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J R Yuste

Publications and source records attributed to J R Yuste.

12 recordsLinked to original sources
PubMed2006

[The most common infections in the transplanted patient].

Organ transplantation has become one of the most important areas of medical research and, at present, is still the only therapeutical tool for several diseases. However, there are a number of factors related to transplantation, like immunosuppression and prolonged neutropenia that affect the incidence of infection. These infections are somehow peculiar to transplant recipients. In fact, there are infectious diseases that only occur in immunodepression situations and, moreover, clinical expression of these infectious diseases can be quite different from that in immunocompetent patients. Besides these aspects, some infections, due to the high prevalence described, must be considered for prevention strategies because they continue to be a principal cause of morbidity and mortality, either due to direct effects or to their implication in the pathogenesis of rejection. These strategies commence before transplantation by active immunization through vaccine administration to the patient and to people in the milieu and continue after transplantation with prophylaxis or pre-emptive therapy. The importance of infectious diseases in the evolution and prognosis of transplant recipients gives a special meaning to the understanding of associated infections, their clinical expression and ways of prevention and treatment.

Heart Transplantation↗
PubMed1997

[Prevalence of hypercoagulation conditions in patients with thrombosis in Northern Navarra].

BACKGROUND: To determine the prevalence of hypercoagulability states in patients with thromboembolic disease in Septentrional Navarra. PATIENTS AND METHODS: 74 patients were studied (13 female, mean age [+/- SD] 43.5 +/- 13.9 years, range 22-81) with: deep venous thrombosis (DVT) with or without pulmonary embolism (PE) in 15 patients; ischemic stroke (IS) in 20 patients and; myocardial infarction (MI) in 39 patients. Antithrombin III, C protein (CP), plasminogen, plasminogen activator inhibitor (PAI), total S protein (TSP), free S protein (FSP), lupus anticoagulant (LA) and anticardiolipin antibodies (ACA) type IgG were determined in all patients. RESULTS: The prevalence of hypercoagulability state was 27% in patients with thromboembolic disease; 26.6% in patients with PE (20% with ACA and 6.6% with CP deficiency); 30% in patients with IS (15% with ACA, CP deficiency in 5%, FSP deficiency in 5%, and PAI raising in 10%) and in the 25.6% of patients with MI (15.3% with ACA, 2.5% with CP deficiency, 2.5% with TSP and FSP deficiency and PAI raising in the 7.6%). CONCLUSIONS: In Septentrional Navarra population with thromboembolic disease the presence of hypercoagulable states is high. In our study, the most common hypercoagulable state was the presence of ACA, followed by PAI raising and by the CP deficiency.

Adult↗
PubMed1996

Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid syndrome.

Antiphospholipid antibodies are a type of autoantibodies that have been implicated in the occurrence of thrombocytopenia and thrombotic events and have been described in autoimmune disorders and diverse viral diseases. In this study anticardiolipin antibodies (immunoglobulin G [IgG] isotype) were determined in serum from 100 patients with chronic hepatitis C and 52 healthy controls. In addition, hepatitis C virus (HCV) markers (anti-HCV and HCV RNA) were investigated in 73 patients with thrombotic disorders and no clinical evidence of liver disease; of these patients 37 cases tested negatively for anticardiolipin antibodies and 36 positively. Anticardiolipin test was positive more frequently (22%) in the group of patients with chronic hepatitis C than in healthy controls (1.9%; P < .001). Using conditional logistic-regression analysis we found that in hepatitis C patients the presence of thrombocytopenia, portal hypertension and the existence of prior thrombotic episodes were significantly related to positivity for anticardiolipin antibodies (P < .05 in all cases). In patients with no evidence of liver disease and a history of thrombotic events, hepatitis C markers were absent in all cases who tested negatively for anticardiolipin antibodies (n = 37), but were present in 16.7% of those positive for anticardiolipin (n = 36) (P = .01). In conclusion, anticardiolipin antibodies are frequently found in patients with chronic hepatitis C and in these patients they may be implicated in the occurrence of thrombosis and in the development of thrombocytopenia. Occult HCV infection is present in a significant proportion of patients with thrombotic disorders and positive for anticardiolipin (the antiphospholipid syndrome).

Adult↗
PubMed1996

[The POEMS syndrome, apropos of 2 cases and review of the literature].

We describe two cases of POEMS syndrome, both with polyneuropathy, monoclonal gammopathy of the IgG lambda type, thickening of the skin with Raynaud phenomenon, multiple osteosclerotic lesions and hypothyroidism. One of them, also had papilledema, elevated cerebrospinal fluid protein, intracranial hypertension and phrenic nerve palsy; the other one had ascites and hepatosplenomegaly. Phrenic nerve palsy associated to this syndrome has not been described previously.

Ascites↗
PubMedDate not supplied

[Antiphospholipid syndrome].

Antiphospholipid syndrome is a well-defined clinical and serological entity characterized by arterial and/or venous thrombosis, recurrent abortion and thrombocytopenia. Anticardiolipin antibodies and lupus anticoagulant are autoantibodies directed against negatively charged phospholipids, which represent the serologic criteria for the diagnosis of the antiphospholipid syndrome. In this review the pathogenic mechanisms of anticardiolipin antibodies, their clinical findings and the current therapeutical strategies are discussed.

Abortion, Habitual↗
PubMedDate not supplied

[McArdle's disease. Apropos of a case].

McArdle's disease (glycogenosis type V) is a metabolic disorder of hydrocarbons, inherited with autosomic recessive pattern. Biochemically is defined by a myophosphorylase deficiency; clinically it is characterized by exercise intolerance, due to the impossibility of providing energetic substrate to the muscle, myalgias and stiffness. We present a case report of a patient with McArdle's disease and we comment the diagnostic procedures and current therapeutic options.

Adult↗
PubMedDate not supplied

[Upper digestive hemorrhage in a patient with von Recklinghausen neurofibromatosis].

Neurofibromatosis (Von Recklinghausen's disease) is uninherited as an autosomal dominant trait. It is characterised by the development of tumors in diverse sites, which may be benign or malignant. The case of a 39 year old woman with Von Recklinghausen's disease is discussed. She presented with a 3 year history of episodes of melaena and iron deficient anaemia. Mesenteric angiography demonstrated a hypervascular tumour in the jejunum. It was surgically excised with an anatomopathological diagnosis of neurofibroma.

Adult↗
PubMedDate not supplied

[Acalculous cholecystitis in Schöenlein-Henoch syndrome. Apropos of a case].

We describe the case of a 51 year-old man affected of relapsing bouts of abdominal pain and hematuria, who began acutely with pain in the right upper quadrant, fever, hematuria, arthralgias and purpura on the lower extremities; ultrasonography revealed the existence of acalculous cholecystitis. The lack of response to intravenous antibiotherapy and the clinical association of cholecystitis to the renal, cutaneous and articular manifestations, oriented to the diagnosis of Schöenlein-Henoch vasculitis; thereafter, the response to steroids was successful and immediate. The etiologic diagnosis of this case of acalculous cholecystitis based on clinical aspects, avoid the surgical therapy and the possible morbidity that this procedure can produce.

Arthralgia↗