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J Rózański

Publications and source records attributed to J Rózański.

At least 19 recordsLinked to original sources
PubMed2006

Circulating adhesion molecules during kidney allograft reperfusion.

Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant recipients, including 13 cases of delayed graft function (DGF) and 11 cases of acute graft rejection (AR). Plasma concentrations of E-selectin, VCAM-1 and ICAM-1 after 3 min of reperfusion were significantly higher than in the iliac vein before reperfusion. There was no statistically significant difference between patients with and without DGF as regards E-selectin, VCAM-1 and ICAM-1 concentrations in the iliac vein before and in the renal vein after 3 min of reperfusion. Concentrations of adhesion molecules in the iliac vein before reperfusion and in the renal vein after 3 min of reperfusion did not differ significantly between patients with and without AR except for ICAM-1 iliac vein concentration which was significantly increased in AR patients. Plasma levels of E-selectin, ICAM-1 and VCAM-1 were increased after kidney allograft reperfusion. Moreover, elevated serum levels of ICAM-1 before transplantation correlated with subsequent acute kidney allograft rejection. The results suggest that elevated ICAM-1 levels may be implicated in acute graft rejection.

Cell Adhesion Molecules↗
PubMed2005

Cyclosporine and sirolimus interaction in a kidney transplant patient.

Cyclosporin A and sirolimus are becoming commonly used in immunosuppressive treatment in organ transplant patients. The drugs are both metabolized by cytochrome P450 3A4 and are substrates of P-glycoprotein. Thus, interaction between these drugs is possible. The case reported here illustrated that clinicians should be aware of this important drug-drug interaction.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed2005

Frequencies of the common promoter polymorphisms in cytokine genes in a Polish population.

Common polymorphisms in cytokine genes, widely distributed in many populations, may affect gene transcription, leading to individual variations in cytokine levels. Some of those polymorphisms were associated with the risk of graft rejection or autoimmune and parasitic diseases development as well as treatment outcome. In the current study the frequencies of promoter polymorphisms in genes encoding interleukin-2 (-330 G/C), interleukin-4 (-590 C/T), interleukin-6 (-174 G/C), interleukin-10 (-1082 G/A, -592 C/A) and TNFalpha (-307 G/A) have been studied in a sample of 205 unrelated healthy Polish subjects of Caucasian origin. The frequencies of the determined cytokine alleles were as follows: interleukin-2 (-330 G/C): T -64.9%, G -35.1%; interleukin-4 (-590 C/T): C -79.8%, T -20.2%; interleukin-6 (-174 G/C): G -53.4%, C -46.6%; interleukin-10 (-1082 G/A, -819 G/T, -592 C/A): GCC -44.1%, ACC -32.0, ATA -23.9%; TNFalpha (-307 G/A): G -85.1%, A -14.9%. We also compared our results with other populations studied to date, describing some significant differences.

Adult↗
PubMed2004

The role of echocardiography in diagnosing double chambered right ventricle in adults.

OBJECTIVE: To evaluate the utility of echocardiography in diagnosing double chambered right ventricle (DCRV) in adults. DESIGN: A retrospective study. SETTING: Department of Congenital Heart Diseases and Department of Cardiac Surgery, Institute of Cardiology, Warsaw, Poland. PATIENTS: 32 patients, mean age 32.5 years, 21 female, and 11 male. INTERVENTION: Transthoracic (TTE) and transoesophageal (TOE) echocardiographic examination in patients with suspected DCRV. MAIN OUTCOME MEASURES: Direct inspection during surgical treatment of 28 patients diagnosed as having DCRV as an isolated lesion or associated with other pathologies. RESULTS: Echocardiography allowed the final diagnosis of DCRV in 26 patients (81%) out of 32 studied. TTE was diagnostic in 5 (15.6%) whereas TOE was diagnostic in 21 of 21 studied by this technique. Of 6 patients with negative TTE, DCRV was identified by cardiac catheterisation in 3 and directly during surgery in the remaining 3. Of 26 patients diagnosed by echocardiography, the anomalous muscle bundle was discrete in 20 (77%) and diffuse in 6 (23%). In 23 patients (88%) right ventricular outflow obstruction was localised low in the right ventricle, and in the remaining 3 (11.5%), the obstruction was localised high in the right ventricle. Abnormal bundles localised high were discrete, bundles localised in the lower part of right ventricle were discrete in 17 (74%) and diffuse in the remaining 6 (26%). DCRV was an isolated lesion in only 2 patients (6.2%). In all subjects surgical inspection confirmed echocardiographic data. CONCLUSIONS: Echocardiography was very useful to diagnose DCRV in adults as well as to identify its anatomic type. Comparing two different approaches, TOE better defines the entire scope of pathology, including estimation of the resultant systolic pressure gradient within the right ventricular cavity.

Adolescent↗
PubMed2003

Factors that impact on immediate graft function in patients after renal transplantation.

