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Biomedical subjects

J R Patterson

Publications and source records attributed to J R Patterson.

8 recordsLinked to original sources
PubMed1992

Survey and risk assessment of radium contamination in a historic desk.

For many years the Physics Department of The University of Adelaide has owned a fine cedar desk which dates from before 1900. It was used by professors, including Sir Kerr Grant, for many years and probably Sir William Bragg. In April 1991, approximately 80 kBq of radium contamination was found in parts of the desk. Because of concern for the health of those who had used the desk, a thorough study was made of the nature and extent of the contamination and the risks to health from radon and from ingesting some of the radioactive material from contact with articles such as pencils, stamps and envelopes kept in the drawer. The risks have been shown to be small compared to other acceptable risks in modern society. The desk has been decontaminated and restored.

Australia↗
PubMed1978

Interstitial pneumonia from mitomycin.

Pulmonary disease has been associated with several chemotherapeutic agents but has not been reported in patients receiving the alkylating agent mitomycin (Mutamycin). We describe here the cases of three patients who developed interstitial pneumonia while receiving mitomycin therapy. Their clinical features including dyspnea, cough, and occasionally fever; reticular infiltrates were seen on chest roentgenogram. Histologically, diffuse alveolar septal edema, mononuclear-cell interstitial infiltrates, hypertrophy of alveolar lining cells, and alveolar septal collagen deposition were characteristic. Treatment with corticosteroids was associated with a rapid therapeutic response in all three patients.

Female↗
PubMed1976

Preferred surgical treatment for alveolar cell carcinoma.

An analysis of our experience with 48 patients having bronchiolar or alveolar cell carcinoma is reported. The remarkable biological variability of this peripheral tumor has important surgical implications. Basically, two dominant clinical presentations occur. In the less common diffuse or multinodular form, prolonged survival is infrequent regardless of the therapeutic approach. Often these patients die from respiratory compromise due to the tumor itself. In the more common localized or solitary form the prognosis for cure is good, approximating 47% or higher. Based on the material presented, lobectomy is the preferred method of surgical treatment. In patients manifesting multinodular disease, surgical resection rarely seems warranted. The concept of preserving pulmonary tissue is stressed.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1976

Exacerbation of porphyria during treatment of pulmonary tuberculosis.

Several attacks of acute intermittent porphyria complicated the treatment of a patient with pulmonary tuberculosis. To determine whether the attacks were drug-induced, the ability of a variety of antituberculous drugs to induce (delta)-amino-levulinic acid synthetase activity in a rat liver model was assessed. Pyrazinamide was found to be capable of significantly inducing amino-levulinic acid synthetase activity; the other antituberculous drugs caused either slight or no induction of amino-levulinic acid synthetase. The data suggest that pyrazinamide was capable of causing an exacerbation of the patient's porphyria. Tuberculosis, by causing debility, may also have aggravated this patient's previously latent porphyria.

5-Aminolevulinate Synthetase↗
PubMed1975

Lidocaine blood concentrations during fiberoptic bronchoscopy.

Blood lidocaine concentrations were measured in 21 patients during routine fiberoptic bronchoscopy. In one patient, concentrations were in the toxic range. Measureable, but generally safe, concentrations were observed in the remaining patients. Cardiac and central nervous system toxicity may result from lidocaine adsorption, particularly in the seriously ill patient, although none was observed during the course of these studies.

Absorption↗
PubMedDate not supplied

Determination of pentachlorophenol in animal tissues: a Canadian perspective.

Analytical methods for pentachlorophenol (PCP) residues in edible animal tissue have been reviewed, with particular reference to gas chromatographic methods of analysis. Results of analyses demonstrate that significant residues of PCP can persist for several weeks in animals exposed to contaminated bedding. National surveys in Canada have found that the incidence of PCP residues in pork in excess of 0.1 ppm was reduced from 32% of survey samples in 1981-1982 to 6.6% of samples tested in 1987-1988. An interlaboratory sample exchange among Canadian laboratories demonstrated that the PCP analytical method currently used by Agriculture Canada could be successfully transferred to other laboratories. An exchange of samples between regulatory laboratories of Agriculture Canada and the Food Safety and Inspection Service of the U.S. Department of Agriculture (USDA) demonstrated equivalency of results for the 2 methods currently used in the respective laboratories, with relative standard deviations for analytical results ranging from 4.4 to 22.2%.

Animals↗