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Biomedical subjects

J Rebhun

Publications and source records attributed to J Rebhun.

At least 19 recordsLinked to original sources
PubMed1991

Proteins of the complement system and acute phase reactants in sera of patients with spinal cord injury.

Complement activity was studied in patients with spinal cord transection. In some sera acute phase reactants: haptoglobin, C-reactive proteins, ceruloplasmin, as well as fibrinogen and fibrin degradation products, and immune complexes were monitored. Complement and acute phase reactants are increased in a majority of patients. Continuing inflammation and release of inflammatory mediators could be responsible for poor healing that commonly occurs in spinal cord injury. Urinary tract and other infections are associated with some but not all of the protein abnormalities. These proinflammatory proteins may contribute to the lack of healing of spinal transection.

Acute-Phase Proteins↗
PubMed1988

Association of asthma and freebase smoking.

Three patients addicted to cocaine in the form of "freebasing" were treated because of asthma. Patient no. 1 had very severe asthma while using the illicit drug. Patient no. 2's asthma became severe 2 months after she stopped this form of cocaine. Patient no. 3, who had asthma in childhood, developed cough and shortness of breath (but not wheezing) when he smoked the freebase but not while snorting. Freebasing may cause or contribute to asthma as a nonspecific irritant.

Adult↗
PubMed1988

A subglottic web in an asthmatic patient.

An atopic woman developed asthma that was not responsive to the usual antiasthmatic medications including steroids. The cardinal symptom was a stridor which in addition to dysphonia and unusual dyspnea led the author to suspect a thoracic inlet obstruction. The suspicion was confirmed by an esophagogram and diagnosis of a subglottic web was made by direct laryngoscopy.

Adult↗
PubMed1987

An attempt to prevent anaphylaxis by aerosolized antigen in guinea pigs.

In an attempt to provide an alternative and safer technique of specific hyposensitization for those patients for whom the conventional treatment presents a high risk for anaphylaxis, we used a guinea pig model for extracorporeal hyposensitization. We sensitized three groups of guinea pigs with an olive pollen extract. Two of the groups were sensitized before removal of their buffy coat and the third group was sensitized after the removal of their buffy coat. The buffy coat cells were incubated with the same antigen and intracardially reinjected into their respective donors. Subsequent challenges by aerosolized antigen and intracardiac injections were performed. We did a basophil degranulation on random samples of buffy coat of tested and control animals. We skin tested the animals and we examined the histopathology of their lungs. The animals reinjected with the incubated buffy coat prior to sensitization showed a greater protection from aerosolized antigen and the onset of their anaphylactic symptoms was significantly delayed when compared with controls. The results of basophil degranulation studies showed that animals sensitized before removal of their buffy coat had approximately a threefold increase of degranulated basophils as compared with animals that were sensitized after removal of buffy coat and approximately a fourfold increase when compared with controls. This degranulation did not affect the specific skin test. Histopathologic observations did not reveal any characteristics typical of anaphylaxis.

Aerosols↗
PubMed1983

Spinal cord injury: diagnostic indicators.

Two experiments are summarized. One study revealed the cutaneous reaction of patients with spinal cord injury to intradermal injection of histamine and compared it with the response of healthy controls. Results indicated that the prevailing number of patients with spinal cord injury failed to demonstrate the flare skin reaction below the lesion. In the second experiment the majority of patients with spinal cord injury showed an elevated complement level. Both findings could be helpful diagnostic procedures since the activated complement might play a potential role in the pathogenicity of this malady.

Complement Factor B↗
PubMed1983

Systemic lupus erythematosus activity and IgE.

Patients with active systemic lupus erythematosus (SLE) had a higher mean serum level of IgE than patients with SLE in remission. All five patients who had serum obtained during active disease had a drop in their total IgE levels when the disease process was quiescent. Further investigations are needed to settle the question of whether the elevated IgE found during active disease is primary or secondary, a pathogenic factor or an epiphenomenon.

Humans↗
PubMed1981

Extracorporeal hyposensitization.

Sensitized guinea pigs were reinjected with autologous cells of the buffy coat or T-cell enriched populations of lymphocytes following incubation with sensitizing antigen. The incubated cells of the buffy coat appeared to give the animal protection from severe signs and lesser manifestations of anaphylaxis.

Anaphylaxis↗
PubMed1980

Complement elevation in spinal cord injury.

Laboratory studies revealed an elevated complement in 66% of patients with spinal cord injury. It is postulated that the activated complement may be a component of self-feeding immunological mechanism responsible for the failure of regeneration of a mature mammalian spinal cord. There was no evidence that such an injury had any effect on pre-existing atopy.

Adolescent↗
PubMed1980

Histamine flare, a neurovascular response.

It has been shown that the histamine flare depends on the integrity of sympathetic innervation and of connecting pathways between the sympathetic nervous system and higher centers. This conclusion was reached on the basis of lack of skin responses to exogenous histamine in 75% of patients with spinal cord injury in this study.

Adolescent↗
PubMed1979

Skin response to histamine in systemic lupus erythematosus.

A comparative study of skin responses to histamine in systemic lupus erythematosus (SLE) patients and in a control group suggests that although there are individual differences in response, the SLE patients responded sooner to 1:100 dilution. Since the test did not result in any ill effect it is concluded that existing clinical methods of testing and treatment of SLE patients having allergies are safe from the viewpoint of the histamine effect.

Adult↗
PubMed1977

A new approach to the treatment of allergic nasopharyngitis.

Orally inhaled and nasally exhaled beclomethasone diproprionate (b.d.) under increased nasopharyngeal pressure was found beneficial in ameliorating symptoms of allergic nasopharyngitis. The most spectacular help was obtained by patients suffering from sinus headache. This treatment also was found to avert the flaring up of rhinitis, an occasional "unmasking" effect of orally inhaled b.d.

Adolescent↗