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Biomedical subjects

J Russ

Publications and source records attributed to J Russ.

9 recordsLinked to original sources
PubMed1988

Kinetics of peritoneal dialysis in children: role of lymphatics.

Intraperitoneal fluid is absorbed continuously by convective flow into the peritoneal cavity lymphatics. We evaluated the role of lymphatic absorption in the kinetics of peritoneal dialysis during standardized four hour exchanges in six children using 40 ml/kg of 2.5% dextrose dialysis solution. Cumulative lymphatic absorption averaged 10.4 +/- 1.6 ml/kg and reduced the total net transcapillary ultrafiltration during the dwell time by 73 +/- 10%. Due to the considerable lymphatic absorption rate, maximum intraperitoneal volume was observed before osmolar equilibrium. Extrapolated to four study exchanges per day, lymphatic absorption decreased the potential daily drain volumes in the children by 27 +/- 5% and daily peritoneal urea and creatinine clearances by 24 +/- 4% and 22 +/- 5%, respectively. Compared with four hour exchanges using two liters of 2.5% dextrose dialysis solution in 10 adult CAPD patients with average peritoneal transport, the children had more rapid equilibration of urea, greater absorption of dialysate glucose, higher lymphatic absorption and lower net ultrafiltration (P less than 0.01 to P less than 0.05). Lymphatic absorption therefore causes a relatively greater reduction in net ultrafiltration and solute clearances in children than in adults.

Adolescent↗
PubMed1988

[Effectiveness of bronchial lavage with a new double-lumen catheter].

The effectiveness of tracheobronchial lavage in the traditional manner with application of a rinsing solution into the endotracheal tube of artificially ventilated patients is unsatisfactory. In order to improve this a new double lumen catheter was developed. Beside the suction channel with a normal diameter is another very small channel, through which a rinsing solution or drugs can easily be applied endobronchially. The rinsing solution can be poured with high speed through this small channel into the peripheral bronchi. In comparison with the traditional method, endobronchial saline instillation and suctioning can be done more quickly during continuous artificial respiration. The tube was compared with a common suction catheter in 16 patients. These patients were intubated and given artificial respiration. Endobronchial rinsing and suctioning were done periodically. The suctioned bronchial secretion was measured and arterial blood gases were evaluated. Using the dual lumen probe, the suctioned volume was 3.8 times higher. In a short time the arterial oxygen pressure rose from 100% to 123%. An obvious improvement in ventilation could be seen even after 1 h. There was a positive correlation between the suctioned volume and the rise in oxygen pressure. Only suctioning of more than 3.7 ml was accompanied by a rise in the arterial oxygen pressure. Because of continuous artificial respiration, the arterial carbon dioxide pressure was kept constant. Therefore, there is a catheter available that makes it possible to perform a much more effective endobronchial lavage in a shorter period of time.

Aged↗
PubMed1986

To write "like a woman": transformations of identity in the work of Willa Cather.

Willa Cather's early life resembles one of the histories in Jonathan Katz's Gay American History. Her cross-dressing, invention of a male pseudonym, and details of behavior, together with her love for two women in her adulthood, Isabelle McClung and Edith Lewis, make it clear that Cather was a lesbian. Defensive about One of Ours, Cather nonetheless wrote much of her fiction in a male persona--A Lost Lady, The Professor's House, "Tom Outland's Story," Death Comes to the Archbishop, O Pioneers!, My Antonia, and One of Ours, as well as numerous short stories. Much of the fictional material in these works is curiously inconsistent with the male persona, but instead resembles lesbian experiences: the inaccessibility (to the narrator) of women who are nonetheless accessible to other men, absolute heartbreak at the untouchability of the women rather than anger or guilt or the search for sexual release elsewhere, and the women's intimacy with the men involved, as in One of Ours or O Pioneers!, without any suggestion of sexual involvement or explicit sexual history. Lesbian isolation, in adolescence at any rate, produces such situations; Carson McCullers's and some of May Sarton's work are cases in point. Speaking in masquerade, Cather is capable of describing lesbian experience with a fullness and unconsciousness which is now impossible. Innocence gave way to guilty self-consciousness, and that to politically conscious rebellion. The gain is in honesty, but Cather's record of lesbian experience, under whatever disguise, is nonetheless irreplaceable.

Famous Persons↗
PubMed1982

Aspartate carbamoyltransferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate.

Biopsy specimens were obtained from patients treated with N-(phosphonacetyl)-L-aspartate (PALA) in a phase I clinical trial. Activities of aspartate carbamoyltransferase (ACTase), the target enzyme, in ten specimens before treatment varied from 0.4 to 1.7 units/mg. PALA was measured in protein-free extracts of thirteen specimens by inhibition of rat ACTase. At 1.5 to 145 hr after doses of 1 to 6 g/m2, PALA concentrations were 0.9 to 89 micrograms/g; at 4 hr or later the tissue concentrations were similar to those in plasma (five samples). The observed inhibition of ACTase (17-87%) correlated with the PALA concentrations. Pyrimidine nucleotides were decreased (relative to purine nucleotides) in nine to ten specimens, by 16-72%. ACTase partially purified from human spleen had a Km for carbamoyl phosphate of 20.6 microM and the Ki for PALA was 0.011 microM. The results suggest that inhibition of ACTase by PALA affects the concentration of pyrimidine nucleotides in human tumors in a dose-dependent manner.

Antimetabolites, Antineoplastic↗
PubMed1979

Glycosylated hemoglobins and diabetes mellitus in pregnancy.

The glycosylated hemoglobins (HA1) were measured in the blood of normal nonpregnant (n = 50) and pregnant (n = 29) volunteers and pregnant diabetic patients (n = 21). HA1 in normal pregnancy (6.7% +/- 1.03%) did not differ significantly from values in nonpregnancy (7.5% +/- 0.73%) and did not vary with the stage of gestation. HA1 was increased in diabetic pregnancy (8.4+ +/- 2.15%) and was positively correlated with serial fasting blood sugar (FBS) mean values in samples drawn up to 16 weeks (r = 0.57) prior to the measurement of HA1, although the highest correlation (r = 0.73, p less than 0.001) was with FBS levels over the prior 8 weeks. A large standard error of the estimate (26.9 mg/100 ml) showed HA1 to be insensitive as an indicator of prior FBS. There was a large overlap of HA1 from known diabetic patients with the normal range for pregnancy. There was no correlation of third-trimester HA1 and newborn birth weight. It was concluded that (1) normal pregnancy does not alter HA1; (2) HA1 is proportional to prior mean FBS; (3) marked elevations of HA1 (greater than 10%) reliably predict poor diabetic control, but HA1 is not useful for fine control of FBS; (4) HA1 is not useful as a screen for diabetes mellitus; (5) HA1 is not predictive of newborn birth weight.

Birth Weight↗