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J Rosenblüh

Publications and source records attributed to J Rosenblüh.

4 recordsLinked to original sources
PubMed1997

[Ergometry separates sleep apnea syndrome from obesity-hypoventilation after therapy positive pressure ventilation therapy].

In contrast to the obstructive sleep apnoea syndrome (OSA) the obesity-hypoventilation syndrome (OHS) is characterized by persistent hypercapnia during the day. After positive pressure ventilation (PPV) patients with OHS the daytime blood gases normalize after a short time. The aim of this study was to investigate whether blood gases at the end of a standardized exercise test separate both OSA and OHS after 3 months of PPV. Fourteen patients with OHS (12 males, 53.2 +/- 9.5 years, BMI: 41.7 +/- 9.6 kg/m2, PCO2: 50.7 +/- 4.5 mmHg) and 28 patients with severe OSA (27 males, 54.5 +/- 8.3 years, BMI: 35.7 +/- 4.9 kg/m2, PCO2: 37.3 +/- 3.3 mmHg) were studied. Blood gases before and after 4 minutes constant load exercise test were measured. The exercise level for patients with OSA was 2/3 of the predicted maximal work load. Since in OHS the load tolerance was compromised, the exercise test was performed at 2/3 of the maximal exercise level which was investigated before. The identical exercise load was done before and 3 months after beginning the PPV. Compared to the OSA-group the load tolerance of the OHS-group was lower (112 +/- 20 Watt [2/3 of predicted maximal work load] versus 81 +/- 26 Watt [39.9 +/- 8.3% of predicted maximal work load], p < 0.0001). Both before and after 3 months of PPV all patients with OHS showed an exercise induced increase of PCO2 (Before PPV: from 50.7 +/- 4.5 to 56.6 +/- 5.8 mmHg; after PPV: from 39.1 +/- 2.7 to 45.6 +/- 2 mmHg, each p < 0.0001). Correspondingly the PCO2 decreased significantly. In OSA neither before nor after 3 months PPV the blood gases changed significantly during the exercise test. We conclude that the OHS associated hypercapnia during exercise is further on a reliable indicator for the diagnosis despite the daytime normocapnia during rest after PPV. However after PPV the PCO2-values of patients with OHS at rest are in the normal range.

Airway Obstruction↗
PubMed1995

[Increase in hypercapnia in exercise--an unloading strategy?].

BACKGROUND: Chronic hypercapnia seems to preserve the overloaded respiratory pump from manifest muscle failure. In order to get information about the regulation of the ventilation under exercise we investigated clinical stable hypercapnic patients. PATIENTS AND METHODS: Twenty-one patients (20 males, 53.7 +/- 13.2 years) with obesity-hypoventilation syndrome (8), chronic obstructive lung disease (4), scoliosis (3), myopathy (2) and post-Tbc (2) were examined. Ventilation parameters (fb, Vt, VO2), respiratory muscle strength (PImax, PEmax), arterial blood gases (pO2, pCO2), respiratory quotient (RQ) and lactate were measured at rest and at the end of 5 minutes of maximal bicycle exercise. The control group consisted of 10 healthy persons. RESULTS AND CONCLUSIONS: A significant augmentation of the pre-existing hypercapnia under exercise (reflecting hypoventilation in relation to the predicted value) was observed in all patients with chronically overloaded respiratory muscles. This mechanism seems to be wise because it protects the respiratory pump from failure.

Adult↗
PubMed1993

[Evaluation of a portable device for measuring maximal inspiratory pressure (Pimax)].

Pimax measurement is useful for quantifying the fatigue of the respiratory muscles (the "respiratory pump" of the mechanics of respiration), for controlling the therapeutic effect of artificial respiration performed at home, and assessment of the possibility of relieving a patient from artificial respiration. So far, such measurement had required complicated set-ups. A portable alternative is now available for Pimax measurement (MPM, distributed by Medanz, Starnberg, Germany). In a prospective study we compared the Pimax values measured via the mouth pressure measuring instrument under test, with the standard laboratory method. Statistical comparison of the measured data yielded a high degree of correlation (r = 0.97) with slight scatter of the individual data around the identity line. The portable instrument tested in this manner thus represents a mobile method yielding reliable Pimax values both on an inpatient and an outpatient basis.

Adult↗