PubMed Health⌕ Search

Biomedical subjects

J R Goepel

Publications and source records attributed to J R Goepel.

At least 55 records · Page 3Linked to original sources
PubMed1989

Basosquamous carcinoma, a wolf in sheep's clothing? Report of 3 cases.

Basosquamous carcinoma of the skin is a lesion with specific histological features and recognized metastatic potential. Three cases of metastatic basosquamous carcinoma are reported, two of which were rapidly fatal. They illustrate that diagnostic features may be absent in a small biopsy and that metastasis is usually associated with a poor prognosis.

Aged↗
PubMed1988

Comparison of excision versus cryosurgery of an HSV-2-induced fibrosarcoma. I. Survival, extent of metastatic disease and host immunocompetence following surgery.

Cryosurgery and excision were used to treat primary tumours of HSV-2-transformed hamster tumour sublines, and post-operative survival and the extent of metastatic disease were compared in the two groups. An inferior prognosis was observed following cryosurgery although the extent of metastatic disease was similar in both groups. Using this model it would appear that cryosurgery enhances the development of micrometastases rather than affecting the number of cells shed from the primary tumour during surgery. To investigate the underlying causes of the decrease in survival following cryosurgery, in vitro assays were used to monitor host immunocompetence following surgery. The results showed that whilst natural killer cell cytotoxicity was only marginally depressed, mitogen responsiveness and lymphocyte participation in a mixed lymphocyte reaction were severely reduced 3-7 days post-cryosurgery. In parallel with immunosuppression, extensive cell proliferation in the spleen of cryosurgically treated tumour-bearing animals was observed. Histological examination of the spleen demonstrated the presence of large numbers of transformed cells which correlated with the loss of mitogen responsiveness and the ability to participate in a mixed lymphocyte reaction. Further studies (manuscript submitted for publication) have demonstrated that spleen cells from animals whose tumour is treated by cryosurgery are capable of suppressing immunocompetence in vitro, implying they have a role in the uncontrolled growth of micrometastases in vivo.

Animals↗
PubMed1988

Metastatic teratoma associated with an intra-abdominal abscess.

A case of metastatic testicular teratoma is reported where histological evidence of metastatic disease was obtained 12 years after orchidectomy. The patient had presented again 2 years earlier but the presence of a large intra-abdominal abscess delayed the diagnosis of recurrence. At no time were the serum levels of alpha-fetoprotein or beta human chorionic gonadotrophin elevated.

Abscess↗
PubMed1988

Immunohistological demonstration of progesterone receptor in breast carcinomas: correlation with radioligand binding assays and oestrogen receptor immunohistology.

The validity of determining the progesterone receptor status of breast carcinomas with a monoclonal antibody was investigated by comparison with data from a radioligand binding assay on adjacent cryostat sections of 103 tumours. Significant nuclear staining for progesterone receptor was observed in 37 (36%) of the tumours studied and this showed a close correlation with the results of radioligand binding assays for progesterone receptor. In three progesterone receptor positive tumours there was an apparent paradoxical absence of oestrogen receptor; progesterone receptor normally depends on the presence of oestrogen receptor, but these rare tumours may be essentially progesterone receptor positive. It is concluded that this monoclonal antibody is an appropriate reagent for use in the immunohistological determination of progesterone receptor status of breast carcinomas; that it advantageously identifies both the occupied and unoccupied receptor sites; and that it provides information about tumour cell heterogeneity with respect to receptor status.

Antibodies, Monoclonal↗
PubMed1987

The effect of the immune status of the TAR mouse on the growth and metastasis of tumour xenografts.

Mice thymectomised at 3-4 weeks of age and subsequently given whole-body irradiation (9 Gy) under cytosine arabinoside cover (TAR mice) provide an alternative model to the athymic nude (nu+/nu+) mouse for studying the biological characteristics of tumour xenografts. In the present study we have evaluated the repopulation events in the bone marrow and spleen following whole body irradiation of TAR mice, and analysed immune competence up to 98 days following irradiation. Repopulation of both bone marrow and spleen was evident in the weeks following whole body irradiation, and an initial increase in the relative proportion of T-lymphocytes present in the spleen was followed by a decrease in the percentage of lymphocytes expressing T-cell markers, which remained below the level observed in control mouse spleen cell preparations. TAR mice exhibited a decreased ability to respond to a non-specific T-cell mitogen and to elicit a T-cell dependent antibody response to influenza viral antigen. Both TAR and control mice possessed macrophages which could be activated to the tumouricidal state, and natural killer activity of TAR mice was enhanced greater than 3-fold above control values. The ability of TAR mice to accept tumour xenografts decreased with the increasing time interval between irradiation and subcutaneous implantation of tumour cells, and (in some instances) spontaneous regression was observed. In addition, a hamster tumour cell line possessing high metastatic potential in its syngeneic host was shown to metastasise to the regional lymph node, lungs, liver, kidneys and spleen of TAR mice from a cell inoculum implanted subcutaneously immediately after irradiation; however, with increasing time between irradiation and inoculation of tumour cells tumour metastasis decreased. The ability of TAR mice to support the growth and metastasis of tumour xenografts would appear to inversely correlate with the increase in natural killer cell activity following irradiation.

