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Biomedical subjects

J Rivest

Publications and source records attributed to J Rivest.

At least 19 recordsLinked to original sources

Prediction of methane production from dairy cows using existing mechanistic models and regression equations.

Ruminants may contribute to global warming through the release of methane gas by enteric fermentation. Until now, methane emissions from ruminants were estimated using simple regression equations. The objective of this study was to compare the capacity of dynamic and mechanistic models to that of regression equations to predict methane production from dairy cows. The updated version of the model of Baldwin et al. and a modified version of the model of Dijkstra et al. and the regression equations of Blaxter and Clapperton and Moe and Tyrrell were challenged with 32 experimental diets selected from 13 publications. The predictive capacity of mechanistic models and regression equations was evaluated by comparing predicted and observed methane production using regression analysis. Results of regression showed better prediction of methane production with mechanistic models than with regression equations. The modified model of Dijkstra et al. predicted methane production with the higher R2 (.71) and the smaller error of prediction (19.87% of the observed mean). The model of Baldwin et al. predicted methane production with a similar R2 (.70) but a higher error of prediction (36.93%). However, a large proportion of this error can be eliminated by a correction factor. Predictions using the equations of Moe and Tyrrell and Blaxter and Clapperton were poor (R2 = .42 and .57; error of prediction = 33.72% and 22.93%, respectively). This study demonstrated that from a large variation in diet composition, mechanistic models allow the prediction of methane production more accurately than simple regression equations.

Animal Feed

Perceptual learning of orientation discrimination by more than one attribute.

Using a perceptual learning paradigm, we evaluated whether information from the attributes: color, luminance and motion is combined to provide orientation coding. Four observers were trained to discriminate the orientation between color-defined bars, four between luminance-defined bars, and four between motion-defined bars. Before and after training, they were tested with each of the three attributes separately and all superimposed, at the same and at a different location as the one seen during training. A similar improvement was found whether the bars seen after training were defined by the same, or by a different attribute as the one seen during training, or by the three attributes superimposed. This improvement was significantly more substantial at the location where the bars were presented during training. Moreover, orientation discrimination was always better when the bars were defined by three attributes than by any one alone. Because the improvement was retinotopic and not restricted to the attribute seen during training, we suggest that training changed the sensitivity of orientation-selective cells responsive to color, luminance and motion. Moreover, the overall better performance with additional attributes supported an integration of information from color, luminance, and motion at a common site for orientation coding.

Analysis of Variance

Localizing contours defined by more than one attribute.

Two experiments were run in order to test how information from different attributes is combined to localize contours. In Expt 1 the apparent position of a contour defined by one attribute was measured while a contour defined by another attribute was presented beside it. Interactions were found between all pairings of luminance, color, motion and texture. These results suggested that the information associated with each contour is integrated at a common site. In Expt 2 the precision of localization was measured for contours defined by one, two or three attributes (combinations of luminance, color and texture). The improvement in precision with additional attributes again supported an integration of contour information at a common site prior to a decision of localization.

Color Perception

Botulinum toxin in the treatment of writer's cramp.

Forty-four patients with disabling writer's cramp (WC) and one with a musician's cramp were treated with botulinum toxin (BT) injections for a mean period of 12 (range, 3-48) months. The forearm muscles causing the dystonic position were identified by inspection while writing; BT was then administered under electromyographic (EMG) guidance. The degree of improvement in writing and amelioration of pain were rated with self-assessment scales. Patients reported significant improvement in writing after 56% treatment sessions (TS) and in pain after 62% TS. Mild weakness occurred after 32% TS. Twenty-nine patients discontinued treatment, generally after the initial BT injection. In 16 patients who remained on treatment with a mean follow-up of 21 (range, 3-48) months, the improvement in writing and pain was present after 76 and 79% of the TS, respectively. We conclude that BT injections offered a worthwhile and sustained functional improvement to 36% of our patients with WC.

Adult

The contribution of color to depth perceived from motion parallax.

Perceived depth was measured in a colored stimulus while stimulus movement yoked to head displacement simulated a depth of 1 cm. Velocity judgments were also made for similar stimuli moving at the same average speed but without head movement. Both measures decreased to a minimum of about 30-40% of the veridical values when the stimuli were equiluminous. Perceived depth and speed also decreased for a monochromatic stimulus as a function of luminance contrast but much more abruptly than for the chromatic stimuli. The results indicate that equiluminous color stimuli contribute to the perception of depth from motion parallax and that the contribution is not mediated by residual luminance.

Color Perception

Interhemispheric depth judgement.

