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J Rasch

Publications and source records attributed to J Rasch.

7 recordsLinked to original sources
PubMed2000

Investigation of annexin V binding to lymphocytes after extracorporeal photoimmunotherapy as an early marker of apoptosis.

BACKGROUND: Induction of programmed cell death is assumed to be a possible effect of extracorporeal photoimmunotherapy (ECPI). OBJECTIVE: In the present study lymphocytes of patients with cutaneous T cell lymphoma undergoing ECPI were investigated for early apoptotic events. METHODS: Annexin V, known for its selective affinity to phospholipids, was used to detect early phases of apoptosis. Simultaneous staining with propidium iodide binding to DNA allowed detection of late apoptotic/necrotic cells. RESULTS: At 1 h after ECPI, an increase in early apoptotic cells was found indicating a direct effect of ECPI. At 20 h after each ECPI session, a delayed increase in the number of apoptotic lymphocytes was observed in early apoptotic annexin-stained cells and in late apoptotic cells, whereas in nonirradiated cells no remarkable changes were found. Apoptosis was confirmed by altered light scattering properties and DNA fragmentation. CONCLUSION: The apoptotic cell death of reinfused lymphocytes is supposed to be a therapeutic effect of ECPI.

Aged↗
PubMed1983

An evaluation of coronary regulation by the 99mTc bolus technique.

A new non-invasive method for investigating total coronary blood supply is presented. This method is based on the principle of indicator dilution of a radio-nuclide bolus (99Tc), requiring a scintillation camera with high sensitivity and high picture resolution. The first findings obtained from 83 patients are shown. With 4.61 +/- 1.19% of cardiac output the mean values of the rates of coronary perfusion obtained at rest in subjects with a normal heart differed significantly from those obtained for patients with certain coronary occlusions (8.18 +/- 3.99% of cardiac output) and from those obtained for hypertensive patients (Stages I-III). Double examinations carried out on 20 patients yielded an adequate reproducibility. The mean deviation of the double examinations from one another was 16%.

Adult↗
PubMedDate not supplied

Correlates of life satisfaction: an aid analysis.

The Automatic Interaction Detector (AID3) was used to develop a model based on the interaction of predictors of life satisfaction. The sample consisted of 871 people over fifty-five years of age. Thirty-one potential predictors were used representing demographics, environmental variables, and social psychological variables. The findings indicate that nine predictors explained 22.1% of the variance in life satisfaction scores. The most important predictors of life satisfaction were family life satisfaction, personal health satisfaction, and satisfaction with dwelling. The interactions between the predictors indicated that a simple linear-monotonic relationship between the predictors was too restrictive.

Aged↗