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J R Jungck

Publications and source records attributed to J R Jungck.

8 recordsLinked to original sources
PubMed1982

Computer-assisted sequencing, interval graphs, and molecular evolution.

In 1945, Fox developed the strategy for sequencing long proteins by using overlapping fragments. We show how the formal mathematical technique for the construction of interval graphs (Gilmore and Hoffman, 1964) is useful both pedagogically for understanding the underlying logic of sequencing linear molecules and is more amenable to automation because of its algorithmic nature. We also present a computer program, that employs the interval graph algorithm, which can be used to sequence proteins when given digest data. An example is given to illustrate all the steps involved in the algorithmic processing of the data. The need for such developments with respect to molecular evolution is discussed.

Amino Acid Sequence↗
PubMed1978

The genetic code as a periodic table.

The contemporary genetic code is reflective of a significant correlation between the properties of amino acids and their anticodons in a periodic manner. Almost all properties of amino acids showed a greater correlation to anticondonic than to codonic dinucleoside monophosphate properties. The polarity and bulkiness of amino acid side chains can be used to predict the anticodon with considerable confidence. The results are most consistent with predictions of the "direct interaction" and "ambiguity reduction" hypotheses for the origin of the genetic code.

Amino Acids↗
PubMedDate not supplied

Circular countercurrent-distribution behavioral genetic maze.

An inexpensive, easily constructed apparatus for mass screening of taxes of small animals with a rapid and accurate assignment of individual behavior scores has been described that should be of utility in hastening a behavioral geneticist's chores and allow him to handle more populations with fewer mazes. Also, the apparatus is well suited for use within the constraints of the undergraduate laboratory.

Animals↗
PubMedDate not supplied

Group graph of the genetic code.

The genetic code doublets can be divided into two octets of completely degenerate and ambiguous coding dinucleotides. These two octets have the algebraic property of lying on continuously connected planes on the group graph (a tesseract) of the Cartesian product of two Klein 4-groups of nucleotide exchange operators. The K X K group can also be broken into four cosets, one of which has completely degenerate coding elements, and another that has completely ambiguous coding elements. The two octets of coding doublets have the further algebraic property that the product of their internal exchange operators naturally divide into two exactly equivalent sets. These properties of the genetic code are relevant to unraveling error-detecting and error-correcting (proof-reading) aspects of the genetic code and may be helpful in understanding the context-sensitive grammar of genetic language.

Genetic Code↗