Discontinuing obsessive-compulsive disorder medication with behavior therapy.
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Biomedical subjects
Publications and source records attributed to J Ricciardi.
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Thirty-eight patients with primary obsessive-compulsive disorder participated in a 10-week, double-blind, placebo-controlled trial of the potent, selective serotonin reuptake inhibitor fluvoxamine. Fluvoxamine was significantly better than placebo on two of three measures of improvement in obsessive-compulsive symptoms. The authors also compared studies of the serotonergic agents fluvoxamine, sertraline, fluoxetine, and clomipramine and found that a greater effect size was associated with less serotonergic specificity and that some ability to affect other neurotransmitter systems may be a necessary but not sufficient requirement for antiobsessional activity. These data lend only partial support to a serotonin hypothesis of obsessive-compulsive disorder.
A 12-week open trial of fluoxetine in 61 obsessive-compulsive disorder patients significantly improved depressive and obsessive-compulsive symptoms. Baseline depression scores were not related to improvement on two obsessive-compulsive scales. The results reinforce the hypothesis of serotonergic abnormalities in obsessive-compulsive disorder.
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We prospectively determined the risk of initial stinger experience in a group of college football players while considering the presence of cervical canal stenosis and each player's position, playing time, and body type. Prospective analysis revealed a 7.7% incidence of initial stinger experience. The average Torg ratio for all players was 0.924 +/- 0.122, with the seventh cervical level being the narrowest. Initial stinger experience depended on position played and body type. The Torg ratio did not influence initial stinger occurrence. Players who experienced multiple stingers, however, had significantly smaller Torg ratios than players experiencing only one stinger (0.75 versus 0.87). A Torg ratio of 0.70 may be a more statistically and clinically appropriate threshold for determining significant cervical stenosis and advising collegiate athletes of their risk of experiencing recurrent stingers.