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J Rueda

Publications and source records attributed to J Rueda.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Reversible damage to the nerve fibres in the organ of Corti after surgical opening of the cochlea in the rat.

After minimal opening of the cochlear bony wall, the efferent and the outer spiral fibres showed no changes; inner radial fibres (afferents to inner hair cells) were highly sensitive to this mild trauma, appearing swollen and empty of cytoplasmic content. Available data suggest that this may be due to alterations in the cochlear micromechanical environment, related to the surgical manipulation. The swellings were reversible, although the normal structure had not completely recovered until one month after the manipulation.

Animals↗
PubMedDate not supplied

Surgical trauma to the cochlea results in reversible damage to spiral ganglion type I neurons.

Type I neurons are reversibly damaged when the cochlear bony wall is opened. The reversibility is indicated by the absence of neuronal loss, as demonstrated by quantification of the spiral ganglion neuronal population. Reversible damages included ultrastructural signs of excessive ion and water influx into the type I neuron cytoplasm, whose functional implications must be investigated in the future.

Animals↗
PubMedDate not supplied

Distribution of glycoconjugates during cochlea development. A histochemical study.

Specific occurrence and distribution of glycoconjugates in the developing mouse cochlea was investigated using Alcian blue/PAS staining. The AB/PAS positive staining occurred intracellularly, extracellularly, pericellularly, and as glycocalyx. Pericellular staining occurred between certain epithelial cells in early stages of development, and extracellular deposit occurred mostly in mesenchymal tissue surrounding the cochlear duct and later in developing spiral ligament. During early stages of development, mesenchymal tissue and pericellular space of different epithelial cells of the cochlear duct were intensely stained, suggesting that these glycoconjugates may play an important role in the differentiation of the cochlear structures. Different supporting cells (e.g. Deiters' cells, pillar cells) were intensely stained at different development stages coinciding with the time when the subcomponents of the tectorial membrane (TM) were being formed. This finding suggests that glycoconjugates in the TM are produced by these cells.

Alcian Blue↗