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Biomedical subjects

J Rotteveel

Publications and source records attributed to J Rotteveel.

13 recordsLinked to original sources
PubMed2003

Growth during early childhood in asthmatic children: relation to inhalation steroid dose and clinical severity score.

BACKGROUND/AIM: While short-term studies reported a growth retardation in children with asthma treated with inhaled steroids, long-term studies described attainment of adult heights within the target height range. In the present work, we describe the growth pattern of children with asthma. METHODS: In 58 children with asthma, we compared the height at age 3 years with the height at a mean age of 7.5 years during a 12-month study period. RESULTS: No differences in growth could be detected within the study year. Children in the lowest tertile but not in other tertiles for asthma severity score and inhaled steroid dose showed a significant decrease in height standard deviation scores from age 3 to age 7.5 years. CONCLUSION: The decrease in height standard deviation scores might be explained by undertreatment or an individual sensitivity to inhaled steroids.

Administration, Inhalation↗
PubMed2001

Hormonal determinants of pubertal growth.

Pubertal growth results from increased sex steroid and growth hormone (GH) secretion. Estrogens appear to play an important role in the regulation of pubertal growth in both girls and boys. In girls, however, estrogens cannot be the only sex steroids responsible for pubertal growth, as exogenous estrogens do not initiate a complete growth spurt. We therefore investigated the levels of the different sex steroids and GH, and related them to pubertal growth. In addition, we studied the process of bone maturation and mineralization during this period. Levels of both estrogens and androgens were found to increase at the start of the female pubertal growth spurt, and it was demonstrated that height velocity is related to levels of GH, estradiol and androstenedione, but not dehydroepiandrosterone sulfate. In boys, GH, testosterone and estradiol increased at the time of peak height velocity. Bone mineralization increased as puberty began, and was associated with the increase in height velocity. Osteocalcin, a marker of bone formation, declined when height velocity decreased, although bone maturation progressed at a steady rate. We conclude, therefore, that in girls, the concerted actions of estradiol, GH and androstenedione play a role in the pubertal growth spurt, whereas in boys this role is fulfilled by testosterone, GH and estradiol. During puberty, an advanced rate of bone maturation with respect to cross-sectional standards is a physiological phenomenon.

Adolescent↗
PubMed2000

Ultrasonographic assessment of congestion of the choroid plexus in relation to carbon dioxide pressure.

Routine cerebral ultrasound examinations of the neonatal brain often show the choroid plexus to be enlarged, without revealing any other structural pathology. This enlargement might be due to congestion of the choroid plexus as a result of increased cerebral blood flow, due to increased partial pressure of carbon dioxide, amongst other factors. In this exploratory study, 76 cerebral ultrasound examinations, performed on 42 newborn infants within the first 10 days after birth, were analysed retrospectively. The ultrasonograms were classified into three diagnostic groups: normal, congestion of the choroid plexus and haemorrhage. The relationship between the diagnostic groups and the estimated mean arterial partial pressure of carbon dioxide (P(a)CO(2)) was investigated. In the first three postnatal days, the estimated mean P(a)CO(2) in the normal group was significantly lower than in the congestion group (P<0.001). No significant differences were found between the P(a)CO(2) in the congestion and the haemorrhage groups. The findings might support a relation between a high P(a)CO(2) and congestion of the choroid plexus in the first three postnatal days and might be a sign of increased risk for a periventricular haemorrhage.

Carbon Dioxide↗
PubMed2000

Amazing graces.

Explore the source record for details and available documents.

Adult↗
PubMed1998

Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.

Dihydropyrimidinase (DHP) deficiency (MIM 222748) is characterized by dihydropyrimidinuria and is associated with a variable clinical phenotype. This disease might be associated with a risk of 5-fluorouracil toxicity, although no cases have been reported. We present here both the molecular characterization of the human DHP gene and, for the first time, the mutations causing DHP deficiency. The human DHP gene spans >80 kb and consists of 10 exons. It has been assigned to 8q22, by FISH. We performed mutation analysis of genomic DNA in one symptomatic and five asymptomatic individuals presenting with dihydropyrimidinuria. We identified one frameshift mutation and five missense mutations. Two related Japanese adult subjects were homozygous for the Q334R substitution, whereas two other, unrelated Japanese infant subjects were heterozygous for the same mutation, but this mutation is not common in the Japanese population. A Caucasian pediatric patient exhibiting epileptic attacks, dysmorphic features, and severe developmental delay was homozygous for W360R. Using a eukaryotic expression system, we showed that all mutations reduced enzyme activity significantly, indicating that these are crucial DHP deficiency-causing mutations. There was no significant difference, in residual activity, between mutations observed in the symptomatic and those observed in the asymptomatic individuals.

