PubMed Health⌕ Search

Biomedical subjects

J R HODGES

Publications and source records attributed to J R HODGES.

At least 19 recordsLinked to original sources
PubMed1959

The stability of endogenous corticotrophin in rat blood in vitro.

Endogenous corticotrophin is stable in blood in vitro for periods of up to 1 hr. at 4 degrees and 22 degrees , and in plasma for at least 24 hr. at -15 degrees . Estimates of plasma corticotrophin concentration provide less consistent results than assays done on whole blood. The optimal conditions for storing blood prior to the determination of its corticotrophin concentration are discussed.

Adrenocorticotropic Hormone↗
PubMed1958

A comparison of the pituitary inhibitory effects of prednisone, prednisolone, and hydrocortisone.

Prednisone, prednisolone and hydrocortisone, administered in doses of 1 mg. daily for thirty days, depressed the growth rate of rats. Prednisolone and hydrocortisone caused atrophy of the adrenal glands and increased the relative weights of the thyroid glands and testes. The apparently similar effects produced by prednisone were not significant. The seminal vesicles were not affected significantly by prolonged administration of prednisone, prednisolone or hydrocortisone. Pretreatment of rats with these steroids prevented the adrenal ascorbic acid depletion normally caused by laparotomy under ether anaesthesia. Prednisolone was slightly more potent and prednisone was considerably less potent than hydrocortisone in producing these effects.

Adrenal Glands↗