Mutant E. coli strain with temperature sensitive peptidyl-transfer RNA hydrolase.
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Amino Acids↗
Biomedical subjects
J R Menninger
Publications and source records attributed to J R Menninger.
A simple assay for protein chain termination using natural peptidyl-tRNA.
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Anti-Bacterial Agents↗
Amino acid accepting activity of deacylated peptidyl-tRNA.
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Carbon Isotopes↗
Peptidyl-tRNA hydrolase and protein chain termination.
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Carbon Isotopes↗
Attachment and detachment of bacteriophage lambda DNA in lysogenization and induction.
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Carbon Isotopes↗
Amber suppression and activating enzymes.
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Escherichia coli↗
Polypeptide chain termination using synthetic polynucleotides.
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Escherichia coli↗
Ribosome editing and the error catastrophe hypothesis of cellular aging.
Ribosome editing involves the dissociation during protein synthesis of inappropriate peptidyl-tRNA's, ones whose structure does not correctly complement the codon of the mRNA. This process is one of three stages in protein biosynthesis in which the frequency of errors in cellular proteins is controlled. These stages are reviewed and the implications of ribosome editing are described. A model for stability of the translation apparatus is criticized. Calculations using a revision of the model and experimentally reasonable values for the various parameters show varying time courses for error catastrophes.
Cell Survival↗