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Biomedical subjects

J Ringel

Publications and source records attributed to J Ringel.

At least 55 records · Page 3Linked to original sources

The clinical interpretation of electrocardiogram in hypertensive children and adolescents.

The validity and usefulness of the ECG criteria of left heart hypertrophy according to Sokolow and Lyon were tested in 54 hypertensive children and adolescents. Among them, there were 9 children with secondary hypertension of known origin, and 45 adolescents with labile juvenile hypertension due to hyperkinetic heart activity. Only in 21 (38%) patients were present positive ECG criteria of hypertrophy. In view of the fact that between 8 and 16 years of age the R and S voltage in left precordial leads in normal adolescents exceeds the voltage limits of these criteria in adults, the validity of criteria is discussed. It is postulated that the investigated criteria lose their validity in the given age group because of the age differences in the ECG patterns. An ECG diagnosis of cardiac hypertrophy can be made only when more than two positive criteria are present together with a clinical evidence of enlarged heart. If only one or two voltage criteria are present, it is advisable to interpret this as an ECG manifestation of left heart systolic overload and to use it only as auxiliary sign for further follow-up of the patient.

Adolescent↗

[Mannonidosis. Apropos of 5 cases].

Mannosidosis remains an extremely rare entity (9 published cases). Our personal experience, based upon 5 cases, suggests that the diagnosis may be based upon both positive as well as negative clinical and paraclinical data, which differentiate the disorder from other diseases which it resembles. The use of simple methods--thin layer chromatography of oligosaccharides and measurement of serum mannosidase at pH 3.5 and 4.5--render diagnosis easy. It should, however, be mentioned that there exists no valid treatment for this apparently autosomal recessive disorder but that ante-natal detection is theoretically possible.

Bone and Bones↗