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Biomedical subjects

J Rózga

Publications and source records attributed to J Rózga.

18 recordsLinked to original sources
PubMed1989

[Alcohol-induced liver cirrhosis as a cause of portal hypertension].

Basic data on pathomorphology and symptomatology of the alcohol-induced liver cirrhosis accompanied by portal hypertension are discussed. Respective data were compared with the group of cirrhotic patients not abusing alcohol. A high percentage of encephalopathic disorders and nearly 50% of the patients suffering from the hemorrhage from esophageal varices were the first sign of the cirrhosis in both groups. Despite hemorrhage from esophageal varices a few patients obtained surgical help preventing recurrence of the hemorrhage. Liver functional reserve, incidence of encephalopathies and the degree of liver involvement are in favour for non-alcohol cirrhosis. Inflammatory process in the liver, splenomegaly and hypersplenism were more frequent in the liver cirrhosis of non-alcohol origin.

Adult↗
PubMed1989

[Effect of phototherapy on the frequency of the use of exchange transfusion in the treatment of neonatal jaundice].

The authors analysed an incidence of performed exchange blood transfusions at the newborn babies ward prior to and after introduction of phototherapy into practice. This analysis included the causes of jaundice in newborn. The study included the causes of jaundice in newborn. The study involved 8,937 newborn babies delivered between 1981 and 1985. Prior to phototherapy (period between January, 1981 and July, 1980), 45 blood transfusions and 9 retransfusions were performed. During the period II (between July, 1983 and December, 1985), i.e. phototherapy, 30 blood transfusions and 1 retransfusion were effected despite of the higher number of delivered babies. The obtained results have shown favourable effect of the phototherapy in jaundice of perinatal period, especially in jaundice unconnected with blood Rh factor conflict and in premature babies. Phototherapy decreased the number of performed transfusions and retransfusions.

Exchange Transfusion, Whole Blood↗
PubMedDate not supplied

The role of reactive oxygen metabolites in the pathogenesis of ulcerative colitis: a speculative synthesis.

The lesson learned from the studies on oxygen-derived free radicals and several well recognized metabolic and morphologic disturbances associated with IBD and intestinal ischaemia strongly suggests that oxyradicals can be an important mediators of colonic injury in UC. Instead of summarizing of what has been said, a schematic illustration of different pathogenetic factors which can way a vicious circle of destruction is proposed. Unfortunately, a new and specific therapy of UC is as yet not available, because the locus of primary lesion is poorly understood. It is, however, reasonable to search for a complex therapy which could break a chain of pathological processes at several subunits functioning in either positive or negative feed-back loops. In my belief, complementary treatment with free-radical scavengers is to be tested as a new and potentially efficacious modality. In this respect, preliminary encouraging results obtained with local administration of SOD encapsulated in liposomes deserve attention.

Colitis, Ulcerative↗
PubMedDate not supplied

The effect of pancreatic and intestinal venous blood on hepatic atrophy and compensatory hyperplasia in the rat.

Hepatotrophic effect of pancreatic and intestinal venous blood was studied in rats with mesocaval or distal splenocaval shunt following ligation of a branch of the portal vein supplying 70% of liver mass. Because 2/3 of liver mass was deprived of portal flow the nonligated liver lobes were not hypoperfused due to shunt procedure. During the first three postoperative days the DNA synthesis, mitotic index, and changes in relative weights were measured in both ligated (atrophied) and nonligated (compensatory hyperplasia) parts of the liver. It was found, that the restorative capacity of the liver existed in rats with selective portasystemic shunts. The stimulus to growth was greater in lobes supplied by intestinal venous blood compared to those perfused by pancreatic effluent. The increase in DNA synthesis occurred in lobes undergoing atrophy and the intensity of this response was also dependent on type of shunt since recirculation of intestinal blood by way of the hepatic artery inhibited atrophy to a greater extent than pancreatic venous effluent. Although the patency of arterial branches was confirmed the ligated lobes showed necrotic lesions. Systemic recirculation of intestinal venous blood far more inhibited necrosis than pancreatic venous blood.

Animals↗