Kidney transplantation has become therapy of choice for patients with end-stage renal failure. However, many factors may cause graft rejection or delayed graft function, both of which decrease the prognosis for graft survival. For transplantologists the most important endeavor is to eliminate factors responsible for shortening graft function and to find those predictive of immediate graft function. The aim of the study was to investigate which factors influence early graft function. We retrospectively reviewed 442 renal transplant patients performed between 1990 and 1995 in two Szezecin units. All patients received an identical immunosuppressive drug schedule. Three hundred twelve patients who displayed immediate graft function were included in the study group to analyze donor and recipient age and sex, etiology of ESRD, HLA compatibility AB0 and Rh compatibility cold ischemia time, warm ischemia time, antileukocytes antibodies (PRA), and period of dialysis therapy before transplantation. We observed statistical significance for HLA and AB0 compatibility, younger donor age, and shorter cold ischemia time as the most important factors predictive of early graft function and an improved prognosis for graft survival.

ABO Blood-Group System↗
PubMed2003

The Fc gamma RIIa polymorphism in patients with acute kidney graft rejection.

The Fc gamma RIIa receptors are the most widely distributed of the three classes of Fc receptors and expresses an allelic polymorphism. This polymorphism may modulate the immune response and may be a factor for some diseases. The aim of the study was to evaluate the association between the Fc gamma RIIa polymorphism and acute kidney graft rejection. The study was carried out in 115 kidney allograft recipients. The frequency of acute kidney graft rejection was similar in relation to Fc gamma RIIa genotypes. We suggest that Fc gamma RIIa polymorphism is not important risk factor for acute kidney graft rejection susceptibility.

Acute Disease↗
PubMed2000

Myocardial perfusion and function of the systemic right ventricle in patients after atrial switch procedure for complete transposition: long-term follow-up.

OBJECTIVES: Our purpose was to assess the right ventricular (RV) function and identify patients with RV impairment long after the Mustard or Senning operation. BACKGROUND: Systemic ventricular failure can cause myocardial perfusion abnormalities in thallium scintigraphy correlating with hemodynamic deterioration. METHODS: Myocardial perfusion at rest and at peak exercise was assessed in 61 patients, aged 7 to 23 years in mean time 10.0 +/- 2.9 years after surgery using technetium-99m methoxyisobutyl isonitrile single-photon emission computed tomography. Ventricular function was assessed by first-pass radionuclide angiography at rest. Exercise capacity was determined with a modified Bruce protocol. RESULTS: The mean RV ejection fraction was 36.1 +/- 7.7%, and left ventricular (LV) ejection fraction was 52.1 +/- 9.4%. Moderate or severe perfusion abnormalities on the rest scan were observed in 20 patients (33%). On exercise perfusion worsened in another 13 patients (21.3%). Patients with perfusion defects on stress scan had significantly lower RV and LV ejection fraction (33.2 vs. 39.4%; p = 0.002 and 49.2 vs. 55.5%; p = 0.01, respectively). They were also older (16.6 vs. 13.0 years; p = 0.002), operated on at an older age (4.0 vs. 2.4 years; p = 0.05) and had longer follow-up (12.5 vs. 10.5 years; p = 0.003). CONCLUSIONS: Myocardial perfusion defects are common findings in patients in long-term follow-up after atrial switch operation. Despite excellent exercise tolerance, the extent of myocardial perfusion abnormalities correlated well with impaired RV and LV function, and greater perfusion defects were seen more frequently in older patients with longer follow-up. It is likely that myocardial perfusion defects could be a sensitive predictor of systemic ventricular impairment.

Adolescent↗
PubMed2000

[The effect of hyperlipidemia on metabolism, distribution and secretion of lidocaine in patients with primary hyperlipidemia].

High prevalence and coexistence of lipid disturbances and ischaemic heart disease (IHD) presents a new challenge to safe and effective pharmacotherapy in this group of patients. Ventricular arrhythmias are common in patients with IHD and lidocaine is the principal drug for their management. The aim of this study was to analyze the pharmacokinetics and pharmacodynamics of lidocaine in primary hyperlipidemia, depending on the type of hyperlipidemia, and to draw conclusions concerning therapeutic safety. The study was performed in 31 subjects, aged 25-58 years (mean 43.5 years), divided into four groups. The control group included 8 subjects aged 28-52 years. Group 2 included 8 patients aged 29-54 years with hypercholesterolemia. Group 3 included 8 patients aged 25-58 years with hypertriglyceridemia, and group 4 included 7 patients aged 38-58 years with mixed hyperlipidemia. The concentration of lidocaine and its main metabolite, monoethylglycinexylidide (MEGX), was measured. A single dose of lidocaine was administered intravenously during 2 minutes. Blood was sampled from the cubital vein before (0) and 5', 15', 30', 60', 120', 240', 360' and 600' after injection. The concentrations of lidocaine and MEGX were established using high-pressure liquid chromatography (HPLC)--Tab. 1-5. It was found that hyperlipidemia influences the pharmacokinetics and pharmacodynamics of lidocaine. The pattern depends on the type of hyperlipidemia. The main difference in the pharmacokinetics of lidocaine in patients with hypercholesterolemia is a greater volume of distribution and longer terminal half-life of the drug. In conclusion, dosage modification is necessary in hypercholesterolemia.

