Epidural analgesia and neonatal fever.
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Biomedical subjects
Publications and source records attributed to J R Pleasure.
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Forty-five arterial blood samples for oxygen saturation on 15 sick premature infants were significantly correlated with pulse oximeter determinations (r = 0.87, p less than 0.0001) giving a regression equation of y = 1.19X - 18.15. Chronologic age in the first 2 weeks of life did not alter the accuracy of the pulse oximeter. Four groups (in isolette with phototherapy off, in isolette with phototherapy on, on radiant warmer with phototherapy off, and on radiant warm with phototherapy on) were observed to see if environmental light and energy would affect pulse oximetry oxygen saturation values; no effect was observed. Therefore the pulse oximeter is an accurate machine to assess sick premature infant oxygen saturation. The measurements are not altered by environmental light.
An infant weighing 740 gm at birth underwent right internal jugular venous cannulation for the administration of parenteral nutrition at age 17 days. The roentgenogram obtained to assess catheter placement revealed a high right diaphragm for the first time in the course of the infant. The phrenic palsy was incurred during the cutdown in the neck of the tiny, then 650 gm, infant. Two similar patients are mentioned in the literature. The phrenic palsy appeared to delay improvement in the respiratory status of this infant. This patient illustrates the fact that phrenic nerve palsy is a potential complication of central line placement in the neck of a very low birthweight infant.
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The fourth smallest infant found to be reported with a long-term survival, a 440-g girl, was cared for in an intensive care nursery. With minimal intervention needed in this remarkable infant, her growth and development have shown an excellent outcome at the age of 2 years.
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A 27-year-old woman who was 34 weeks pregnant was admitted in a semicomatose state. Five days later she gave birth to an infant who demonstrated significant CNS depression. Elevated blood levels confirmed bromide intoxication in both the mother and infant secondary to chronic maternal bromide ingestion (Nervine). Simultaneous determinations revealed a higher initial serum bromide level in the infant compared to that of the mother in spite of a subsequent more rapid rate of disappearance in the neonate. It is suggested that the drug history obtained from the pregnant woman include nonprescription medications containing bromides. This possibility should also be included in the differential diagnosis in infants exhibiting evidence of CNS depression, particularly those born to mothers classified as neurotic or psychotic.
Temperatures for rewarming neonates have been established for convection incubators. The purpose of this study was to evaluate the effects on neonates when the skin surface was rewarmed at one of four different levels with an infra-red warmer. A total of 42 normal term neonates were first divided into four groups according to deep rectal temperature on admission; infants in each of the respective groups were then allotted to one of the following skin surface temperature set-point groups: 35, 36, 37 or 38 degrees c for rewarming under a servo-controlled infra-red heat source. Although rewarming at 38 degrees (100.4 degrees F) surfacetemperature bears the theoretic risk of the effects of hyperthermic stress to the neonate, particularly of apnea, the 12 infants rewarmed at this temperature set-point all achieved normal rectal temperatures significantly sooner than the infants in the other three groups without evidence of ill effects. The attainment of a rectal temperature of 37 degrees C within the 4 hr study period and the absence of hypoglycemia in the 38 degrees C skin temperature group was statistically significant when compared to the frequency of occurrence in the other groups.
An infant, 26 weeks gestation, had a stormy neonatal course; at 10 hours of age, initial cranial ultrasound apparently demonstrated a left subependymal hemorrhage placed somewhat medially with possible extension into the lateral ventricle. These ultrasound findings were present up to and including a study on the seventeenth day of life. At 7 months of age, repeat ultrasound once again demonstrated supposed hemorrhage which involved both choroid plexuses and the third ventricle or basilar cisterns. Computed tomography revealed a lipoma of the corpus callosum with calcifications. This patient is one of the youngest reported in the literature with this tumor.