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Biomedical subjects

J Radovich

Publications and source records attributed to J Radovich.

10 recordsLinked to original sources
PubMed1979

Immunosuppression by a mouse tumor resembles antigenic competition.

The intraperitoneal injection of gamma-radiated, UV-radiated, or unradiated P-815 tumor cells into syngeneic or allogeneic mice suppressed the immune response to a subsequent intraperitoneal injection of sheep erythrocytes in a manner similar to the suppression caused by the injection of manner similar to the suppression caused by the injection of horse erythrocytes and termed antigenic competition. In both cases, the greatest suppression occurred when the sheep erythrocytes were injected at the same site (intraperitoneal) as the tumor or antigen several days after the tumor or antigen and in a dose of 10(8) erythrocytes or less.

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PubMed1976

Activation of transplant immunity: effect of donor leukocytes on thyroid allograft rejection.

The survival of thyroid allografts in mice was prolonged by either holding the grafts in vitro culture for 20 to 27 days or by cobalt-60 irradiation of the donor 2 days before transplantation with or without the intravenous injection of colloidal carbon just before removing the thyroid from the donor. In both cases the rejection process was restored by an intravenous injection of recipients with living peritoneal exudate cells (50 to 80 percent macrophages) syngeneic to the thyroid donor.

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PubMed1967

Antigenic competition: cellular or humoral.

The injection of one antigen into mice inhibited the response to a second when 1 to 10 days separated the two injections. When the same type of inhibition was attempted in gamma-irradiated mice reconstituted with normal spleen cells, the inhibition was greater in mice receiving 50 million spleen cells than in those receiving 10 million. The results are interpreted as favoring a humoral mechanism of inhibition.

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