Biomedical subjects
J R Robinson
Publications and source records attributed to J R Robinson.
Corneal absorption of fluorometholone in rabbits. A comparative evaluation of corneal drug transport characteristics in anesthetized and unanesthetized rabbits.
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Drop size and initial dosing frequency problems of topically applied ophthalmic drugs.
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Ocular evaluation of methylcellulose vehicle in albino rabbits.
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Corneal permeation of topical pilocarpine nitrate in the rabbit.
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The livestock processing industry and the veterinarian.
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Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism.
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Further studies on genetically mediated differences in monooxygenase activities and spin state of cytochrome P450 iron from rabbit, rat, and mouse liver.
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Glycine metabolism. Lipoic acid as the prosthetic group in the electron transfer protein P2 from Peptococcus glycinophilus.
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Lacrimal and instilled fluid dynamics in rabbit eyes.
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Altered bioavailability of drugs in the eye due to drug-protein interaction.
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Competitive inhibition of drug-protein interaction in eye fluids and tissues.
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Bell's palsy. A predisposition of pregnant women.
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Phosphotransacetylase from Clostridium acidiurici.
The phosphotransacetylase from Clostridium acidiurici has two properties not observed for this enzyme in other bacteria: (i) it requires a divalent metal for activity, and (ii) it is not subject to uncoupling by arsenate. The enzyme has been obtained in highly purified form, with a specific activity 500-fold higher than crude extracts. Ferrous or manganous ions are required for maximal activity, with Mn(2+) being 50 to 75% as effective as Fe(2+). The acetyl group can be transferred from acetyl phosphate to coenzyme A in 20 mm arsenate without a net decrease in high-energy acyl linkages. Likewise, H(32)PO(4) (2-) will exchange with acetyl-PO(4) (2-) in the presence of arsenate without loss of acetyl phosphate. This suggests that the active site on the enzyme is capable of discriminating between phosphate and arsenate while permitting the reversible transfer of acyl groups between CoA and phosphate.
Why mentally subnormal patients fail in outside employment.
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Linear free energy models for ester solvolysis with a critical examination of the alcohol and phenol dissociation model.
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Relative substituent effects on alkaline solvolysis of -lactams (2-azetidinones) and amides.
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Control of water content of non-metabolizing kidney slices by sodium chloride and polyethylene glycol (PEG 6000).
1. Cortical slices from kidneys of adult rats were equilibrated for 24 and 48 hr in the refrigerator in solutions containing 5 mM-K, 2.5 mM-Ca and Mg, M/15 phosphate buffer (pH 7.4), 5 mM cyanide and iodoacetate with 5, 6, 7 and 8% polyethylene glycol (PEG 6000) and 77, 154, 308, 462 and 770 mM-NaCl.2. There were no consistent differences in water content between slices after 24 and after 48 hr.3. Slices contained more water when either the concentration of NaCl or that of PEG was reduced. The increase in water content induced by lowering the concentration of either was prevented by a higher concentration of the other.4. Water content was held constant at 3.25 kg.kg(-1) dry PEG-free tissue despite a fall in [NaCl] from 770 to 77 mM (more than 1200 m-osmole.kg(-1)) by increasing PEG from 5.1 to 7.7% corresponding to an increase of the order of 15 m-osmole.kg(-1).5. It is suggested that PEG 6000 was so much more effective than NaCl, osmole for osmole, because PEG 6000 acted as a non-penetrating solute, whereas NaCl penetrated the slices and reduced the ;Donnan excess' component of the intracellular colloid osmotic pressure so that this could be balanced by a smaller concentration of PEG.