Seasonal variations in the cyanide content of Poa aquatica.
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Animals↗
Biomedical subjects
J R Sharman
Publications and source records attributed to J R Sharman.
OV-225 as a stationary phase for the determination of anticonvulsants, mexiletine, barbiturates, and acetaminophen.
Rapid methods of analysis for anticonvulsants (phenobarbitone, carbamazepine, primidone and phenytoin simultaneously and ethosuximide), barbiturates, mexiletine, lidocaine and acetaminophen are described. All drugs are chromatographed on OV-225 at various temperatures and detected using a nitrogen specific detector. OV-225 has proved to be superior to the more common SE-30, OV-17 and OV-1 phases, particularly for the simultaneous determination of the four anticonvulsants. No problems relating to the bleed of cyanopropyl containing stationary phase into the nitrogen specific detector have been encountered.
Acetaminophen↗
A simple method for determining thiopental in plasma.
A simple rapid HPLC method for the measurement of thiopental is described. Plasma was deproteinised with 50% (v/v) acetonitrile in methanol containing flufenamic acid as an internal standard. Chromatography was carried out on a C-18 mu Bondapak reverse phase column using 220 mL of buffer (1.79 g of ammonium dihydrogen phosphate and 1.75 g of sodium sulfate adjusted to pH 7.9 with ammonium hydroxide) in 300 mL of methanol. Detection at 280 nm was near the absorption maxima of both thiopental and flufenamic acid. The method is linear up to 75 micrograms/mL and is therefore suitable for the measurement of thiopental in plasma from patients sedated by thiopental infusion. The sensitivity can be increased such that single dose studies can be investigated.
Chromatography, High Pressure Liquid↗
Tinidazole pharmacokinetics in severe renal failure.
The single-dose pharmacokinetics of intravenously and orally administered tinidazole were studied in normal subjects and patients with severe chronic renal failure. The clearance of tinidazole was also measured in patients on regular haemodialysis. After intravenous administration the mean elimination half-life of tinidazole was 17.1 +/- 2.3 (SD) hours in the normal subjects and 16.9 +/- 4.9 hours in patients with renal failure; the mean apparent volumes of distribution were 0.80 +/- 0.09 L/kg and 0.69 +/- 0.09 L/kg, respectively. Following oral administration the mean elimination half-life was 15.6 +/- 1.6 hours in the normal subjects and 18.4 +/- 3.5 hours in patients with renal failure; there were no statistically significant differences in these pharmacokinetic parameters. There was no accumulation of the major metabolite (hydroxymethyl tinidazole) in normal subjects or in patients with renal failure. Tinidazole clearance during haemodialysis was 71 +/- 7.7 ml/min. In the presence of renal failure no modification of tinidazole dosage would appear to be necessary. Tinidazole should be administered in full dosage following haemodialysis.
Administration, Oral↗
Doxepin plasma concentrations in clinical practice. Could there be a pharmacokinetic explanation for low concentrations?
During therapeutic use of doxepin, we have often observed unexpectedly low doxepin plasma concentrations in patients on moderate dosages, e.g. 100 to 200mg daily. While non-compliance seemed the most likely explanation, we present the data for 6 patients in whom we considered non-compliance unlikely. The data can be explained by hypothesizing that in some patients, there is not a linear dosage-plasma concentration relationship and that on a steady dosage, plasma concentrations are not always maintained. If these phenomena can be more carefully documented they may assume clinical importance; indeed for 2 of the patients studied the falling plasma concentrations on a steady dosage were associated with a recurrence of depression.
Depressive Disorder↗