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Biomedical subjects

J R Richardson

Publications and source records attributed to J R Richardson.

12 recordsLinked to original sources

Continuous infusion of intrathecal morphine to control acquired immunodeficiency syndrome-associated bladder pain.

A 36-year-old man with acquired immunodeficiency syndrome had incapacitating dysuria and vesical pain secondary to interstitial cystitis. When medical management and suprapubic urinary diversion failed to control the symptoms the patient was started on subarachnoid morphine sulfate. Bupivacaine was added 1 year later via an implanted Therex M-3000 implantable continuous infusion pump, which has continued successfully for more than 18 months. We believe that subarachnoid narcotics and other analgesic agents, such as clonidine, bupivacaine hydrochloride and baclofen, may prove equally valuable in the treatment of bladder spasm and pain. Furthermore, implanted intrathecal ports and pumps may have less associated risk of infection than the percutaneous vascular access catheters presently used for the continuous delivery of medications in immunosuppressed patients.

Acquired Immunodeficiency Syndrome

Angiographic management of retroperitoneal hemorrhage from renal angiomyolipoma in polycystic kidney disease.

Angiographic management of bilateral angiomyolipomas complicated by hemorrhage in autosomal dominant polycystic kidney disease is presented. The patient had mild stigmata of tuberous sclerosis, and a family history of tuberous sclerosis and autosomal dominant polycystic kidney disease. The radiographic features at diagnosis, and those present during and after embolization are described. Radiological criteria for diagnosis and successful control of bleeding with intra-arterial selective embolization are discussed. Radiographic features before, during and after embolization are exhibited.

Adult

Unsuspected intraperitoneal rupture of bladder presenting with abdominal free air.

We present a case of intraperitoneal rupture of the bladder discovered during exploratory laparotomy for abdominal free air associated with an indwelling Foley catheter found in the peritoneal cavity. This report emphasizes the need for systematic and thorough evaluation of the genitourinary tract in the patient with multiple trauma.

Aged

Herpes simplex neuropathy.

Atypical facial pain and permanent sensory loss in the second and third divisions of the trigeminal nerve developed in a patient who had had multiple attacks of herpes simplex neuralgia over a period of 8 years. Intravenous cytosine arabinoside failed to prevent a recurrence of the vasicular eruption, but carbamazepine produced symtomatic pain relief. This case demonstrates that herpes simplex can closely mimic herpes zoster as a cause of postherpetic neuralgia and suggests a possible etiology of atypical facial pain and/or trigeminal sensory neuropaty in some patients.

Adult

Distribution and removal of cadmium from milk.

Distribution of added cadmium in milk systems and the feasibility of removing cadmium were investigated. In milk containing 1 ppm cadmium, 96% of the added cadmium chloride was dispersed in the skim milk fraction, and 3% was associated with the cream fraction. Cadmium was not bound strongly to any protein fraction. The association of cadmium with acid casein, whey proteins, and the fat globule membrane was 18,6, and .5% of total added cadmium. With a 5-min exposure thiosuccinylated amino-ethyl cellulose, thionitrocarboxyphenylated aminoethyl cellulose, and reduced human hair removed 72, 70, and 30%, respectively, of added cadmium in skim milk previously equilibrated for 2 h at 37 C. Increasing equilibration time beyond 24 h had no effect on removal efficiency whereas increasing pH decreased cadmium removal markedly.

Animals

Locomotory adaptations in a free-lying brachiopod.

Magadina cumingi inhabits an environment of high current energy and mobile sediments by using its pedicle in Pogo-stick fashion as an elevating device. This type of progression is associated with pedicle musculature different from that of attached and other free-lying forms, and some diagnostic differences in muscle attachment areas are evident in preservable hard parts.

Animals

Adenocarcinoma of kidney in a child. Tumor rupture following trauma.

A ten-year-old white girl with Stage I clear cell adenocarcinoma of the kidney was seen after local trauma had produced a renal laceration with rupture of the tumor. She was treated with nephrectomy followed by a second exploration several months later. No adjunctive therapy was used.

Adenocarcinoma

Non-operative treatment of the ruptured bladder.

Open surgical drainage is not necessary in all patients with bladder rupture. Two patients with an extraperitoneal rupture and 1 with an intraperitoneal rupture were successfully managed with urethral catheter drainage only. Our rationale and specific criteria for this treatment are presented. We believe that in selected patients urethral catheter drainage is a safe, simple and effective method of treating the ruptured bladder.

Adult