PubMed Health⌕ Search

Biomedical subjects

J Rollet

Publications and source records attributed to J Rollet.

At least 19 recordsLinked to original sources
PubMed1989

HLA antigens and infertility with sperm autoantibodies in man.

Vasectomized men with sperm auto-antibodies (S.A.A.) and high frequency of HLA-A20 antigen (Ag) were observed by Law et al. (1979); Hancock et al. (1983) observed the prevalence of HLA-A28 in infertile men with S.A.A. HLA-A, B and DR Ag were determined in a population of 80 Caucasian infertile men with (n = 22) or without (n = 58) agglutinating and/or cytotoxic S.A.A. in serum (S) and/or seminal plasma (SP), and the association between HLA-determinants and infertility with S.A.A. was investigated. The frequence of HLA-A28 Ag was found higher in the group with S.A.A. than without (18.2% vs 0.0%) but not statistically significant (chi 2 = 8.87; pc less than 0.15). The same result was obtained with HLA-B13 Ag (chi 2 = 8.87; pc less than 0.32). Lastly, there was no prevalence of HLA-DR Ag in men with S.A.A. In conclusion, no association was found between HLA-A, B and DR Ag and infertility with S.A.A. Nevertheless, two HLA-Ag were more frequently observed in the group with S.A.A.

Adult↗
PubMed1989

[Etiologic evaluation of oligo-astheno-teratospermia].

The numerous etiological factors of male hypofertilities and the lack of precision relating to physiopathological mechanisms explain the weak therapeutic armamentarium. It is therefore absolutely necessary to perform a clinical, biological and paraclinical evaluation, logical and standardized, in order to determine etiology which can be cured and attempt a prognosis. The interview, the clinical examination and the sperm count represent the basis from which additional explorations (hormonal assays, biochemistry of the semen, immunological work-up, caryotype, paraclinical examinations) may be requested and provide more specific data.

Antibodies↗
PubMed1988

Inhibition of spermatogenesis in men using various combinations of oral progestagens and percutaneous or oral androgens.

Eight men (experiment 1) requesting male contraception received a daily oral dose of 20 mg medroxyprogesterone acetate (MPA) combined with 125 mg percutaneous dihydrotestosterone (DHT). Three months later the mean sperm count was only diminished slightly; the replacement of DHT for four men by percutaneous testosterone at the same concentration led to a dramatic fall in sperm count. For 6-18 months all men were treated with MPA plus percutaneous testosterone (250 mg daily). The latter dose restored physiological levels of plasma testosterone. Follicle-stimulating hormone levels were inhibited more severely than in the DHT-treated group, whereas LH levels were variable. Azoospermia was achieved and maintained in six cases; two men were oligozoospermic and in one case a moderate secondary rise in the sperm count was observed. Twelve volunteers (experiment 2) received a daily oral dose of either 5 or 10 mg norethisterone acetate plus percutaneous testosterone (250 mg daily). All of them achieved azoospermia within 2 months, but two subjects later exhibited a partial restoration in sperm count. Follicle-stimulating hormone and LH levels were inhibited more severely than in the first experiment. The sperm count and gonadotrophin levels returned to initial values within 6 months after cessation of the treatment in both experiments. No side-effects were noted concerning blood parameters, libido or body weight. However, several female partners had elevated levels of plasma testosterone. In experiment 3 (13 volunteers), percutaneous testosterone was replaced by oral testosterone undecanoate (160 mg daily). Only seven men were azoospermic and most of them had lowered levels of plasma testosterone. Thus, the combination of percutaneous testosterone and oral progestagens appears to be the most convenient for male hormonal contraception.

Administration, Cutaneous↗
PubMed1987

[Silastic spermatocele].

The study was carried out in two stages. An initial experimental study in the rat showed that it was possible to attach a spermatocele to the rat epididymus and to collect spermatozoa during the months that followed. The clinical trial involved the implantation of 8 spermatoceles in 5 male patients. The technic is simple, as predicted by the animal study but, as previously described by numerous other authors, the communication between epididymus and spermatocele is obliterated within several months. These findings confirm the possibility of use of a spermatocele that is well tolerated and of simple functioning, but which does not allow fertile spermatozoa capable of producing pregnancy to be obtained.

Adult↗
PubMed1982

[Deferentography under local anaesthesia in male sterility : technique and results (author's transl)].

Deferentography was employed during medical and surgical investigations of 44 cases of male sterility. This technique is easily performed in out patients and appears to be inocuous. Radiological signs were normal in 31 cases, and it was possible to evaluate anatomical characteristics and to obtain precise measurements of the vasa deferentia, the ampulla, the seminal vesicles, and the ejaculatory canals. Abnormal findings, present in 13 cases, corresponded to bilateral deferens obstruction of either congenital (agenesis), or acquired (stenosis due to infection or inflammation) origin. The major limitation of this investigational method is that epididymal obstruction cannot be demonstrated.

Anesthesia, Local↗