Animals↗
PubMed1986

Giant vascular eccrine spiradenomas: a report of two cases with histology, immunohistology and electron microscopy.

Two examples of a variant of benign spiradenoma are reported, both characterized by their large size and high degree of vascularity. The results of studies using light microscopy, transmission electron microscopy and immunohistology are described. The relationship of this unusual variant to other spiradenomas and their eccrine sweat gland origin is discussed. The possible misdiagnosis of this rare type of spiradenoma is emphasized.

Adenoma, Sweat Gland↗
PubMed1985

Extranodal lymphoma of the head and neck: a review of 49 consecutive cases.

One thousand and two consecutive patients with lymphoma were referred to the Regional Radiotherapy and Oncology Centre at Weston Park Hospital, Sheffield from 1970 to 1982 inclusive. Four hundred and seventy (47%) of the lymphomas occurred in the head and neck and 49 (10.4%) of these were extranodal. These 49 patients with primary extranodal lymphoma of the head and neck were reviewed with regard to clinical presentation, histological grade, treatment and survival. The specialists involved in the initial diagnosis were, in order of frequency, ear, nose and throat surgeons, general surgeons, ophthalmic surgeons and oral surgeons. Tonsillar and thyroid lymphomas occurred most frequently and constituted 71.0% of this series. All extranodal lymphomas were non-Hodgkin's lymphomas and two-thirds were graded as histologically unfavourable. Clinical staging showed that 65% of tonsillar lymphomas had local lymph node involvement at the time of diagnosis (Stage II); only 25% of lymphomas from other sites were Stage II. Radiotherapy was the primary treatment and was associated with a cumulative survival rate of 46.5%. Most recurrences were within 1 year and at distant sites. Recurrent disease had a poor prognosis with only 10% achieving lasting remission. Further analysis of cumulative survival after 6 years showed 65.7% for clinical Stage I, 40.9% for Stage II and 67.6% for histological Grade I, 29.9% for Grade II.

Adult↗
PubMed1982

Rectal malignant lymphoma in chronic ulcerative colitis.

Carcinoma of the colon as a complication of ulcerative colitis is relatively common, whereas malignant lymphoma is apparently rare; there are approximately 20 recorded cases. We report a case of follicular lymphoma of the rectum in a 73 year old woman with a 21 year history of ulcerative colitis. In view of the possible immune basis of ulcerative colitis, it is important to report and accurately classify cases of lymphoma arising in association with it.

Aged↗
PubMed1981

Sulphasalazine retention enemas in ulcerative colitis: a double-blind trial.

Thirty-four patients with ulcerative colitis completed a double-blind assessment comparing the efficacy of two weeks of treatment with nightly retention enemas containing 3 g sulphasalazine or placebo. Symptom grading, sigmoidoscopic appearance, rectal biopsy specimens, and diary records were used to assess benefit and side effects. The active drug conferred significant benefit compared with placebo as shown by several criteria, but this benefit was confined to patients not already taking sulphasalazine by mouth. Overall assessment showed improvement in 11 of the 16 patients (70%) given the active treatment but in only two of the 18 (11%) given placebo. No side effects attributable to the drug were observed, even in patients previously intolerant to oral preparations. The logical therapeutic role of sulphasalazine enemas in ulcerative colitis would appear to be in patients who experience side effects such as nausea, abdominal discomfort, or headaches when taking the drug by mouth.

Clinical Trials as Topic↗
PubMed1981

Benign papillary mesothelioma of peritoneum: a histological, histochemical and ultrastructural study of six cases.

Six cases of localized benign papillary mesothelioma of peritoneum were retrieved from laboratory files over a 20-year period. One presented because of pain following torsion and the remaining five were incidental findings at operation. Light microscopy showed a delicate papillary stroma covered by a single layer of mesothelial cells. The mesothelial cells often showed punctate periodic acid-Schiff staining of cytoplasm. The brush border and stroma showed alcian blue positive staining which was abrogated by prior incubation with hyaluronidase. Electron microscopy revealed typical features of mesothelial cells with long microvilli, rough endoplasmic reticulum in relation to mitochondria, bundles of microfilaments, and tight junctions. Between cells there was a series of intercommunicating channels containing occasional lymphocytes and debris. These features are compared with nodular mesothelial hyperplasia, malignant mesothelioma and adenomatoid tumours of the genital tract. The necessity to distinguish benign papillary mesothelioma from metastatic carcinoma is stressed and relies on the recognition of their mesothelial origin.

Adult↗