Biomedical subjects

J R Seehafer

Publications and source records attributed to J R Seehafer.

7 recordsLinked to original sources

PubMed1982

Treatment of cicatricial (benign mucous membrane) pemphigoid with dapsone.

Treatment of cicatricial pemphigoid is a problem because patients afflicted are elderly, the disease is chronic, systemic agents required for control are potentially toxic (particularly to older patients), and the disease is often in an advanced stage when the diagnosis is established and requires aggressive therapy for control. We selected dapsone as an alternative anti-inflammatory agent because it has provided control in a subset of patients with bullous pemphigoid, five of six who had oral lesions. Twenty-four patients with cicatricial pemphigoid were treated with dapsone. Twenty (83.3%) had partial or complete control with mild to no inflammatory activity. Control was obtained within 4 weeks in eleven of the twenty patients. The use of dapsone was discontinued in two patients because it failed to control their disease and in four patients (two with control) because of drug-related side effects. Cicatricial pemphigoid may be added to the list of dapsone-responsive dermatoses.

Adult↗

PubMed1981

Lichen planus-like lesions caused by penicillamine in primary biliary cirrhosis.

Six patients with primary biliary cirrhosis experienced lichen planus-like lesions while taking penicillamine. Oral lesions developed in all patients, and the lichenoid lesions also appeared elsewhere in two patients. Lichen planus-like lesions developed from four to 16 months after penicillamine therapy had been started, and, in four cases, they resolved in one to three months after use of the drug was stopped. Two patients have continued using penicillamine despite adverse cutaneous and mucosal reactions and have continued to experience lichen planus-like lesions intermittently. Other cutaneous reactions associated with penicillamine are reviewed.

Clinical Trials as Topic↗

PubMed1980

Cutaneous manifestations of angioimmunoblastic lymphadenopathy.

Six of 22 patients with angioimmunoblastic lymphadenopathy seen at the Mayo Clinic from 1962 to 1978 had associated cutaneous lesions exhibiting characteristic histologic features at biopsy. Clinically, three patients had generalized maculopapular eruptions, two had generalized petechiae, and one had generalized erythroderma and petechiae located on the extremities. In each patient, the eruption occurred concurrent with or prior to the onset of generalized lymphadenopathy. Pathologically, all skin biopsy specimens showed lymphohistiocytic vasculitis, vascular proliferation, extravasated RBCs, and occasional scattered mature plasma cells. These histologic findings were similar to but less intensive than those noted on biopsy specimens of involved lymph nodes. Although suggestive of angioimmunoblastic lymphadenopathy, the histologic findings of skin lesions do not appear to be diagnostic, thus stressing the difficulty of defining the syndrome in the absence of lymph node biopsy.

Aged↗

PubMed1979

Epithelioma cuniculatum: verrucous carcinoma of the foot.

A patient with epithelioma cuniculatum, an unusual, highly keratinizing squamous cell neoplasm of the foot with locally aggressive behavior, is presented herein. Review of the literature reveals several similar cases that are reported under the names of epithelioma cuniculatum, papillomatosis cutis carcinoides, and verrucous carcinoma of the skin. The relationship of this neoplasm to other forms of verrucous carcinoma is noted. Lack of metastatic involvement indicates that a conservative surgical approach should be used, when possible, in the therapeutic management of this lesion.

Carcinoma, Papillary↗

PubMed1979

Bowel bypass syndrome.

We report two cases of a syndrome related to the bowel bypass surgical procedure. This syndrome consists of a flu-like illness, with temperatures from 38.3 to 39.4 degrees C (101 to 103 degrees F), chills, malaise, and inflammatory papules and pustules, 2 to 4 mm in diameter, on the extremities and upper part of the trunk. The illness lasts two to six days, and then recurs in one to six weeks. During some episodes, myalgia and polyarthralgia occur; between episodes, joints are normal. In both patients, extensive evaluations had been made to determine the cause of the persistent illness before this distinctive syndrome, related to the bowel bypass surgical procedure, was recognized. These two cases are also illustrative of the two therapeutic approaches that may be of value: administration of antibiotics, esecially metronidazole, or reconstitution of the normal bowel anatomy. The relationship of this syndrome to the arthritis associated with bowel bypass and to bypass enteropathy is discussed.

Female↗

PubMed1979

Bilateral verrucous carcinoma of the feet.

A 51-year-old woman had had bilateral verrucous carcinoma of the feet for ten years. The tumors had been treated many times as extensive verruca vulgaris before a biopsy was performed and the true neoplastic nature of the lesion recognized. This case illustrates the necessity of performing biopsies on atypical or frequently unresponsive verrucous tumors.

Biopsy↗

PubMed1976

Bilateral scalp necrosis in temporal arteritis. A rare complication of Horton's disease.

In an elderly man bilateral temporal scalp necrosis complicating temporal (systemic giant cell) arteritis developed. The patient also demonstrated other features characteristic of this entity: (1) exquisite scalp tenderness and headache, (2) onset late in life, (3) visual disturbances, (4) general debility, (5) diagnostic temporal artery biopsy, and (6) gradual healing with glucocorticosteroid therapy. A computer assisted review revealed 13 similar cases of scalp necrosis associated with temporal arteritis published in the English literature.

Aged↗