour to 10 weeks after production of the disease. By light microscopy leucocytic infiltration of the glomerular capillary was observed between the 3rd and 6th hour. At 6 hours an increase in colloidal iron-positive material was observed coating the extraluminal surface of the capillaries. Also at this time swelling of the endothelial cells becomes prominent. By 72 hours, thickening of the basement membrane was observed. Glomerular capillary thrombi were observed in approximately half the tissue examined in the first 2 weeks of disease. 50 per cent of the animals showed severe chronic lesions, exudation into the capsular space, crescent formation, and obliteration of glomeruli. At 1 hour electron microscopic pictures showed that osmophilic material may line the foot processes of the epithelial cells and obliterate all but narrow channels of the space between the feet. By 6 hours thickening of the basement membrane was prominent. This change persisted throughout 10 weeks of observation. The tissue from animals which had severe chronic alterations by light microscopy revealed changes which could not be interpreted at this time.

Animals↗