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Biomedical subjects

J R McPherson

Publications and source records attributed to J R McPherson.

12 recordsLinked to original sources
PubMed2002

Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells.

Tumor necrosis factor-alpha (TNF-alpha) stimulates osteoblast production of interleukin-6 (IL-6), an inflammatory cytokine implicated in osteoclastic bone resorption. Therefore, we tested the hypothesis that TNF-alpha-induced IL-6 production in MG-63 osteosarcoma cells occurs via the p38 mitogen-activated protein kinase (MAPK) pathway. TNF-alpha activated p38 MAPK and stimulated IL-6 secretion by MG-63 cells, and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha-dependent IL-6 secretion. Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 MAPK activation by TNF-alpha enhanced IL-6 gene expression, and that the p38 MAPK-responsive region resided in the proximal 260-bp segment. Transfection of NFkappaB and C/EBPbeta-sensitive reporter promoter constructs demonstrated that NFkappaB activity was enhanced and that constitutive C/EBPbeta was inhibited by TNF-alpha, with both effects being p38 MAPK-dependent. In conclusion, although p38 MAPK activation by TNF-alpha stimulates IL-6 secretion by MG-63 cells, it has opposing effects on c/EBPbeta and NFkappaB activity.

Analysis of Variance↗
PubMed1984

Experience with providing research opportunities for medical students.

The purpose of the program described was to provide research training experience at the Mayo Medical School for third-year students. It was hoped the students would learn sound research principles, develop skills in evaluating research literature, and, while developing an area of expertise, enhance their self-image in relation to research. Faculty members were asked to participate as advisers/preceptors and to provide laboratory support for students. Surveys of the students' attitudes have shown very positive feelings concerning their research accomplishments and the value of the time they spent doing the research. Results in terms of numbers of papers written, published, and presented at meetings by the students indicate that the program is making a worthwhile contribution to the curriculum of the medical school.

Curriculum↗
PubMed1978

Stature change with aging in black americans.

The study consisted of a sample of 500 black Americans (50-104 years old) to determine whether or not there was a decrease in height among black Americans with increasing age. There is no significant difference between height and arm-span at the start of adult life. In order to study the loss of stature, as a result of senescence, a comparison of height with arm-span measurement was used. It was found that: (1) the black population has a greater decrease in height with aging than does the white population; (2) black males decrease approximately 4.2 cm in height every 20 years compared to 1.2 cm in the white population; (3) the older population sampled had shorter arm-spans as well as shorter stature.

Adult↗
PubMed1970

Jejunal biopsy.

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Abetalipoproteinemia↗