Interhemispheric depth comparisons were studied by requiring subjects to align in depth two textured plates, one presented to the left hemifield and the other to the right. Callosal agenesis subjects and neurologically-normal control subjects adjusted the plates so that they appeared to be at the same distance. Subjects viewed the plates monocularly or binocularly while keeping their head still, moving it side-to-side or moving it up and down. Subjects fixated a target located between the two plates while performing the task. For all subjects, the results showed that the deviations from veridical settings were significantly smaller for the binocular than for the monocular viewing conditions. Moreover, there were no significant differences among the three binocular viewing conditions (horizontal, vertical or no head movement), indicating that neither vertical nor horizontal motion parallax improves the precision of depth judgement when binocular disparity is available. These results further suggest that the precision of interhemispheric comparison for binocular depth is not affected by the absence of the corpus callosum. Looking at the plates monocularly, the control subjects judge the relative depth between the plates more precisely when they moved their head than when they kept it still. These results show that motion parallax is a useful depth cue when relative motion is extracted from different hemifields. Unlike the control subjects, the callosal agenesis subjects did not judge the relative depth between the plates more precisely when they moved their head than when they kept it still. These results show that interhemispheric comparison of depth using relative motion is not possible without the corpus callosum.

Adult

Treatment of cervical dystonia hand spasms and laryngeal dystonia with botulinum toxin.

One hundred and twenty-six patients with different forms of focal dystonia (89 with cervical dystonia, 12 with hand cramps and 25 with laryngeal dystonia) were treated with localised injections of botulinum toxin. Mean doses per muscle were 200 mouse units (m.u.) for treating cervical dystonia, 40-120 m.u. for forearm muscles in writers' cramp and 3.7 m.u. for the thyroarytenoid muscle in laryngeal dystonia. Responder rates have been above 80% in all patient groups and beneficial effects could be reproduced over follow-up periods of up to 4 years. The commonest side-effects were dysphagia after treatment of spasmodic torticollis, weakness of neighbouring muscles after injections for hand cramps and breathiness and hypophonia following laryngeal injections. All these were transient and generally well tolerated. It is concluded that botulinum toxin injections are a safe and effective treatment in all three types of focal dystonia.

Botulinum Toxins

Botulinum toxin treatment of spasmodic torticollis.

We reviewed the efficacy and adverse effects of repeated botulinum toxin injections into hyperactive neck muscles of 107 successive patients with spasmodic torticollis. They received 510 injection treatments over a median period of 15 months (range 3-42 months). One patient failed to benefit at all, but 101 (95%) patients reported considerable (moderate or excellent) benefit from at least one treatment. On a global subjective response rating, 93% of 429 treatments resulted in some improvement and 76% in moderate or excellent improvement. Pain reduction followed 89% of 190 treatments with moderate or excellent reduction after 66%. Median duration of benefit was 9 weeks. All torticollis types responded equally well and injections into two (or more) involved neck muscles were more effective than injection into a single muscle. The most frequent adverse effect was dysphagia, occurring after 44% of all treatments, but this was severe after only 2%. Antibodies to botulinum toxin were detected in the serum of three out of the five patients in whom loss of treatment efficacy occurred. We conclude that botulinum toxin treatment is the most effective available therapy for spasmodic torticollis and practical advice is provided for anyone wishing to set up the technique.

Adult

Writer's cramp: treatment with botulinum toxin injections.

Twelve patients with writer's cramp were treated with injections of botulinum toxin. The overactive muscles were identified by clinical observation of the subjects while they were writing. Repeated injections were given at 2-week intervals until the optimal response was obtained. Eleven patients reported some benefit, which was considered by seven to be significant. Eight of the 10 patients who had pain reported moderate to significant relief. Five patients had local complications, consisting of disabling weakness of target or neighbouring muscles. These preliminary results suggest that this treatment can be successfully applied to many patients with writer's cramp without performing complex electromyographic recordings while the patients are writing.

Adult

Periodic lateralized epileptiform discharges with transitional rhythmic discharges: association with seizures.

Low amplitude rhythmic discharges (RDs) closely associated in time and in spatial distribution to inter-ictal epileptiform discharges are not seen in scalp EEGs of patients with non-periodic focal epileptiform discharges (NPEDs) but they are unexpectedly common in patients with periodic lateralized epileptiform discharges (PLEDs). A classification of PLEDs into PLEDs Proper (PLEDs without RDs), and PLEDs Plus (PLEDs with RDs) is proposed. Such a classification is useful for an easier appreciation of PLEDs' pleomorphism. It underscores the changing periodicity of PLEDs and allows for a more inclusive definition of the phenomenon than the one reported by the literature. It also emphasizes the importance of recognizing RDs in scalp EEGs as transitional anomalies intercalated between inter-ictal PLEDs and ictal seizure discharges, analogous to those observed by Ralston in animal models. Indeed, the occurrence of recorded seizures is higher in patients with PLEDs Plus than in those with PLEDs Proper or NPEDs.

Electroencephalography

Pharmacological modulation by cetirizine and ebastine of the cutaneous reactivity to histamine.

