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J Rosendahl

Publications and source records attributed to J Rosendahl.

6 recordsLinked to original sources

Doping, drugs and drug abuse among adolescents in the State of Thuringia (Germany): prevalence, knowledge and attitudes.

Goal-directed measures to prevent doping and drug abuse in sports requires empirical data. In this connection, a cross-sectional analysis was carried out in 2004. The purpose of the study, on the one hand, was to register reliable data of the current situation in Thuringia, and, on the other hand it was to give information on possible interventional steps with scientific support. Within three months, 2319 adolescents from 16 Thuringian schools (5 regular schools, 4 secondary schools, 3 sport schools and 4 vocational schools) were surveyed. Three hundred and forty-six (15.1 %) students out of 2287 students (26 students without a statement) indicated use of prohibited substances from the WADA list in the previous year: 16 (0.7 %) anabolic-androgenic steroids (AAS), 10 (0.4 %) growth hormones, 56 (2.4 %) stimulants, 305 (13.2 %) cannabis, 2 (0.1 %) diuretics, 52 (2.2 %) cocaine/heroin and 6 (0.3 %) erythropoeitin. Moreover, nonathletes (N = 490) reported a substance use that was approximately 5.0 % higher than that of recreational athletes (N = 1254) and nearly three times higher than that of competitive athletes (497). All three groups (nonathletes, recreational athletes and competitive athletes) performed poorly on a knowledge test regarding doping in general with an average below 60 % in each case. Another main aspect of the study was to determine factors influencing substance use in sports. Besides the doping specific knowledge (beta = 0.06, p < 0.05), age contributed (beta = 0.09, p < 0.05), as well as anti-doping attitude (beta = -0.34, p < 0.05), to the resulting variance. Gender, however, played no role. The findings of the study point towards the need for improvement of specific knowledge of doping among students and that their attitude towards doping must be altered. The goal in this case is to test the effectiveness of appropriate scientific intervention.

Adolescent↗

Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases.

BACKGROUND: Xenobiotic mediated cellular injury is thought to play a major role in the pathogenesis of pancreatic diseases. Genetic variations that reduce the expression or activity of detoxifying phase II biotransformation enzymes such as the UDP-glucuronosyltransferases might be important in this respect. Recently, a UGT1A7 low detoxification activity allele, UGT1A7*3, has been linked to pancreatic cancer and alcoholic chronic pancreatitis. OBJECTIVE: To investigate whether UGT1A7 polymorphisms contribute to the risk of pancreatitis and pancreatic cancer. METHODS: Genetic polymorphisms in the UGT1A7 gene were assessed in a large cohort of patients with different types of pancreatitis and pancreatic cancer originating from the Czech Republic (n = 93), Germany (n = 638), Netherlands (n = 136), and Switzerland (n = 106), and in healthy (n = 1409) and alcoholic (n = 123) controls from the same populations. Polymorphisms were determined by melting curve analysis using fluorescence resonance energy transfer probes. In addition, 229 Dutch subjects were analysed by restriction fragment length polymorphism. RESULTS: The frequencies of UGT1A7 genotypes did not differ between patients with acute or chronic pancreatitis or pancreatic adenocarcinoma and alcoholic and healthy controls. CONCLUSIONS: The data suggest that, in contrast to earlier studies, UGT1A7 polymorphisms do not predispose patients to the development of pancreatic cancer and pancreatitis.

Adenocarcinoma↗