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Biomedical subjects

J Raoul

Publications and source records attributed to J Raoul.

7 recordsLinked to original sources
PubMed1998

Salvage esophagectomy after unsuccessful curative chemoradiotherapy for squamous cell cancer of the esophagus.

Surgery was performed on 6 patients after unsuccessful chemoradiotherapy for squamous cell cancer of the esophagus. The operation was very difficult due to post-irradiation sequelae in 5. The postoperative period was uneventful in 4 patients. Median intensive care unit stay and hospitalization were 5 and 47 days, respectively. Survival after surgery reached 44 months in 1 patient (59 months after diagnosis). Outcome was better in patients who had surgery after recurrence rather than after nonresponse to chemoradiotherapy. Salvage esophagectomy can be beneficial, in selected patients, after unsuccessful chemoradiotherapy for cancer of the esophagus by providing longer survival and better quality of life despite operative and postoperative morbidity.

Adult↗
PubMed1987

Recovery of normobaric hypoxia-lowered skin conductance response (SCR) in mice: SCR-hypoxia test, an animal model for testing drugs against brain hypoxia.

SCR-hypoxia test is based on the possible recovery by treatments tested of the SCR depressed through hypoxia. All drugs were administered intraperitoneally to male and female Swiss Orl mice randomized into groups of 10. SCR is measured with a palmar skin conductance-meter, in response to a photostimulus. This apparatus takes place in a cell allowing working in a definite hypoxic atmosphere, at a normal pressure. 15 drugs clinically used in various pathological states related to hypoxia are tested. SCR magnitude is recovered by the "antihypoxic" drugs. Specificity, sensitivity and quantifying value of the test are discussed leading to propose the SCR-hypoxia test in the design of new potentially antihypoxic drugs.

Animals↗
PubMed1985

Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines.

Correlation between specific binding potencies "in vitro" of several benzodiazepines and activities in SCR-habituation test is very satisfactory. As the SCR-habituation test might be considered as an elementary model of anxiety state, the test is suggested to be used as an intermediate psychopharmacological tool before clinical study. SCR-magnitude test exhibits no correlation of this kind proving that sedative activity is of a different mechanism.

Animals↗