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J R Susini

Publications and source records attributed to J R Susini.

6 recordsLinked to original sources
PubMed1991

[Antidepressive treatments. Predictive factors of tolerability].

Conducting an antidepressant treatment supposes the analysis of various parameters concerning patients, depressive illness and psychotropic drugs. The first determinant of prescription is the expected antidepressant effect. But regarding the role of compliance in the efficacy of treatment, probable tolerability also plays a role. It remains difficult to predict tolerability. A questionnaire was designed to assess the relevance of various predictive factors taken into account in the prognosis of tolerability: global tolerability, patient's psychopathological structure, clinical aspects of depression and characteristics of the particular antidepressant being used.

Antidepressive Agents↗
PubMed1982

[3H-Imipramine binding to human platelets. A peripheral index in depressive syndromes (author's transl)].

3H-imipramine shows specific, high-affinity binding to human platelet sites. The characteristics of these specific binding sites are very similar to those previously described in the rat brain. The inhibitory effects of 11 tricyclic antidepressants on 3H-imipramine binding to human platelets were investigated. There was a significant correlation between the inhibition observed and the average therapeutic doses of antidepressants, which suggests that the binding sites may be involved in the mode of action of these drugs. The number of binding sites (Bmax) for 3H-imipramine was compared in 39 controls and in 37 hospital patients with untreated severe depressive syndrome and was found to be significantly smaller in depressed patients, without any modification of the affinity constant Kd. The significance of these findings and their changes under treatment are discussed.

Adult↗
PubMedDate not supplied

[Cerebral x-ray computed tomography in anorexia nervosa. Study of 16 cases].

Cranial computerized tomography scan was used to study 16 cases of anorexia nervosa. The effect of treatment was explored by a second computerized tomography scan in 9 of the cases. Enlargement of cortical sulci and/or ventricular dilatation were demonstrated in 14 patients (87.5%). It was shown that the amelioration of body weight was related to the reversibility of computerized tomography scan abnormalities in 8 cases (89%). The authors discuss different aetiological hypotheses explaining these findings. They attempt to clear out the importance of the cranial computerized tomography in this disorder.

Anorexia Nervosa↗