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Biomedical subjects

J R Gleason

Publications and source records attributed to J R Gleason.

33 records · Page 2Linked to original sources
PubMed1993

Olfactory bulbectomy in rats modulates feeding pattern but not total food intake.

The role of olfactory input in the regulation of food intake and feeding patterns in rats was investigated by performing bilateral olfactory bulbectomy. Compared to control rats, bulbectomized rats ate the same amounts of food, but did so via a decrease in meal size, and a doubling in meal number. Although no increase in meal duration occurred, the exploratory behavior of sniffing during meals and between meals also increased significantly. While it is not yet clear how the olfactory bulbs participate in regulating food intake configuration resulting in changed feeding patterns, their clinical role can be appreciated by observing the acute changes in feeding pattern that occur when their input to the lateral hypothalamic area is damaged experimentally.

Animals↗
PubMed1993

Case report: an unexpected intravenous pyelogram appearance in an azotemic patient.

The authors discuss the unusual intravenous pyelogram (IVP) findings in a patient with blunt abdominal trauma. Although the patient had apparent renal dysfunction, both nephrogram and pyelogram were seen clearly after a moderate dose of iothalamate. This may be explained by the fact that the underlying complete obstruction was relieved by his traumatic bladder rupture, prior to the contrast study. Alternatively, evidence of azotemia may be an artifact, resulting from resorption of urea and creatinine after rupture. Thus, the nephro-pyelogram may accurately reflect his renal function.

Abdominal Injuries↗
PubMed1993

Parenteral nutrition, brain glycogen, and food intake.

To determine whether brain glycogen concentrations change during parenteral nutrition, Fischer 344 rats with jugular vein catheters received 0.9 N saline or parenteral nutrition providing 100% of daily calories (PN-100). Rats were killed after 4 days of PN-100 and serially after PN-100 was stopped. Food intake decreased during PN-100 to approximately 15% of control, but total kilocalories eaten and infused over the 4-day PN-100 period was approximately 130% of control. Food intake of PN-100 rats remained low for 3-4 days post-PN-100. At the end of the 4-day PN-100 period, plasma glucose and insulin (P = 0.01) and whole brain glycogen (P < 0.005) were higher than but similar to control within 24 h of PN-100 being stopped. When PN-100 rats were not allowed to eat during the infusion period, plasma glucose was lower, plasma insulin higher, and brain glycogen content the same as in control rats after 4 days of PN-100. The increased brain glycogen was the likely consequence of the hyperglycemia and hyperinsulinemia during PN-100 and was not causally associated with the reduced food intake either during or immediately after PN-100.

Animals↗
PubMed1992

Influence of anterior subdiaphragmatic vagotomy and TPN on rat feeding behavior.

Total parenteral nutrition (TPN) inhibits food intake and feeding behavior. Whether caloric sensory function of the liver contributes to this food intake and feeding behavior regulation via vagal-afferent innervation was tested after performing anterior hepatic vagotomy or sham operation in rats infused with a TPN solution providing 100% of daily energy needs, given continuously for 4 days. Food intake, meal number, size, duration, meal and intermeal sniffs, and eating activity were measured using an automated computerized rat eater meter (ACREM). TPN infusion resulted in a significant decrease of food intake and feeding indexes in both groups. The vagotomized rats showed a significantly higher food consumption, achieved by greater meal frequency, larger meal size, and longer meal duration. Thus, vagotomized rats consumed more than their controls by eating larger meals more often and of longer duration. Data suggest that anterior hepatic vagotomy interrupts hepatic caloric sensory feedback loop, diminishing inhibitory vagal effects on food intake with TPN, leading to an overall increase in food intake.

Afferent Pathways↗
PubMed1991

Change in meal size, number and duration after neural isolation of liver and with TPN.

The abundant neural connections between the liver and hypothalamus suggest that the liver contributes to spontaneous food intake (SFI) regulation. This hypothesis was tested in rats after total liver denervation (TLD) and infusing TPN. A sham operation (SO) or TLD was performed in Fischer rats, placed in metabolic cages fitted with an Eater Meter to measure SFI, meal number (MN), size (MZ), and duration (MD). Rats had free access to chow and water. After 22 days, a jugular catheter was placed and normal saline continuously infused for 10 days (days 22-32). Then TPN-100, providing 100% of rats daily energy needs, was infused for 3 days (days 32-35). During the post-SO/TLD and postjugular catheterization periods and during TPN-100, SFI was the same in SO controls and TLD group. However, TLD rats had decreased MZ and MD (interpreted as early satiety) and increased MN (interpreted as increased hunger) to maintain the same SFI as control rats. Although total SFI was not influenced by TLD, it significantly affected feeding pattern, suggesting that the neural isolation of the liver from the brain produces altered hypothalamic regulation of not only the onset of feeding, but also satiety.

Animals↗
PubMed1991

Effects of continuous graded total parenteral nutrition on feeding indexes and metabolic concomitants in rats.