Adult↗
PubMed1999

[Long-term follow-up of supraventricular tachyarrhythmia in adult patients with secundum atrial septal defect before and after surgery].

The frequency of arrhythmias was determined pre- and postoperatively in adult patients with secundum atrial septal defect. The study group consisted of 224 pts who had undergone surgical repair of ASD II in between 1987-1993. The mean postoperative follow-up was 7.5 y. The group (160 F, 64 M, aged 17-66 y) was divided on 3 subgroups: I--age under 20 y--27 pts, II--20-40 y--131 pts, III--over 40 y--66 pts. We analysed pre- and postoperative parameters: 1) arrhythmias in the 24-h Holter recording, 2) pulmonary hypertension (PASP-Doppler), 3) coexisting diseases, 4) functional class of heart failure (NYHA). Most common abnormalities found were supraventricular tachyarrhythmias (22.8 pre- and 40.6% postoperatively). There was significant increase in frequency of arrhythmias after surgery in the subgroups II and III. Arrhythmias were most frequent in patients with coexisting arrhythmogenic diseases.

Adolescent↗
PubMed1999

[Pulmonary hypertension in adult patients with secundum atrial septal defect before surgery and in long-term follow-up].

The aim of the study was to determine pre- and postoperative systolic pulmonary pressure in adult patients with ASD II. The study group consisted of 224 pts who had undergone surgical repair of ASD II in between 1987-1993. The mean postoperative follow-up was 7.5 y. The group (160 F, 66 M aged 17-66 years) was divided on 3 subgroups: age under 20 y--27 pts; 20-40 y--131 pts; and older then 40 y--66 pts. We analysed pre- and postoperative parameters: pulmonary hypertension (PASP-Doppler) and functional class (NYHA). Preoperative pulmonary pressure was 35-50 mm Hg in 69 pts (30.8%) of the group, and over 50 mm Hg in 29 (12.9%). In long-term follow-up of 98 (43.8%) operated patients with coexisting pulmonary hypertension, significant reduction of pulmonary pressure was observed in all patients, even in patients over 40 y. Functional class of heart failure NYXHA improved as well in all patients.

Adolescent↗
PubMed1998

Ischemic neurologic event in a child as a result of ventricular septal aneurysm.

Aneurysm of the interventricular septum without a shunt was found by means of transthoracic echocardiography in a 6-year-old boy with acute hemiparesis. Until the time of the incident, he had been healthy. The aneurysmal sac contained 2 clots, presumably resulting in the ischemic cerebral infarct. On the basis of the echocardiographic scan, successful surgery was performed. To the best of our knowledge, this is the first report describing such dramatic sequelae of interventricular septal aneurysm.

Brain Ischemia↗
PubMed1993

[Aortic-left ventricular tunnel--description of two cases].

This is a very rare congenital anomaly, which clinically imitates aortic insufficiency and therefore should be kept in mind by the cardiologist. Only an early precise diagnosis and proper surgical treatment will result in a good long-term prognosis. We have diagnosed and treated two patients, four and five years old, referred to us with a diagnosis of aortic insufficiency. Our final assessment was based on an obligatory cine-angio study, since a certain percentage of patients with this anomaly have concomitant lesions in the cardio-vascular system, which should be precisely detected. A brief differential diagnosis and discussion concerning different surgical techniques are presented. In our two cases obliteration of the tunnel using a Dacron patch inserted vertically in the tunnel with closure of both ostia was performed. This technique seems to be superior compared to the previous one in terms of preventing the progressive destruction of the aortic valve. All the authors agree that early surgical treatment is indicated before the left ventricle becomes dilated and the aortic valve significantly damaged. Two years post surgery our patients are in very good condition with: no signs and heart failure, a gradual diminution of the left ventricular cavity and satisfactory function of the aortic valve.

Aortic Valve Insufficiency↗
PubMed1992

[Recurrent bacterial endocarditis with involvement of the tricuspid valve after surgical correction of congenital heart defect].

A case of recurrent tricuspid valve endocarditis after surgical closure of ventricular septal defect is presented. Intensive medical treatment lasting nearly ten years completely failed. There were still vegetations attached to the septal leaflet of the tricuspid valve with positive cultures (Ps. aeruginosa). Persistent sepsis without signs of heart failure required surgical intervention. Tricuspid valvuloplasty with excision of infected patch was successfully performed. Six months later the patient remained symptomless.

Adult↗