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Biomedical subjects

J Radó

Publications and source records attributed to J Radó.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Dobutamine stress echocardiography: a new possibility in the diagnosis of coronary disease].

Authors performed dobutamin stress test since 1987 and combined their examinations with 2D-echocardiography in case of suspected coronary artery disease since October 1991. In this study they report on their experiences obtained in the course of the first 32 examinations. The results of the dobutamine stress echocardiography were analysed on the basis of coronarography which was performed in every patient. According to their observations dobutamine stress echocardiography has very good sensitivity and specificity and it is practically a harmless method, but as it requires instruments, assistants, time and work. Authors recommend the method first of all as a complementary to the physical loading method as well as alternative loading examination.

Coronary Disease↗
PubMed1993

[Pseudophaeochromocytoma (hypertensive crisis as a result of beta receptor hypersensitivity?)].

The diagnosis of phaeocromocytoma could be excluded in a 57 year-old man suffering from "typical" hypertensive paroxysms by using modern standardized technics. The presented disorder which has been named pseudophaeochromocytoma may include different pathogenetical entities. In the observed case the background of the disorder was thought to be "beta-receptor hyperresponsiveness" which has been confirmed by the determination of the urinary catecholamine excretion as well as by the introduction of a new isoproterenol infusion method. In response to beta-blocking agents (which are contraindicated in phaeochromocytoma) no further hypertensive crises occurred, resulting in a dramatic improvement of the patient's condition.

Adrenal Gland Neoplasms↗
PubMed1992

[Circadian rhythm of blood pressure in hypertension treated with enalapril and other drugs].

Twenty-four-hour "ambulatory blood pressure monitoring" (ABPM) was performed during the day at every 30 min and during the night at every 60 min in 38 persons admitted to the hospital. The subjects were divided into four groups: Group 1. healthy subjects (11); Group 2. essential hypertensive patients (7) before and during enalapril treatment; Group 3. patients with essential hypertension (10) treated with different antihypertensive drugs and Group 4. renal patients treated as in Group 3. Normal circadian rhythm was found in the healthy subjects and in the patients with essential hypertension, but no rhythm could be demonstrated in the renal patients. The high blood pressure decreased in response to enalapril in 7 patients without any decrease in the circadian rhythm. It was concluded that antihypertensive therapy does not abolish the circadian rhythm if there is any--and does not restore if it is lacking. The chances of the diagnostic use of circadian blood pressure rhythm are not impaired by the antihypertensive treatment.

Antihypertensive Agents↗
PubMed1992

[Noninvasive imaging of the proximal coronary arteries by transesophageal echocardiography].

Authors give an account of their experiences about the visualization of the proximal coronary arteries on the basis of the transesophageal echocardiographic examination of 45 patients. According to their observations the left main coronary artery, the bifurcation, the left anterior descending artery and the circumflex coronary artery were well visualized in 40 patients. With the help of pulsed Doppler-echocardiography the Doppler flow velocity spectrum of the coronary flow can be detected, which could be analysed in 25 patients. At the same time the visualization of the right coronary artery is less sensitive, valuable images could be detected only in 12 patients. The technique of the TEE visualization of the proximal coronary arteries is described. TEE seems to be a promising approach to the morphologic evaluation of the proximal coronary arteries and for functional pathophysiologic examinations of coronary blood-flow.

Coronary Circulation↗
PubMed1992

[Rhabdomyolysis in a medical student induced by body-building exercise (rhabdomyolysis following acute muscular exertion)].

A medical student sportsman had been admitted to the hospital because of weakness and painful swelling of the muscle as well as dark urine appearing after carrying out an excessive body-building performance. On the basis of indirect evidences pigmenturia "per exclusionem" was a manifestation of urinary myoglobin excretion. The development of an "acute exertional rhabdomyolysis" was confirmed by the increased serum enzyme levels and myoglobinuria. The outcome of the illness was fortunate, as acute renal failure could be avoided. On the basis of survey of the literature it can be stated, that this presumably frequently occurring, but rarely recognized disease may have importance from clinical, sporting medicine and pathophysiological point of view.

Adult↗
PubMed1991

[Lithium-induced chronic water-metabolism disorder (nephrogenic diabetes insipidus)].

Lithium may induce all clinical physiological abnormalities of the polydipsia- polyuria syndrome. Authors describe a 61-year-old woman patient in whom permanent disturbance of the water metabolism, nephrogenic diabetes insipidus (NDI) was caused by lithium treatment, lasting longer than 10 years. The partial resistance of the fluid disturbance to vasopressin has been investigated by the administration of supramaximal doses of dDAVP. Considering the known antidiuretic effect of indomethacin, authors compared antidiuruetic activity of indomethacin and piroxicam (Hotemin) by studying standard parameters of water metabolism/free water clearance ect.) It was found that piroxicam, on mg basis a more effective antiinflammatory compound, was less antidiuretic then indomethacin. It was concluded, that there is no close parallelism between the structure and antiinflammatory and antidiuretic activity of nonsteroid antiinflammatory drugs. In the opinion of authors nonsteroid antiinflammatory drugs may have a role in the treatment of lithium-induced NDI, though, the establishment of the safety use of such therapy requires further studies.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1989

[Partial diabetes insipidus and ascitic liver cirrhosis in a patient].

The occurrence of hepatic cirrhosis with ascites and diabetes insipidus in the same patient is described. The stimulability of residual vasopressin was confirmed by water deprival and the partial vasopressin deficit by the administration of dDAVP. Water loading test referred to the possibility of suppression of residual vasopressin. Studying the specific renal functions in diets of different sodium content following the administration of dDAVP and diuretics, the diuretic without adding ADH was found to be the best therapy for these patients. Reviewing the literature the authors are taking into consideration the difficulties of differential diagnostics and the mechanisms which may explain the inhibiting effect of the liver disease on the polyuria associated with diabetes insipidus.

Aged↗
PubMed1988

[Hann syndrome: remission of diabetes insipidus by functional failure of the anterior pituitary gland].

We know that the symptoms of diabetes insipidus develop only in a state of functional capacity of the neurohypophysis. The symptomatology of diabetes insipidus disappears, when the pars anterior of the hypophysis is destructed, whereas the two lobes have antagonistic effects in respect of water metabolism. Describing two cases the authors remember to F. v. Hann as the first describer of this syndroms' complex and postulate the corresponding nomination.

Aged↗
PubMed1988

Monotherapy and combined treatment with captopril.

The effectiveness of captopril, the dose-response relationships, the influence of diuretics on the effective dose of captopril, the possible combinations of captopril with other antihypertensive agents as well as the clinical value of monotherapy and combined treatment have been investigated in 48 patients with hypertension. This paper summarizes the data obtained in the course of several special clinico-pharmacological studies during a 4 year period (1982-1986). Captopril proved to be an antihypertensive agent with a wide therapeutic spectrum. As a single agent it was used especially in geriatric cases. Of the antihypertensive agents, diuretics have been combined with captopril most frequently but it has been concurrently administered with practically all the other antihypertensive drugs. Captopril appeared to be a safe agent without significant side effects. An increase in serum potassium levels by captopril were seen not infrequently; its advantages, disadvantages, prevention and mechanisms have been dealt with in detail.

Aged↗