The influence of graded amounts of total parenteral nutrition (TPN) on food intake and feeding indexes was investigated in 90 rats housed in Automated Computerized Rat Eater Meter metabolic cages with free access to water and chow. When food intake was stable after catheter placement, 10 control rats continued with the 3 ml/h normal saline used for catheter patency, whereas study rats were given graded TPN continuously for 3 days, amounting to the equivalent of 26% (TPN-26), 53% (TPN-53), 81% (TPN-81), or 114% (TPN-114) of their daily caloric needs. TPN consisted of glucose, fat, and amino acids in the caloric ratio of 50:30:20. In study rats, the graded TPN depressed food intake, meal number, meal size, and eventually food consumption rate, meal sniffs, and intermeal sniffs in a dose- and time-dependent manner. During graded TPN, rats decreased total food intake by eating fewer, smaller, shorter meals at a decreasing consumption rate; sniffing activities were correspondingly curtailed. Stopping TPN led to normalization of feeding indexes. Blood glucose did not change while plasma insulin rose with graded TPN. A decrease in hepatic glycogen and an increase in hepatic triglycerides occurred. Plasma valine, phenylalanine, and methionine rose in a TPN dose-dependent manner. TPN-26 and TPN-53 significantly decreased whole brain amino acids; with TPN-114 no change occurred. Brain influx of tryptophan remained unchanged, but a progressive decrease in brain influx of tyrosine occurred. Whole brain dopamine and serotonin were depressed with TPN-26 and TPN-81 but were normal with TPN-114.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMed1990

Quantifying language development from birth to 3 years using the Early Language Milestone Scale.

A point-scoring technique for the Early Language Milestone Scale is described. Normative data based on the original 1982 cross-sectional sample and validation data based on a separate longitudinal sample are presented. Mean Early Language Milestone Scale point scores, standard deviations, and percentile equivalents for raw point scores are presented for all ages from birth to 36 months. Correlations between point scores on the Early Language Milestone Scale and scores on other standardized developmental tests such as the Stanford-Binet Intelligence Scale, the Peabody Picture Vocabulary Test, and the Illinois Test of Psycholinguistic Abilities are presented. The clinical and research advantages of this point-scoring technique are presented and compared with the original pass/fail scoring method.

Child, Preschool↗
PubMed1988

Selected temporal aspects of coordination during fluent speech of young stutterers.

The purpose of this study was to compare the onsets, offsets, and durations of respiratory, articulatory, and laryngeal behaviors associated with the perceptually fluent speech of young stutterers (n = 8) to those of their normally fluent peers (n = 8). Simultaneous recordings of the targeted behaviors were made using noninvasive, minimally intrusive instrumentation. Specific temporal parameters of coordination--onsets, offsets, and durations of muscle activity and structural movement--were assessed within a particular component of the speech production system (e.g., onset of lower lip closing relative to lower lip opening muscle activity) as well as between different components (e.g., onset of rib cage deflation relative to onset of vocal fold contact for voicing). Results indicated that there were neither statistically significant nor apparent differences between the perceptually fluent speech of young stutterers and that of their normally fluent peers in terms of selected temporal characteristics of coordination. Findings suggest that the molar temporal characteristics of coordination for young stutterers' fluent speech production(s) are not appreciably different from those of their normally fluent peers and further, any temporal characteristics of stutterers' fluent speech that do differ from normal are probably brief, as well as subtle, in nature.

Child, Preschool↗
PubMed1988

Unclear speech: recognition and significance of unintelligible speech in preschool children.

Clarity of speech normally improves throughout the first few years of life, with acquisition of complete intelligibility by 4 years of age. Delayed emergence of intelligibility, or frankly unintelligible speech, often signify the presence of a major disturbance of language, overall cognitive development, or hearing. Norms are provided for the ages by which a child should be 50%, 75%, and 100% intelligible to strangers, and a new technique for screening intelligibility of speech is described. Data validating this technique are presented, and the developmental implications of unintelligible speech are reported. The importance of screening for intelligibility of speech is emphasized, in light of the findings presented.

Articulation Disorders↗
PubMed1982

Validation of an early language milestone scale in a high-risk population.

Detailed language evaluations were obtained by interviewing the parents of 191 healthy children aged 0 to 3 years, and by testing the children themselves. From these data, normative values were derived for 41 language milestones in the first 36 months of life. These values were used to construct the Early Language Milestone Scale (ELM Scale), a brief language assessment tool suitable for use by general pediatricians. Physician use of the ELM Scale in a population of 119 children considered at high risk for the presence of developmental disability yielded 97% sensitivity and 93% specificity for the ELM Scale as a detector of developmentally delayed children, when compared with more formal developmental measures as applied by a clinical psychologist or speech pathologist. Early language milestones are a sensitive indicator of developmental integrity; delayed achievement of early language milestones strongly suggests the presence of a significant underlying developmental disability. The ELM Scale may be adopted as a valid measure of developmental status among children considred at high risk for the presence of developmental disabilities.

Cerebral Palsy↗
PubMedDate not supplied

Test-retest and interobserver reliability of the Early Language Milestone Scale, second edition.

