PubMed Health⌕ Search

Biomedical subjects

J Raafat

Publications and source records attributed to J Raafat.

10 recordsLinked to original sources
PubMed1996

Prevalence of HTLV type I infection in Iran: a serological and genetic study.

Several publications describe the presence of the human T cell lymphotropic virus type I (HTLV-I) in Jewish individuals born in Mash-had, Iran. We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area: Gonbad-Kavous. Seven hundred and seven serum samples from Mash-had (694 healthy individuals and 13 patients with lymphoma) and 90 from Gonbad-Kavous were tested for HTLV antibodies by gelatin particle agglutination assay (PA) and confirmatory Western blots (WBs). Seropositive rates of 3.0% (21 of 694) in Mash-had, 0% (0 of 90) in Gonbad-Kavous, and 100% (13 of 13) in lymphoma cases were observed. HTLV-I DNA sequence were amplified by polymerase chain reaction directly from the fresh PBMCs of seropositive individuals. Phylogenetic analysis of the viral DNA sequence indicated that the HTLV-I present in Mash-had belong to the HTLV-I cosmopolitan clade. Altogether, these data indicate that Mash-had, located in northeastern Iran, is a newly recognized endemic center for HTLV-I.

Amino Acid Sequence↗
PubMed1980

Combination chemotherapy for advanced squamous cell carcinoma of the head and neck.

Fifteen patients with advanced squamous cell carcinoma of the head and neck were treated with the six-drug Price-Hill regimen (vincristine, bleomycin, methotrexate, hydrocortisone, 5-fluorouracil, and leucovorin). Only two partial remissions were obtained, and the regimen produced moderate toxicity. Our results are not as favorable as those of Price and Hill.

Adult↗
PubMed1980

Combination chemotherapy for advanced cutaneous T-cell lymphomas.

Seven patients with advanced cutaneous T-cell lymphomas were treated with a combination chemotherapy regimen of vincristine, doxorubicin (Adriamycin), bleomycin, methotrexate, leucovorin factor, 5-FU, and hydrocortisone. All patients had an objective response but only one had a complete clinical remission. Our results are compared to other regimens reported in the literature.

Adult↗
PubMed1979

Karyotype studies of cutaneous T cell lymphoma: evidence for clonal origin.

Neoplastic lymphocytes from 3 patients with widespread cutaneous T cell lymphoma were karyotyped, using a chromosome banding technique. None of the patients had previously received chemotherapy. Morphologically homogeneous populations of abnormal T cells were available from 2 distinct body regions of 2 of the individuals and from the bone marrow of the third. Karyotypes from each of the 3 patients indicated monoclonality of their lymphoma. These observations suggest that extracutaneous dissemination of cutaneous T cell lymphoma involves spread of neoplastic cells derived from a single clone. If future studies can demonstrate that those neoplastic T cells actually localized in the skin are also progeny of a single malignant cell, a widely accepted concept that cutaneous T cell lymphoma is of multifocal origin will have to be reexamined.

Adult↗
PubMed1979

Antithymocyte globulin in the management of cutaneous T cell lymphoma.

Four patients with cutaneous T cell lymphoma were treated with iv administered horse antithymocyte globulin. Evidence of a beneficial response was obtained in three of the four patients. Limited sensitivity of neoplastic T cells to complement-mediated lysis in the presence of the antithymocyte globulin was identified, suggesting that other mechanisms may be responsible for the observed clinical responses.

Aged↗
PubMed1978

Metastatic Ewing sarcoma to the heart simulating adriamycin cardiotoxicity.

A 20-year-old man with metastatic Ewing Sarcoma developed severe congestive heart failure. Because he had been treated with a large amount of Adriamycin, the diagnosis was initially thought to be Adriamycin cardiotoxicity. However, ante- and post-mortem studies revealed the presence of massive cardiac metastases. At post-mortem, there was no evidence of Adriamycin cardiotoxicity. This case emphasizes that cardiac metastases must be considered in the differential diagnosis of heart failure in patients treated with Adriamycin.

Adult↗
PubMedDate not supplied

Sarcoma in Iran.

PURPOSE: To review the clinical characteristics of 1470 sarcoma cases and to define the factors in patients that predict out come, relapse and survival. METHODS: Retrospective analysis of the database for the period 1991-2002, focusing on demographic, tumor related and treatment related variables, relapse free survival (RFS) and overall survival (OS) using the Kaplan- Meier method. Statistical significance was evaluated using the chi square and t- tests for univariate influence and a Cox regression model for multivariate influence. RESULTS: Mean age was 30 years. The male to female ratio was 3/2 and 23% of the cases were under 16 years of age. Median tumor diameter was 10.5 centimeters. The bone to soft tissue sarcoma ratio was 3/1 in children and 1/3 in adults. Osteosarcoma, Ewing's tumours and rhabdomyosarcomas accounted for 83% of childhood tumors. In adults osteosarcomas, synovial sarcomas and malignant fibrous histocytomas (MFHs) were the most common subtypes. Mean follow up time was 56 months. Of the total, 25% had initial metastasis, 86% received chemotherapy and 41 % underwent radiotherapy. The main prognostic factors for survival were tumor size, margin of surgery, neurovascular involvement in the pathological report, initial metastasis and no complete response to first therapy. Adjuvant radiotherapy, small tumor size, curative surgery with chemotherapy and free surgical margins were significantly associated with reduced recurrence. CONCLUSION: Our patients are characterised by diagnosis with a large tumor size, advanced stage of disease and short survival. A complete response to primary therapy is the main independent variable for overall survival. Earlier diagnosis and an experienced team including surgical, medical and radiotherapy oncologists are needed for a better response and longer survival of patients.

Adolescent↗
PubMedDate not supplied

Gastric carcinoma: 5 year experience of a single institute.

PURPOSE: Gastric cancer (GC) is the most common cause of cancer death registered in cancer institute. Background clinical information is important for cancer prevention and therefore we here present characteristics and outcome of GC patients, more than half coming from northern parts of Iran. MATERIALS AND METHODS: we retrospectively studied records patients with pathologic diagnosis of GC referred to the Medical Oncology Department of the Cancer Institute from 1998 to 2003. RESULTS: Four hundred and thirteen patients were registered with GC with the average age of 58 and a male to female ratio of 3/1. Tumor stage based on AJCC was stage 2(12.5%), stage 3(22%), stage 4(63%) and 2% unknown. Most common site of involvement was cardia (43%). Median survival time of all patients (with or without treatment) was 10 months overall. Gastrectomy was performed for 214 patients(39% with positive surgical margins), and 175 of the gastrectomised patients received chemotherapy. Median survival with surgery only was 7 months but 20 months with both surgery and chemotherapy. Only 21 patients received neoadjuvant chemotherapy. Median survival of patients who had response to preoperative chemotherapy was 30 months. By multivariate analysis lower extent of disease (p=0.0024), free surgical margin (p=0.0017), and chemotherapy (p=0.001) were associated with better prognosis. CONCLUSIONS: Only curative resection with free margins was associated with a survival benefit in this study. More than 80% of patients were diagnosed in locally advanced or metastatic stage of disease and even with neoadjuvant chemotherapy and salvage surgery the outcome was poor. Clearly more efforts need to be given to early detection of lesions to allow a better cure rate.

Adenocarcinoma↗