PubMed Health⌕ Search

Biomedical subjects

J Rodgers

Publications and source records attributed to J Rodgers.

At least 55 records · Page 3Linked to original sources
PubMed1996

Cost of administering controlled drugs in a hospice ward.

A study was undertaken in 1995 to examine the time taken to administer Controlled Drugs (CDs) in one of the two seven-bedded wards in the Prince and Princess of Wales Hospice (PPWH) in the course of one week. A stop watch was used to measure the time taken from the decision to give a CD until its administration was entered into the CD Register. The drugs used were oral morphine, oral sustained release morphine and diamorphine for subcutaneous administration by syringe driver. The grade of nurses involved in administering the CDs was also recorded. The time taken by D, E, F, and G grade nurses was extrapolated to the number of hours per annum spent administering the CDs. The hourly rate for the various grades was documented and the total cost calculated. The total annual cost of administering CDs to the seven patients in the study was calculated to be 10,883.94 pounds. The total cost for the two wards was extrapolated to 21,767.88 pounds. The annual cost of the CDs was 7,294.63 pounds. The total cost of the CDs and their administration was 29,062.51 pounds: 75% of the expenditure is the cost of administration. Syringe drivers cost twice as much to administer as sustained release morphine tablets.

Analgesics, Opioid↗
PubMed1996

Atomic force microscopy investigation of radiation-induced DNA double strand breaks.

We have used atomic force microscopy (AFM) to study radiation-induced DNA double strand breaks. Double-stranded plasmid DNA was irradiated with 18-MeV electrons in aqueous buffer, using a medical linear accelerator. Doses of 50, 100, 150, and 200 Gy were delivered to DNA samples, and atomic force microscopy was used to measure the length of each DNA fragment. From these measurements, we obtained the average length of the irradiated DNA for each sample and found a linear-quadratic relationship between the average length and radiation dose.

DNA↗
PubMed1995

Do shifts toward service industries, part-time work, and self-employment explain the rising uninsured rate?

It is conventional wisdom that the increase in the number of uninsured people during the 1980s was due, in part, to systematic trends in employment, specifically: 1) shifts from full-time to part-time jobs and to self-employment; and 2) changes in the industrial mix of employment, especially toward the service industries. This paper uses the March Current Population Survey data from 1980 through 1987 to measure the contribution of these factors to the rise in the uninsured. In the first case, we find the premise of rising part-time work and self-employment to be untrue. In the second case, less than 15% of the decline in health insurance over this period was due to employment shifting from higher-coverage to lower-coverage industries. Instead, the decline resulted from falling coverage rates across all industries. This is not to dismiss the possible importance of such employment trends over decades, but to emphasize the need to investigate other causes of the change during recent years.

Data Collection↗
PubMed1994

Role of serological tests in the diagnosis of immune complex disease in infection of ventriculoatrial shunts for hydrocephalus.

Seven cases of ventriculoatrial shunt infection with immune complex disease are reported in order to demonstrate the usefulness of measurement of levels of specific antibody to Staphylococcus epidermidis in diagnosis. Blood and cerebrospinal fluid cultures gave misleading results, and there was initial doubt about the diagnosis in all seven cases. All showed grossly elevated titres of antibody to Staphylococcus epidermidis, with raised serum C-reactive protein levels and depressed complement levels. Measurement of antibody to Staphylococcus epidermidis enables the diagnosis of chronic ventriculoatrial shunt infection to be made rapidly and reliably.

Adolescent↗
PubMed1994

The effects of extracellular slime from Staphylococcus epidermidis on phagocytic ingestion and killing.

Extracellular slime (Ecs) from three strains of Staphylococcus epidermidis was prepared and added to fresh suspensions of polymorphonuclear neutrophils. Phagocytic ingestion and killing of opsonised and unopsonised S. epidermidis strains was assessed over time using slide preparations stained by the Gram's method and microbiological culture. Both phagocytic ingestion and killing were inhibited. Investigation as to one possible mechanism of action of Ecs on phagocytes was performed using 1 mu polystyrene spheres which were incubated overnight with Ecs. It was found that the surface tension was altered with Ecs making the beads more hydrophilic, a factor which may interfere with the phagocytic response to infection.

Bacterial Proteins↗
PubMed1993

Serological response to coagulase-negative staphylococci in patients with peritonitis on continuous ambulatory peritoneal dialysis.

