Biomedical subjects

J R Royce

Publications and source records attributed to J R Royce.

14 recordsLinked to original sources

PubMed1977

Effects of septal lesions on factors of mouse emotionality.

Sixty mice from two emotionally divergent inbred strains, BALB/Alb and C57BL/10Alb, were assigned to one of three experimental groups: septal surgery, control surgery, and intact. Subsequently, all animals were administered a battery of five tasks that yielded 19 measures of emotionality. Factor scores were computed on six invariant factors obtained previously from these measures. Each factor was analyzed by an analysis of variance design with main effects for strain, sex, lesion, and days of testing. Strain and lesion main effects were found on Motor Discharge and Autonomic Balance, Strain X Lesion interaction effects on Motor Discharge and Tunneling 1, and a Lesion X Sex interaction effect on Territorial Marking. The results support the interpretation that the septum affects distinct processes modulating Autonomic Balance and Motor Discharge factors.

Animals↗

PubMed1975

Behavior genetic analysis of mouse emotionality. III. The diallel analysis.

A total of 775 pure-strain and F1 mice were obtained from a 6 X 6 diallel mating plan. Previous factor analysis of 42 measures of emotionality identified 14 behavioral factors, ten of which were interpretable. Hayman's analysis of variance and analysis of diallel crosses were applied to each of the factors. In general, the findings indicate that the mode of inheritance for emotionality factors is polygenic and in the direction of complete dominance. However, a major point of this investigation is that the mode of inheritance of highly complex behavior such as emotionality depends on the factor in question. For example, the breakdown of dominance effects by factor was as follows: partial dominance--Motor Discharge, Food Motivation, Tunneling-2, and Activity Level (males); complete dominance--Audiogenic Reactivity, Underwater Swimming (males), and Activity Level (females); overdominance--Acrophobia, Territorial Marking (males). Additional findings include directional dominance for Underwater Swimming and Audiogenic Reactivity, and significant sex differences for eight of the 14 factors.

Animals↗

PubMed1975