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Biomedical subjects

J R Srigley

Publications and source records attributed to J R Srigley.

61 records · Page 4Linked to original sources
PubMed1984

Solitary intestinal fibromatosis with perinatal bowel obstruction.

Three newborn male infants presented with bowel obstruction in the first day of life and at surgery were found to have solitary tumors involving the small or large intestine. Histologic examination in each case showed a transmural infiltrative spindle cell lesion having the morphologic features of fibromatosis. Ultrastructural studies in one case revealed the tumor to be composed of myofibroblasts. The patients are all alive and well without recurrences 26 months to 10 years after surgery. Only 3 previous cases of solitary congenital fibromatosis of the intestinal tract have been reported. Some of the other congenital spindle cell tumors cited in the literature under various names have morphologic and biologic similarities to our cases and may in fact be examples of congenital fibromatosis. The appropriate treatment of this unusual lesion is local excision, and the prognosis is excellent.

Colonic Neoplasms↗
PubMed1983

Hyponatremia secondary to olfactory neuroblastoma.

A patient with a four-year history of unexplained hyponatremia was seen with recurrent nasal discharge and was found to have a typical olfactory neuroblastoma. The clinical laboratory diagnostic studies suggested that the patient's sodium deficiency was secondary to the syndrome of inappropriate antidiuretic hormone. Subsequent resection of the neoplasm led to resolution of the hyponatremia, suggesting that a (tumor-associated) humoral factor, such as vasopressin or a vasopressinlike substance, was responsible for the electrolyte disturbance. A search of the literature disclosed one previous case of vasopressin-secreting nasal neuroblastoma.

Adult↗
PubMedDate not supplied

Selected ultrastructural aspects of urothelial and prostatic tumors.

Ultrastructural techniques have been widely applied in the study of urothelial and prostatic tumors. In the common proliferative diseases affecting the lower urogenital tract, electron microscopy has provided us with a greater understanding of the pathobiology and morphology of these disease processes. Specific diagnostic application, however, has been limited. In the unusual tumors affecting urothelium and prostate such as neuroendocrine carcinoma, carcinosarcoma, and sarcomas, electron microscopy has provided some practical diagnostic information of value in patient management. This paper provides a survey of the fundamental and practical contributions of ultrastructural studies in the prostatic and urothelial areas.

Adenocarcinoma↗
PubMedDate not supplied

The ultrastructure and histogenesis of male germ neoplasia with emphasis on seminoma with early carcinomatous features.

The range of ultrastructural morphology was studied in 107 male germ cell neoplasm to assess relationships among tumor subtypes and to consolidate diagnostic criteria. Eighty-three pure-pattern neoplasms including 47 seminomas, 26 embryonal carcinomas, 10 endodermal sinus tumors, and 24 mixed germ cell tumors were analyzed. In the seminoma category, 4 cases showing cell surface specialization in keeping with early carcinomatous transformation were noted. The finding suggested a closer link between seminoma and nonseminomatous germ cell tumors than had been traditionally recognized and was in keeping with other clinical, histologic, biochemical, and xenograft observations. Subtypes of nonseminomatous germ cell tumors also exhibited a continuum of ultrastructural morphology with some types such as embryonal carcinoma and endodermal sinus tumor often blending together. At a practical level, electron microscopy has been of value in selected differential diagnoses such as seminoma versus lymphoma.

Choriocarcinoma↗