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Biomedical subjects

J R Glassburn

Publications and source records attributed to J R Glassburn.

15 recordsLinked to original sources
PubMed1996

Intracavitary use of radioactive colloidal phosphorus 32 in the treatment of epithelial ovarian cancer.

The use of radioactive colloidal phosphorus 32 (32P) in the treatment of epithelial ovarian cancer continues to be controversial. One institution's experience with the use of 32P in 30 patients with epithelial ovarian cancer was reviewed retrospectively. One hundred percent of attempts at placement of 32P intra-abdominally were ultimately successful. The complication rate was 11%. Mean clinical (asymptomatic) disease-free survival in patients with stage III ovarian cancer was as follows: 26 months based on absence of disease at reassessment surgery; 26 months based on microscopic residuum; and 30 months based on minimal (< 5 mm) residuum. Mean disease-free survival in patients with early-stage (stages IC through IIC) ovarian cancer was 66 months.

Brachytherapy↗
PubMed1984

Radiation therapy for metastatic disease involving the orbit.

A series of 47 patients with clinically demonstrated metastatic disease to the eye were evaluated for treatment with radiation therapy. Of the 37 patients who completed treatment, 88.9% responded with demonstrated tumor regression and improvement of symptoms. The breast and lung remain the two most common sites of origin for metastatic disease involving the orbit although the reason for this remains undetermined. The most common site of orbital involvement is the posterior choroid and no predilection for involvement of either the right or left eye could be determined. Radiation doses in the range of 3000-4000 rad delivered over a 3- to 4-week period of time, with care being taken to spare the lens, is recommended. Aggressive radiation therapy is indicated when the eye metastasis occurs without systemic disease or with stable systemic disease. The median survival in this group of patients was 8.5 months in those patients in whom adequate follow-up information was available.

Adolescent↗
PubMed1981

Carcinoma of the endometrium.

Controversy continues as to how and when radiation therapy can best be combined with surgery in order to improve treatment results in patients, with endometrial cancer. Various prognostic factors--tumor grade, depth of myometrial invasion, size of the uterine cavity, and the presence of nodal or parametrial spread--must all be considered when planning therapy. Well-differentiated Stage IA endometrial cancers hav an excellent prognosis when treated by surgery alone. Evidence suggests, however, that all other Stage I tumors benefit from combined radiation and surgical treatment. Patients with advanced stages of disease are candidates for combined surgery and radiation or radiation alone, owing to the high frequency of pelvic node involvement. Areas of active investigation include the addition of systemic therapy in patients with Stage III disease and the evaluation of extended field radiation in patients with histologically confirmed high pelvic or paraaortic nodal involvement.

Brachytherapy↗
PubMed1981

Management of carcinoma of the uterus stage II.

A total of 34 patients with Stage II endometrial carcinoma were evaluated for treatment in the department of Radiation Therapy at Hahnemann Medical College and Hospital from January 1958 to December 1977. Nineteen patients were treated by a standard radiation therapy technique using two radium placements and external beam therapy designed to give a high central tumor dose and also to give adequate radiation to the pelvic lymph nodes. A second group of 15 patients was treated by a wide variety of treatment programs, in most cases a combination of radiation and surgery. No significant difference can be seen between the results in the two groups. Excellent local control was obtained with one failure in each group. The high rate of distant failure indicates inaccuracies in the clinical staging and the diagnostic work-up methods available during this time. A more extensive pretreatment work-up utilizing computerized tomography, lymphangiography, or surgical exploration might improve the clinical staging and allow individualization of the treatment program.

Adenocarcinoma↗
PubMed1979

Whole abdominal irradiation for carcinoma of the ovary.

A selected group of 39 patients with ovarian carcinoma were treated by whole abdominal radiation therapy with a pelvic boost. No statement as to the efficacy of this treatment program can be made for patients with Stage I, II, and IV disease because of the small number of patients with those stages who were treated by this method. A surprising 30% 5-year survival was obtained, however, in patients with Stage III disease. The challenge of ovarian carcinoma lies in the advanced stage of disease in most patients at the time of diagnosis.

Adult↗
PubMed1977

Hyperbaric oxygen in radiation therapy.

The importance of oxygen with low LET radiations has been established beyond any doubt in many different systems, both plant and animal. While some studies, especially head and neck tumors, are impressive, it has not been demonstrated unequivocally that radiation under hyperbaric conditions is superior to well fractionated, well conceived, conventional radiotherapy. Any resulting gain in survival from the addition of hyperbaric oxygen will be limited, especially with more advanced stages of disease. Well controlled studies, especially with earlier stage disease, are still necessary. It would be worthwhile to undertake such trials, especially with tumors of the head and neck constituting the most promising site of study, as others have noted, since even a 5% to 10% improvement in survival would mean many lives saved. Continued trials with hyperbaric oxygen, oxygen in other forms, neutrons and other particles, and radiation sensitizing drugs are all justified in an attempt to overcome the oxygen effect on human tumors.

Animals↗
PubMed1976

Subtotal mastectomy and radiation therapy in the definitive management of localized breast malignancy.

Between 1961 and 1974, 51 women with primary carcinoma of the breast were treated by external radiation following surgery that was limited to diagnostic biopsy. All patients tolerated therapy well with minimal long term morbidity. While the reported follow-up periods are brief (most patients at risk for less than 3 years), 29 patients remain alive, 25 of whom show no evidence of persistent or recurring disease. These data suggest that local-regional control rates match those obtained following mastectomy. Definitive statements as to local failures and long term survival rates are not yet available.

Adult↗