Test-retest and interobserver reliability are reported for the Early Language Milestone Scale, second edition, a language assessment tool for infants and children from birth to 36 months of age. Reliability data are presented for two scoring methods: the pass-fail method that yields a global rating of "pass" or "fail," and the point-scoring method that yields percentile scores. Both scoring methods showed good reliability. The clinical applicability of each scoring system is discussed.

Child, Preschool↗
PubMedDate not supplied

Effect of estradiol and progesterone on daily rhythm in food intake and feeding patterns in Fischer rats.

The product of meal number x meal size, over time, is food intake. Because estrogens modulate feeding activity via their action on the hypothalamus, and because there is a diurnal rhythm in the expression of cytoplasmic estrogen receptors and in estrogen binding activity, the present study examined the effects of ovariectomy and later hormone therapy on acute changes in body weight, and on the meal number-to-meal size relationship as reflected by food intake in the dark/light feeding patterns, in adult female rats in the intact state and after ovariectomy. Twelve female Fischer rats were randomized into ovariectomy and sham operation groups. A rat eater meter measured the feeding indexes for 15 days before and 25 days after ovariectomy, and later for 35 days with hormone therapy. We report: (a) mean body weight gain was linear before and up to ovariectomy, while exponential after ovariectomy; (b) increase in daily food consumption is mainly via an increase in food intake during the light phase; (c) light phase meal number remains unchanged, meal size significantly increases, with the resultant increase in overall food intake; (d) during the dark phase, meal size also significantly increases, but is accompanied by a proportional decrease in meal number, resulting in unchanged dark-phase food intake; and (e) estrogen restoration with either estradiol valerate or estradiol-progesterone combination, reversed the above changes. Data show that in the female Fischer 344 rat: (a) changes in daily rhythm in food intake are brought about by differential effects of the hormones on both meal size and meal number in both the total daily levels as well as in the dark-to-light distribution; (b) estadiol appears to have a tonic inhibitory effect on the light phase meal size and a phasic effect on the dark phase meal size and number, but no significant effect on the light-phase meal number; and (c) in the Fischer rats, progesterone augments estradiol's effect on these indicies.

Animals↗
PubMedDate not supplied

Differential feeding patterns induced by tumor growth and by TPN.

The effects of anorexia induced by early tumor, and anorexia induced by total parenteral nutrition (TPN) on food intake and the indexes of food intake, were investigated in rats infused with saline after jugular catheter placement and concomitant inoculation with methylcholanthrene (MCA)-induced tumor cells on day 0, and in rats without catheters receiving tumor only. Tumor became palpable around day 10 and increased to represent 6-8% of host body weight by day 26. On day 18, food intake started to decrease. Catheter-bearing rats were then randomized to saline controls (n = 9) for 11 d or to TPN-100 (n = 9) for 4 d providing 100% of daily caloric needs. Both then received saline until day 26. Food intake and feeding indexes were continuously measured using the Automated Computerized Rat Eater Meter (ACREM) and data was analyzed using ANOVA and regression analysis. In controls (both with and without catheter) the tumor induced a specific feeding pattern which consisted of a significant (P < 0.01) decrease in food intake via a significant (P < 0.05) decrease in meal size. A non-significant decrease in meal number and meal duration occurred. Two other feeding-related activities, meal consumption rate and intermeal sniffs, also decreased. Infusion of TPN-100 into the already anorectic rat led to a further significant (P < 0.0001) decrease in food intake via a significant decrease in both meal size (P < 0.0001) and in meal number (P < 0.0001). A decrease in all other feeding indexes also occurred, resulting in a different feeding pattern. After stopping TPN-100, the TPN-100-induced feeding pattern returned to that of the tumor-induced feeding pattern. That the tumor-induced feeding pattern differs from the TPN-100-induced feeding pattern suggests that the mechanisms whereby these two factors induce anorexia may also differ.

Animals↗
PubMedDate not supplied

Densitometry-based equations for estimating body composition in Fischer rats.

Male Fischer rats are widely used to evaluate the effects of nutritional repletion or deprivation on the rat's nutritional status. Practical methods are needed to evaluate changes in body composition. Chemical analysis is expensive, time consuming, and often not available; bioelectrical impedance analysis in laboratory animals lacks standardization. Postulating that the measurement of densitometry would allow reliable estimation of body composition in the male Fischer rat, we studied 27 male Fischer rats. Densitometric measurements of the carcasses and their chemical analysis were performed to obtain reference values. Initial estimation of the fraction of body fat based on densitometry was attempted with the Siri equation intended for use in humans. We found that this equation was not suitable for use in the male Fischer rat because it underestimated fat mass at high carcass weights and overestimated fat mass at low carcass weights. Therefore, the Siri equation was modified to more accurately predict carcass composition in the male Fischer rat. Three different predictive equations based on simple densitometric measurements were developed that allow separate estimation of carcass fat, carcass water, and carcass protein in the male Fischer rat. These equations were found to be accurate to within 2-5-3% of carcass weight.

Adipose Tissue↗