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J Rudnick

Publications and source records attributed to J Rudnick.

31 records · Page 2Linked to original sources
PubMed1991

Significance of the intracavernosal pharmacological injection test, pharmacocavernosography, artificial erection and cavernosometry in the diagnosis of venous leakage.

149 men suffering from erectile failure underwent a standardized combined procedure including intracavernosal pharmacological injection test (P test) artificial erection, pharmacocavernosography and cavernosometry with analysis of intracavernosal erection pressure and pressure drop. Patients with negative P test were considered to be suffering from 'venous leakage'; data of cavernosography and cavernosometry were analyzed in relation to the results of the P test. 99 men (66.4%) were P-test-negative. 98 of these patients (99%) had pathological cavernous drainage of the plexus santorinii during cavernosography. Flow rates for induction and maintenance of erection of the P-test-negative men were increased and intracavernosal erection pressure decreased significantly compared to the P-test-positive patients. The very diversified range of values made any individual statement impossible. In contrast to these findings, duration of pressure drop was significantly shorter among men with suspicion of venous leakage and without any overlapping compared to P-test-positive men. The findings provide evidence for the necessity, besides pharmacocavernosography, to include an estimation of intracavernosal pressure drop time in the diagnostic procedure of venous leakage in all men with confirmed negative P test.

Adult↗
PubMed1989

Intracavernous self-injection of prostaglandin E1 in the therapy of erectile dysfunction.

The efficacy of intracavernous autoinjection therapy with prostaglandin E1 was investigated over a period of up to six months in 187 patients with long-term erectile dysfunction. All patients had to undergo an investigation program consisting of routine laboratory tests, directional doppler sonography of the penile arteries, measurements of the BCR-latencies, as well as intracuvernum drug testing with PGE1. Six months follow-up results are available so far in 115 patients. The mean injection dose was 13.5 mcg PGE1 at the beginning of therapy and 12.8 mcg PGE1 at the end of therapy. An average of 24 prostaglandin E1 injections per patient was given. In 16.6% of the 187 patients slight to moderate pain occurred at the injection site, not influencing sexual intercourse. No priapisms lasting more than six hours were observed. A significant improvement of the blood flow in the deep and dorsal penile arteries was shown by penile doppler sonography after 6 months treatment. The efficacy and tolerability of the therapy were designated as very good to good in 91% respectively in 98% of the patients. 94% of the patients would like to continue the therapy. The results indicate that PGE1 due to its erectile potency and great tolerability will occupy an important position in the therapy of the erectile dysfunction.

Adult↗
PubMed1989

[Leakage correction by resection of the deep dorsal penis vein. Assessment of results after 4 years of venous potency surgery].

Resection of the deep dorsal vein is accepted as a short-term working procedure to reestablish erection in patients suffering from venous leakage. After 4 years with a standardized diagnostic and surgical program for pathologic venous drainage, we are now able to describe the outcome of vein resection in 51 men, whom we have treated 1-4 years before follow-up examination. After a median follow-up of 20 months, long-lasting full erection can be reported in 28 men. Of the remaining 23 men, reestablished erectile function decreased within 1 year in 8, while the operation failed in 15. Whereas the site of pathologic venous drainage and preoperative maintenance flow rates do not influence surgical outcome, a moderate arterial cofactor has become obvious in a large proportion of the unsuccessfully treated cases. In 14 of these men, papaverine testing has now become positive, so that penile self-injection of the drug makes adequate sexual intercourse possible. All patients with a postoperative negative papaverine reaction again have all the signs of a persistent pathological venous drainage; only in 2 of these cases has an ectopic vein been successfully resected.

Adult↗