Adult↗
PubMed1997

Serum procollagen I carboxyterminal propeptide (PICP) levels through puberty: relation to height velocity and serum hormone levels.

The synthesis of type I collagen, the major component of the organic bone matrix, is reflected by procollagen I carboxyterminal propeptide (PICP) levels. Conflicting reports have been made about the relationship between PICP levels and puberty. We have studied PICP levels in serum in relation to pubertal stage, height velocity, oestradiol, testosterone, androstenedione, dehydroepiandrosterone sulphate, insulin-like growth factor I and growth hormone levels in 32 healthy boys aged 7.2-15.8 years and 32 healthy girls aged 7.2-14.8 years. The PICP levels in girls tended to be higher during midpuberty: in boys the levels were higher at the end of puberty. The PICP levels correlated strongly with height velocity in boys and girls. In conclusion, PICP correlates especially with height velocity. The variation of PICP between subjects during puberty is considerable. The PICP levels may predict growth at a certain moment, especially in cases where only one height measurement is available.

Adolescent↗
PubMed1997

Androstenedione, dehydroepiandrosterone sulfate, and estradiol levels throughout female puberty: relation to height velocity.

Sex steroids are important contributors to the pubertal growth spurt. Both androgens and estrogens have been related to this moment of rapid growth, but the role of estrogens is thought to be the most important one. Since exogenous estrogens are not capable to induce an appropriate growth spurt in girls, there might be an additional contributing factor involved. In a recent pilot study of 32 healthy pubertal girls, we found that the peak height velocity (HV) is preceded by relatively high levels of dehydroepiandrosterone sulfate and androstenedione (delta4A) as compared with the end-pubertal level. In the present study we evaluated HV in relation to dehydroepiandrosterone sulfate and delta4A levels in 149 healthy girls of various Tanner stages. HV was correlated with delta4A and estradiol levels in Tanner stages I-III. These results suggest that, like estrogens, delta4A might be an important stimulator of the female growth spurt.

Adolescent↗
PubMed1995

Evoked potentials in children with chronic renal failure, treated conservatively or by continuous ambulatory peritoneal dialysis.

Children with chronic renal failure (CRF) show developmental, intellectual and motor disturbances. It is questionable if an early start of renal replacement therapy may prevent or delay these disturbances. We studied the neurological and intellectual development of children < 5 years suffering from CRF (creatinine clearance < 20% of normal) prospectively, over a period of 3 years. As part of the neurological study, brainstem auditory evoked potentials (BAEP) and somatosensory evoked potentials (SSEP) were recorded. Measurements were performed in a group of 22 children every 6 months. In 18 of these children CRF was present from birth. Sufficient data were available for analysis in 19 (BAEP) and 22 (SSEP), respectively. A delay of peak I of BAEP gave indications for peripheral conduction disturbances, possibly due to cochlear dysfunction. Brainstem conduction was normal. There were no differences between the children treated conservatively (n = 9) and those treated with continuous ambulatory peritoneal dialysis (CAPD) (n = 10). In children < 2.5 years SSEP showed a delayed thalamocortical conduction, which was not observed in older children. This might indicate a delayed myelination in young children with CRF. No differences were found between the children treated conservatively (n = 10) and those treated with CAPD (n = 12).

Child, Preschool↗
PubMed1995

Helping the helpers. A unique colleague support system for mental health professionals-consumers.

1. There are many professionals in the mental health workforce who have a mental illness themselves (prosumers), but who do not disclose that fact to their employers or colleagues for fear of stigma and discrimination. 2. Prosumers are in a particularly difficult situation; if they disclose, they risk being viewed as their illness, and if they do not disclose, they may not get the kinds of reasonable accommodations and support that would make their job more manageable. 3. Mutual support groups of colleagues are a viable and valuable way for prosumers to assist each other in coping with the stigma and stressors inherent in working in the mental health field.

Adult↗
PubMed1985

A neurophysiological study of children with the cerebro-hepato-renal syndrome of Zellweger.

The aim of this study was to describe the EEGs, brainstem auditory evoked potentials and somatosensory evoked potentials obtained in eleven children with the Zellweger syndrome. In six out of the eleven patients BAEPs and in five of them SSEPs were performed. Severe abnormalities could be demonstrated, reflecting diffuse cerebral dysfunction as well as long myelinated fiber tracts dysfunction. In four of six patients no response was obtained by BAEPs and in two the central conduction time was delayed. The specific (until 60 ms) and aspecific (after 60 ms) complex of the SSEPs was delayed or the potential could not be elicited. During sleep as well as wakefulness characteristic abnormalities of the EEGs were found in nine patients. These abnormalities consisted of continuous negative sharp waves and spikes at the vertex.

Brain↗