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J Radtke

Publications and source records attributed to J Radtke.

33 records · Page 2Linked to original sources
PubMed1988

Phosphorylation affects the DNA affinity of the nuclear protein 24/7 from human tumor cells.

In the present study we investigated the binding behavior of nuclear proteins from human tumor cells to human placental DNA coupled on CNBr-activated Sepharose. When nuclear proteins soluble in 5 M urea prepared from serum-stimulated cells and containing the majority of the nonhistone proteins were applied onto a dsDNA column, next to several other proteins one prominent group consisting of at least 2 distinct proteins with a pI at 7 and a molecular mass near 24 kDa bound to DNA. The DNA-binding ability of one of them is lost on phosphorylation and is recovered after dephosphorylation using alkaline phosphatase. Additionally, normal human fibroblasts taken as controls exhibit comparatively low levels of these 24/7 proteins, indicating a particular function in tumor cells.

DNA-Binding Proteins↗
PubMed1986

[Results of nuclear spin tomography of facial bone tumors].

We examined 21 patients with tumours of the mouth, one with tumour involvement of the facial skeleton and three with lymph node involvement in the upper neck, by nuclear tomography. Twenty patients with carcinomas of the mouth were also examined by CT. Nuclear tomography was superior to CT in showing the extent of the tumour; in ten patients the extent of the tumour could not be accurately determined, since there was no clear demarcation from normal tissue. Amongst our patients, nuclear tomography was also superior for showing lymph node metastases. Computed tomography is better at showing bone infiltration. Our results indicate that nuclear tomography is better than CT for showing the tumour and lymph nodes. If there is a suspicion of bone involvement, CT should be used in addition.

Fibroma↗
PubMed1980

[Localization and distribution of calcium salt in gallstones. A scanning electron microscopic study with energy-dispersive elemental analysis (author's transl)].

The surface of 68 fractured gallstones (28 patients) was investigated by SEM with energy-dispersive elemental analysis to show the topography of calcium salts. The localization of calcium salt is important with regard to chemolitholysis of calcium-containing cholesterol gallstones. The stones of 15 patients showed a concentration of calcium in the nucleus: in 4 the calcium salt was concentrated in the shell of the stone. In two more cases it was determined that calcium was present in both nucleus and shell. In seven it was impossible to place the stones in one of the above classes. Calcium salt in the shell seems to impede lysis by chenodeoxycholic acid; in these stones there is a small amount of insoluble calcium salt in the nucleus which remains after possible lysis of a cholesterol shell. The most appropriate stones for therapy with chenodeoxycholic acid are apparently those which harbor calcium salts with diffuse localization, so that no distinct nucleus no shell can be seen.

Aged↗
PubMedDate not supplied

[Fibromatosis colli--a benign tumor of the neck in diagnosis and therapy].

Fibromatosis colli is a benign tumor of infancy, and although prognosis is usually good, it is the most frequent cause of congenital torticollis. The clinical picture, sonography, or, if required, CT scans, permit a clear diagnosis. Invasive diagnostic and therapeutic measures should be avoided and restricted to those cases, where a malignancy is suspected with good reason or where local complications due to bulk shifts and compression are anticipated. Even after the usually spontaneous remission of the tumor torticollis may develop later on so that accompanying exercise therapy should be provided from infancy to school age.

Diagnosis, Differential↗
PubMedDate not supplied

[Lymphomas with oromaxillofacial manifestations].

Out of a total of 48 patients with malignant lymphomas of the maxillofacial area, only 2 patients had been referred with a correct tentative diagnosis within a period of 11 years. In 83% the main symptom was painless swelling of the affected structures. Almost 50% of the extranodal manifestations were found in the mouth.

Adult↗
PubMedDate not supplied

[Hereditary intraoral fibromas and exostoses].

The formation of exostoses of the upper and lower jaw is a frequent finding and should be treated for esthetic and functional reasons. An unusual case of severe palatal fibromas and concomitant vestibular exostosis in a 36-year-old woman is presented. Identical symptoms are found in the patient's father and her 8-year-old daughter.

Adult↗