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Biomedical subjects

J Renault

Publications and source records attributed to J Renault.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Laryngeal paralysis after tracheal intubation for anesthesia].

A 17 year old man was anaesthetized for osteosynthesis of a fractured left femoral diaphysis. Endotracheal intubation was easy, anaesthesia and surgery were both uneventful. On recovery, some hoarseness was noticed. Two months later, an ENT examination showed signs of laryngeal paralysis. The presumed explanation was compression of the recurrent nerve by the high-positioned balloon of the tracheal tube. Recovery was complete four months later.

Adolescent↗
PubMed1983

Heterocyclic Quinones. 4. A new highly cytotoxic drug: 6,7-bis(1-aziridinyl)-5,8-quinazolinedione.

With the aim of obtaining new antitumoral agents, a series of 5,8-quinazolinediones was prepared. 5-Amino-6-methoxyquinazoline was oxidized by Fremy's salt to give 6-methoxy-5,8-quinazolinedione. Nucleophilic substitution reaction at C6, electrophilic substitution at C7, and synthesis of 7-amino-6-methoxy-5,8-quinazolinedione, the parent compound of streptonigrin, were studied. These compounds were tested for cytotoxic properties on L1210 leukemia cells in vitro. One of them, 6,7-bis(1-aziridinyl)-5,8-quinazolinedione, which exhibits a high cytotoxic activity (ID50 = 0.08 microM), was further screened in standard antitumor systems, including L1210 leukemia, P388 lymphocytic leukemia, sarcoma 180, and B16 melanocarcinoma. This drug gives a significant antitumoral effect on P388 leukemia but is inactive on other experimental models. Moreover, this compound was found to be highly mutagenic for Salmonella typhimurium TA98 and TA100 strains (Ames test), suggesting that DNA damage could be responsible for its cytotoxicity.

Animals↗