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Biomedical subjects

J R Klos

Publications and source records attributed to J R Klos.

4 recordsLinked to original sources
PubMed1983

Immunoblastic lymphoma with extracellular and intravascular immunoglobulin deposits: immunocytochemical and electron microscopic studies.

Immunoblastic lymphoma (IBL) showing features of angioimmunoblastic lymphadenopathy (AIBL) is described. Abundant eosinophilic extracellular deposits were present in lymph nodes. Electron microscopic and immunoperoxidase studies showed this material was composed of degenerating tumor cells and polyclonal immunoglobulins (Mu and Alpha heavy chains and Kappa and Lambda light chains). Numerous arborizing vessels were thickened with monoclonal IgM(K) immunoglobulins. The tumor cell lysis and degeneration are though to be due to the high cell turnover and immune reaction to unrecognized substances.

Antibodies, Monoclonal↗
PubMed1980

Measles and appendicitis.

Two patients who were admitted in the prodromal stage of measles with right lower quadrant pain are described. One patient underwent appendectomy. Histologic examination of the appendix showed the characteristic Warthin-Finkeldey giant cells in the subepithelial layer and allowed the pathologist to predict a measles rash before it appeared. The second patient's pain resolved spontaneously and the measles rash appeared just prior to discharge from the hospital. A discussion of the association between measles and appendicitis is presented. It is concluded that although the association between measles and right lower quadrant abdominal pain is interesting, it must not dissuade the surgeon from performing an appendectomy if the patient's signs and symptoms suggest appendicitis.

Adolescent↗