PubMed Health⌕ Search

Biomedical subjects

J R Haltom

Publications and source records attributed to J R Haltom.

7 recordsLinked to original sources

Functional endoscopic sinus surgery: results in the young child.

Recent studies have addressed the usefulness of functional endoscopic sinus surgery (FESS) in both adult and pediatric patients, but little information is available concerning the long-term followup of young children. During a 31 month period, 57 children, age six years or less had FESS performed by a single surgeon. In each case the child had failed aggressive medical management including long-term oral antibiotics. A coronal sinus CT scan was obtained prior to surgery and showed opacification of the maxillary and/or ethmoid sinuses with obstruction of the ostiomeatal complexes. A similar surgical approach was used in each case. There were no major surgical or anesthetic complications noted during the initial procedure or the followup debridement. To evaluate the results of FESS, a questionnaire was mailed to the parents of each patient. The questionnaires were completed 5 to 36 months after surgery (mean 17.3 months). Ninety-three percent of the children showed improvement based on the observations of their parents. Improvement was judged primarily by reduced symptoms, reduced need for antibiotics, and the need for fewer doctor visits during the followup period. In summary, FESS appears to offer a safe and effective technique to control sinus disease in children who do not respond to aggressive medical management. In skilled hands, this technique is associated with few complications and appears to offer relief even in young patients.

Child, Preschool↗

Functional endoscopic sinus surgery in children.

During the last decade, the usefulness of functional endoscopic sinus surgery (FESS) has been clearly demonstrated in adult patients. Several recent studies have described the use of FESS in children. Most of the patients in these earlier studies have been school age or older. This paper will examine the follow-up of 44 children treated using FESS. The children's ages ranged from 14 months to 13 years with a mean age of 54.5 months. Thirty-three of the children were less than 6 years of age with a mean age of 35.3 months. Follow-up after surgery varied from 1 to 21 months with a mean of 7.4 months. There were no major surgical or anesthetic complications noted during the initial procedure or at the follow-up debridement. Overall the children did well, with 86% showing improvement. It appears that FESS can be helpful for even young children with chronic sinusitis.

Adolescent↗

Evaluation of symptom relief, nasal airflow, nasal cytology, and acceptability of two formulations of flunisolide nasal spray in patients with perennial allergic rhinitis.

A new formulation of intranasal flunisolide containing less propylene glycol was compared with the original formulation for efficacy and acceptability in more than 200 patients with symptoms of perennial allergic rhinitis. In this multicenter, randomized, double-blind, parallel group study, symptomatic patients were treated with either the new or the original formulation of 0.025% solution of intranasal flunisolide for 4 weeks to provide 200 micrograms flunisolide daily. Both formulations were highly effective in decreasing symptom scores as evident from patient diary reports before and after treatment (P less than .001). Similarly, nasal airflow was improved with each treatment as measured by anterior rhinomanometry (P less than .0002) and the number of patients with nasal eosinophilia decreased (P less than .01). Finally, fewer patients using the new formulation reported nasal burning or stinging and the acceptability rating of the new formulation was higher.

Administration, Topical↗

The consistency of theophylline absorption from a sustained-release formulation in asthmatic children.

Theophylline absorption was studied in asthmatic children ages 2-7 years. A bead-filled capsule of sustained-release theophylline (Slo-Bid, William H. Rorer, Inc., Fort Washington, PA) was administered in equal doses twice daily (8 AM and 8 PM) to produce serum theophylline concentrations (STCs) between 10 and 20 micrograms ml. After 7 days, blood samples were obtained every 2 hours for 24 hours. This sequence was repeated after another seven days of treatment. Elimination values were calculated after an intravenous reference dose. Slo-Bid was completely absorbed (mean +/- SD percentage of dose absorbed of 117.1 +/- 26.1 on day 1, and 104.8 +/- 16.1% on day 2), and the pattern of absorption was consistent from day to day, with maximum STCs occurring 2-6 hours after the dose, and minimum STCs at or near the time of PM dose. The percentage of fluctuation of 149.7 +/- 49.7% and 163.0 +/- 114.0% (mean +/- SD) on days 1 and 2, respectively, was slightly higher than desired, but probably was a result of rapid theophylline clearance in this group of children (119.9 +/- 25.8 ml/hr/kg). Mean residence time for absorption after AM and PM doses indicated significantly longer time for absorption (ta) after the PM doses: mean +/- SEM ta for AM doses on days 1 and 2 was 2.8 +/- 0.3 and 2.7 +/- 0.2 hours, respectively, and increased to 3.9 +/- 0.3 and 3.7 +/- 0.5 hours after PM doses on days 1 and 2, respectively (p less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗

Pathogenesis of exercise-induced asthma: implications for treatment.

Although the clinical features of exercise-induced asthma (EIA) have been clearly described, the pathophysiology is incompletely understood. This review addresses some of the current concepts about the pathogenetic mechanisms of EIA and their implications for treatment of this problem.

Asthma↗

Theophylline absorption in young asthmatic children receiving sustained-release formulations.

Theophylline absorption from sustained-release formulations intended for administration every 8 hours and every 12 hours was examined in children ages 2 to 6 years during multiple dosing intervals. By generally applied measurements, including mean serum theophylline concentration, bioavailability over a single daytime dosing interval, and percent change in serum theophylline concentration over a single dosing interval, the preparations did not differ. However, over multiple dosing intervals, the 8-hour preparation varied in rate and extent of absorption, with subsequent large variations in serum theophylline concentrations. The 12-hour preparation, on the other hand, was completely bioavailable during each dosing interval, although the rate of absorption did differ from day to night, and was associated with generally acceptable changes in serum concentrations. Thus, analysis of dose-to-dose absorption was required to reveal the differences between the two study preparations. This indicates that traditional analysis of a single daytime dosing interval may be inadequate in the evaluation of preparations of sustained-release theophylline.

Asthma↗