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Biomedical subjects

J R Hayward

Publications and source records attributed to J R Hayward.

At least 19 recordsLinked to original sources
PubMed1995

Effects of physical activity on creatine phosphokinase and the isoenzyme creatine kinase-MB.

Creatine phosphokinase (CPK) and creatine kinase-MB (CK-MB) have been used extensively as diagnostic markers for myocardial infarction and skeletal muscle injury. Many factors affect the variability of serum CPK and serum CK-MB activity, especially physical activity. We discuss the influence of physical activity on muscle and serum CPK and CK-MB. The effect of acute and chronic exercise on CPK and CK-MB activity emphasizes the need to use measurements of serum CPK and CK-MB with caution when evaluating and diagnosing acute myocardial infarctions and skeletal muscle injury.

Adult↗
PubMed1990

Immunoaffinity purification and characterisation of p29--an estrogen receptor related protein.

p29, a 29 kDa protein recognised by D5, a monoclonal antibody prepared against partially purified cytosolic estrogen receptor (ER), has been purified to homogeneity from ZR-75-1, a human breast cancer cell line. Ammonium sulphate fractionation followed by immunoaffinity chromatography on a three column system using Protein A-Sepharose coupled D5, produced purified p29. Silver stained SDS one-dimensional polyacrylamide gel electrophoresis (PAGE) and two-dimensional PAGE showed p29 to have been purified to homogeneity. Amino acid analysis showed no unusual characteristics. Partial N-terminal sequencing studies showed that purified p29 shared a 100% homology with the sequence of a pp89, murine cytomegaloviral protein.

Amino Acid Sequence↗
PubMed1987

Evaluation of the regenerative capacity of the inferior alveolar nerve following surgical trauma.

The fate of 52 nerves where there was altered sensation following sagittal ramus osteotomy and mandibular advancement, and 15 nerves where this occurred after third molar removal were evaluated through questionnaires involving both subjective and objective components. The study covered an interval between six and 54.5 months, with a mean of 31.9 months. Of the altered nerves from sagittal ramus osteotomy, 53.8% returned to normal, while 60% returned to normal in the third molar group. No correlation was found between terms used by the patient to describe the altered sensation and prognosis of nerve regeneration. In addition, correlation was not noted between the topographic distribution of altered sensation and the prognosis or residual deficit. No significant difference was found between the two methods of assessing nerve regeneration. A relationship was noted between age of the patient and increasing incidence of persistent altered sensation.

Adult↗
PubMed1984

Major maxillomandibular malrelations and temporomandibular joint pain-dysfunction.

A retrospective questionnaire survey of 102 patients who underwent orthognathic surgery for maxillomandibular disharmonies assessed the incidence of TMJ pain-dysfunction in both pretreatment and posttreatment phases. While retrospective questionnaire studies have obvious limitations, the following conclusions deserve consideration. The incidence of TMJ pain-dysfunction symptoms found in this patient population appears to be higher than the incidence of those symptoms reported in previous epidemiologic studies of general populations which involved subjective symptoms alone. Maxillomandibular disharmonies may be an important etiologic factor in the development of TMJ pain-dysfunction. Surgical correction of the disharmony in a significant percent of patients with maxillomandibular disharmonies and concomitant TMJ pain-dysfunction may alleviate or improve the TMJ pain-dysfunction symptoms. There is a possibility that patients may develop TMJ pain-dysfunction symptoms after orthognathic surgery.

Female↗
PubMed1983

Management of the premaxilla in bilateral clefts.

Surgical management of the premaxilla in patients with bilateral clefting has been a controversial and perplexing problem. This paper discusses method and timing of treatment and proposes a philosophy of surgical management. By proper timing of repositioning procedures and bone grafting, more tissue can be salvaged and a more satisfactory functional result can be obtained.

Adolescent↗
PubMed1981

Advantages of long-acting local anesthesia using etidocaine hydrochloride.

A double-blind clinical evaluation comparing 1% etidocaine with 1/200,000 epinephrine and 2% lidocaine with 1/100,000 epinephrine for third molar surgery was done on 42 patients. Aspects of long-acting and short-acting local anesthesia were compared, including time of onset, potency, regression, duration, and appraisal by the patient. The preference of patients and the experience of postoperative pain are emphasized.

Acetanilides↗
PubMed1980

Cuspid gigantism.

Explore the source record for details and available documents.

Adolescent↗