Antibodies to phospholipid in alcoholic liver disease.
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Biomedical subjects
Publications and source records attributed to J Runcie.
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The suitability of four commercially available standing aids was assessed for routine therapy of a group of severely handicapped patients in hospital care. The problems which arose were mainly technical and these are considered. From experience gained during the study the design requirements of an ideal aid for these patients are proposed.
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Ten patients with severe neurological disease that was clinically indistinguishable from subacute combined degeneration of the spinal cord were found to have normal serum vitamin B12 levels. All were folate deficient. Specific folate treatment led to significant reversal of the neuropathy. These findings indicate the need to review orthodox concepts of the role of folic acid in maintaining the integrity of the nervous system.
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Daily weight loss measurements in 76 fasting, obese patients (58 females, 18 males) have shown a characteristic pattern of rapid loss initially (up to day 14) followed by a slower but uniform reduction in weight. There were significant sex differences. Measurements of tissue breakdown showed that the initial rapid weight loss was due to the continuing utilization by the nervous system of glucose derived from lean tissue. This requirement fell noticeably from the second week of starvation. Irreversible fluid elimination also contributed to the initial phase of rapid weight loss. Fat remained the primary source of energy throughout starvation and in established fasting (more than 14 days) contributed 96% of that requirement.
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Data are presented on the urinary excretion of sodium and potassium in 40 obese patients subjected to therapeutic starvation. Two patterns of sodium loss were observed: either a uniform low-level loss or a fluctuating loss leading in some cases to marked sodium depletion. In three patients the response was a combination of these two patterns.
Experience with 18 obese patients who have undergone prolonged (60 days) therapeutic starvation shows that in general this is a safe procedure, but there are significant associated hazards, particularly a breakdown in electrolyte homoeostasis. The need for close biochemical control of such patients is stressed.
A questionnaire was sent to 5,100 members of the Ileostomy Association of Great Britain and Ireland inviting the members to record their experiences in relation to the function of the ileostomy following on the ingestion of 29 named articles of diet. Nine hundred and fifty-two people, 623 females (65.4%) and 329 males (34.6%), completed the questionnaire satisfactorily. The group showed a close similarity to the total distribution found by the Association with regard to age, sex, and duration of ileostomy. Analysis of the data showed that the great majority of patients with an ileostomy have no difficulty in choosing a diet. The effects of various items of diet on functions of the ileostomy are analysed with special reference to the production of watery flow, upset of timing of filling of the bag, flatulence, pain, and odour. It is concluded that an individual patient with an ileostomy should not omit any article from his diet unless he has found that it repeatedly causes dyspepsia.
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