Sera and dialysis effluent from 20 patients on continuous ambulatory peritoneal dialysis (CAPD) with coagulase-negative staphylococcal (CNS) peritonitis were examined by immunoblotting for antibody activity against CNS. Immunoblotting was highly sensitive and demonstrated significantly greater antibody activity in serum and dialysate of infected patients compared with that of uninfected CAPD patients or healthy volunteers. Fourteen of 20 infected CAPD patients had strong antibody activity (> 7 bands); one patient had equivocal activity. Five patients had weak antibody activity, two of whom suffered from recurrent peritonitis with distinguishable CNS strains despite a satisfactory CAPD technique. One patient with a poor CAPD technique had strong antibody activity, but suffered from recurrent peritonitis. Examination of sequential sera suggested that seroconversion occurred soon after insertion of the Tenckhoff catheter, possibly in the absence of clinical infection. Antibody activity against a 25 kDa staphylococcal protein was significantly associated with peritonitis.

Antibodies, Bacterial↗
PubMed1992

Dietary supplementation with fish oil in ulcerative colitis.

OBJECTIVE: To determine the efficacy of fish oil supplementation in patients with active ulcerative colitis. DESIGN: Multicenter, randomized, double-blind, placebo-controlled, crossover trail with 4-month treatment periods (fish oil and placebo) separated by a 1-month washout. SETTING: Four gastroenterology divisions. PATIENTS: Twenty-four patients with active ulcerative colitis entered the study. Five dropped out, and one was noncompliant. Eighteen patients completed the study. All patients had active disease as manifested by diarrhea and rectal inflammation. INTERVENTIONS: Treatment with prednisone and sulfasalazine was continued. Fish oil supplementation consisted of 18 Max-EPA (eicosapentaenoic acid) capsules daily (eicosapentaenoic acid, 3.24 g; and docosahexaenoic acid, 2.16 g). Placebo supplementation consisted of 18 identical capsules containing isocaloric amounts of vegetable oil. MEASUREMENTS: Patients were evaluated at study entry and after each diet period. Evaluations included a review of symptoms, flexible sigmoidoscopy, rectal biopsy, and rectal dialysis to measure prostaglandin E2 and leukotriene B4 levels. RESULTS: Fish oil supplementation resulted in a significant decrease in rectal dialysate levels of leukotriene B4 from 71.0 to 27.7 pg/mL (average change, -43.3 pg/mL; 95% CI, -83 to -3.6). Significant improvements were seen in acute histology index (average change, -8.5 units from a baseline of 10.5 units; CI, -12.9 to -4.2) and total histology index (average change, -8.5 units from a baseline of 14.80; CI, -13.2 to -3.8) as well as significant weight gain (average weight gain, 1.74 kg, CI, 0.94 to 2.54). No significant changes occurred in any variable during the placebo period. Seven patients received concurrent treatment with prednisone. During the fish oil supplementation period, the mean prednisone dose decreased from 12.9 mg/d to 6.1 mg/d and rose from 10.4 mg/d to 12.9 mg/d during the placebo diet period (P greater than 0.20). CONCLUSIONS: Four months of diet supplementation with fish oil in patients with inflammatory bowel disease resulted in reductions in rectal dialysate leukotriene B4 levels, improvements in histologic findings, and weight gain.

Adult↗
PubMed1992

Radiotherapy of malignant subdiaphragmatic implants in advanced ovarian carcinoma: a new technique.

We report the development of a new technique using remote afterloading intraoperative radiation therapy to deliver a tumoricidal dose to diaphragmatic tumor implants. A multi-positional lucite applicator was designed based on anatomic studies of the diaphragmatic surface to accommodate a high dose rate iridium source in a series of needles placed 1.5 cm apart. The applicator curvature can vary from planar to full accommodation of the diaphragmatic surface with a constant source to surface distance of 0.5 cm. The applicator has been piloted in three patients with ovarian carcinoma with residual subdiaphragmatic disease found at second look laparotomy, to deliver a dose of 1,500 to 2,000 cGy at 0.5 cm. Tolerance of the diaphragm and hepatic surface has been excellent. There were no postoperative complications and no deterioration in liver function studies. The additional postoperative external beam irradiation directed with the aid of surgically placed clips and gated to respiratory movements permits achievement of a tumoricidal dose while limiting the treated volume and related toxicities.

Brachytherapy↗
PubMed1992

Memory after treatment for acute lymphoblastic leukaemia.

Long term survivors of acute lymphoblastic leukaemia (ALL) often experience cognitive difficulties, which may be related to impairment of memory function. Memory ability has been studied in a group of survivors of ALL along with sibling controls and in children who have received treatment for other forms of cancer. Children in the ALL group were found to have significant deficits in memory function in tasks which required the application of strategic planning behaviour. These deficits are potentially remediable by educational strategies.

Adolescent↗
PubMed1991

Cognitive function after two doses of cranial irradiation for acute lymphoblastic leukaemia.

The cognitive function of 23 children given cranial irradiation in a dose of 24 Gy was compared with that of 41 given 18 Gy. No significant differences were found in intellectual function or in mean number of intelligence quotient points lost between patients in the two treatment groups. A reduction in the dose of cranial irradiation does not seem to alleviate long term neuropsychological deficits.

Child, Preschool↗