The peripheral H1-inhibiting effects of cetirizine 10 mg and ebastine 10 mg were compared at the skin level after single oral administration. The study was performed in 9 healthy subjects under double-blind randomized crossover conditions. Both drugs were significantly effective up to 24 h. The suppressive effect of cetirizine was significantly more rapid and more marked.

Administration, Cutaneous

Trunk and head tremor as isolated manifestations of dystonia.

Five patients presenting with isolated tremors of the trunk or neck are described. Their clinical features were similar to seven other patients who presented with head tremor, or arm and head tremor, but then eventually developed obvious torticollis, sometimes with arm dystonia. We conclude that isolated tremor of the trunk or head, especially of slow frequency (2-5 Hz), and in the case of the head in a "no-no" direction, may be the initial manifestation of focal dystonia.

Adult

Dystonia in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.

Adult-onset dystonia-parkinsonism is a syndrome in search of a pathology. We therefore reviewed the literature on dystonic manifestations in autopsy-proven cases of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and idiopathic Parkinson's disease (PD). Only 6 of 140 autopsy reports of MSA remarked on the presence of dystonia in life, but personal observations suggest prominent antecollis may develop at some stage in up to 1/2 of sufferers. Similarly, very few (15/118) clinicopathologic observations on PSP included convincing dystonic manifestations, in contrast to some clinical reports where blepharospasm and early limb dystonia were prominent. Virtually any form of focal and segmental dystonia may sometimes occur with clinically diagnosed PD, with occasional descriptions of hemidystonia-hemiparkinsonism. However, there is pathologic confirmation of this diagnosis in only 1 case. With many patients thought clinically to have PD proving pathologically to have another cause for their parkinsonism, the true frequency and the range of dystonic manifestations acceptable in PD remain unknown.

Brain Diseases

Transient anosognosia for episodic hemiparesis: a singular manifestation of TIAs and epileptic seizures.

Anosognosia is a well-known manifestation of non-dominant parietal lobe lesions and typically lasts a few days. That anosognosia may last only a few minutes to a few hours, as observed in six patients, has not been reported. In five patients, transient anosognosia for equally brief left-sided hemiparesis was a manifestation of transient ischemic attacks (TIAs). In the sixth patient, anosognosia for both a left-sided motor seizure and a subsequent brief left hemiparesis could best be explained by an epileptic ictal and post-ictal transient dysfunction of the non-dominant parietotemporal cortex. Prompt recognition of transient anosognosia, whether ischemic or epileptic, is mandatory for proper diagnosis and for rapid initiation of specific therapy.

Aged

The roles of convergence and apparent distance in depth constancy with motion parallax.

The question of whether motion parallax is calibrated by convergence or by apparent distance for depth perception was addressed in three experiments. In Experiment 1, a random dot parallactic display was viewed monocularly at a distance of 80 cm, and the convergence angles were set for distances of 40, 60, and 80 cm. Averaged apparent depth was not different across conditions. In Experiment 2, a display consisting of one surface showing dollar bills and one surface showing random dots was viewed monocularly at a distance of 80 cm. It was presented at two different apparent distances, which were manipulated by varying the size of the dollar bills. In one condition, normally sized dollar bills were presented, and in another condition, the size was reduced by 30%. The averaged apparent depth associated with the small-bill display was larger than the depth associated with the normally sized bill display. In Experiment 3, a random dot display was viewed monocularly at 120 cm. In the primary condition, the random dot display was viewed with an induction screen at 80 cm, and it was moved from side to side such that it appeared stationary and close to the plane of the induction screen. In a comparison condition, the display was viewed without the induction screen and was moving from side to side at 120 cm. In another comparison condition, the display was again viewed without the induction screen but was stationary at 120 cm. Observers adjusted the extent of motion parallax so that apparent depth was 1 cm. The mean extent of parallax was larger in the primary conditio.(ABSTRACT TRUNCATED AT 250 WORDS)

Accommodation, Ocular

Depth perception as a function of motion parallax and absolute-distance information.

The results of three experiments demonstrated that the visual system calibrates motion parallax according to absolute-distance information in processing depth. The parallax was created by yoking the relative movement of random dots displayed on a cathode-ray tube to the movements of the head. In Experiment 1, at viewing distances of 40 cm and 80 cm, observers reported the apparent depth produced by motion parallax equivalent to a binocular disparity of 0.47 degree. The mean apparent depth at 80 cm was 2.6 times larger than at 40 cm. In Experiment 2, again at viewing distances of 40 cm and 80 cm, observers adjusted the extent of parallax so that the apparent depth was 7.0 cm. The mean extent of parallax at 80 cm was 31% of that at 40 cm. In Experiment 3, distances ranged from 40 cm to 320 cm, and a wide range of parallax was used. As distance and parallax increased, the perception of a rigid three-dimensional surface was accompanied by rocking motion; perception of depth was replaced by perception of motion in some trials at 320 cm. Moreover, the mean apparent depths were proportional to the viewing distance at 40 cm and 80 cm but not at 160 cm and 320 cm.

Cues