Biomedical subjects
Publications and source records attributed to J R Vilanova.
We report a case of right intrathoracic kidney associated with a complex somite malformation that comprised vertebral fusion and right intrathoracic supernumerary ribs. The interpretation of this association as a disease model of nature allows us to propose a unifying hypothesis on the pathogenesis of this form of renal dystopia.
The microscopic anatomy of the oesophago-gastric territory is interpreted as the result of the interaction of three main phenotypes: squamous, oxyntic and intestinal. This synthesis allows the comparison between phenotype development, atrophy and metaplasia. The concomitances in the processes of development and repair lead to the proposal of an intestinalization gradient inherent to the oesophago-gastric field. This hypothesis permits an integration of the epithelial changes associated with gastritis and oesophagitis together with ontogenesis. The global tendencies in epithelial development and repair are discussed; a link between the two appears evident. The shifting potential of the progenitor gland zones in development and repair is in consonance with Wolpert's theory of positional information.
The specialized conducting systems of 44 hearts with posterior-inferior acute myocardial infarction were studied to clarify the anatomic basis of atrioventricular (AV) block. The results showed a lack of correlation between the block and the lesional pathology of the specialized conducting system. On the other hand, an evaluation of the atrial prenodal myocardium revealed strong clinicopathologic correlation between the block and the necrotic damage to these fibers. Twenty-nine or 97% of patients with AV block showed acute necrosis of the prenodal atrial myocardium. Considering the conducting prenodal septal atrial myocardium as a suprahisian structure, the necrosis at this level would provide an anatomic basis of the block in posterior-inferior acute myocardial infarction. Analysis of the behavior of the AV block after pharmacologic treatment further established a relationship between the block and acute lesions in the central conduction system.
A case of Langerhans' cell granulomatosis associated with gastric adenocarcinoma is reported. A review of the literature demonstrate an association of this entity with Hodgkin or non-Hodgkin lymphomas alone. The discussion is centred on differential diagnosis from the pseudo-sarcoid granulomatous reaction. Further reports may assist in classifying the granulomatous reaction to tumours into two types, epithelioid and Langerhans.
Pattern formation in chondroid development is compared with growth models exhibited by mesenchymal and myxoid chondrosarcomas. The results reveal strong similarities between mesenchymal chondrosarcoma and normal chondrogenesis. The fine vascularization of the tumor lobules of myxoid chondrosarcoma is discussed in relation to chondroid differentiation. A common histogenetic approach to the interpretation and classification of these neoplasias is proposed.
A previously unrecognized association of pulmonary rhabdomyomatous dysplasia and congenital posterolateral diaphragmatic hernia is reported. The authors subscribe to the concept of ectopia and postulate an anomalous migration of cervical "diaphragmatic" rhabdomyoblasts as the most probable origin of the pulmonary muscle fibers.
Biopsy material from 42 cases of florid hyperplastic cystic disease of the breast were reviewed and were found to have foci of apocrine metaplasia. This appearance was limited to the ductular epithelium of hyperplastic lobules. It is believed that this scattered change is an initial feature in relation to the genesis of apocrine-lined and fully developed cysts.
The vascular architecture of the developing Sprague-Dawley rat spinal cord from E11 through E16 is reported. The paraffin-embedded cord is serially sectioned in the sagittal, transversal and frontal planes and stained with PAS and methenamine silver. Serial semithin transverse sections are stained with toluidine blue. The results demonstrate two highly integrated vascular systems: one sagittally disposed in three concentric networks and the other radially oriented around the cord. The sagittal plexus is configurated by rhombohexagonal polygons. The lateral radial stem vessels anastomose with the sagittal systems at the polygonal vertex. A structural vascular model of the cord is proposed. The periodical sequence distribution of vessels in the three planes and their relationship to spinal ganglia is suggestive of a neural metamera vascularly determined.
A conventional histopathological and quantitative morphometric study of 28 capsulated peripheral and spinal nerve benign schwannomas demonstrated linear and parabolic correlation between Antoni B tissue, vascularity and tumour size. The results support the endoneural connective tissue origin of Antoni B, and suggest a model of tumor growth that is partially limited by the growth potential of the Antoni B and/or the vascular component.
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A case of retroperitoneal inflammatory fibrous histiocytoma associated to a marked granulocytic blood reaction and high eosinophilic count is reported. The paraneoplastic nature of the haematological findings and their probable prognostic role are discussed. Ultrastructurally the tumor does not differ significantly from "non inflammatory" fibroxanthosarcomas.
The study concerns a problem of practical importance in the daily routine work. 218 cases of focal fibrous disease of the breast were classified into three types with conventional methods of pathohistology and statistics. The peak incidence between 20 and 25 years is considerably lower than the incidence figures reported by other authors. The authors postulate the progressive evolutive nature of the lesion.
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Explore the source record for details and available documents.