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Biomedical subjects

J Rutsaert

Publications and source records attributed to J Rutsaert.

At least 19 recordsLinked to original sources

Argyrophilic breast carcinoma, single metastasis to the pituitary gland.

Five years ago, a 44 year-old woman presented with an apparently localized cancer of the right breast, initially treated by surgery, adjuvant chemotherapy and radiotherapy. After a 4 year disease-free interval, she developed bi-temporal hemianopsy, due to a suprasellar tumor causing compression of the optic chiasma. The tumor was resected by the transsphenoidal route and histological examination revealed neuroendocrine characteristics described as "argyrophilic breast carcinoma". The exceptional association of this peculiar histology for breast cancer with a rare pattern of recurrence (single pituitary metastasis) is worthwhile reporting.

Adult↗

[A case of (benign) teratoma of the nasopharynx].

The authors relate a case of a benign tumor (teratoma) sitting in the nasopharynx of a 10-year-old boy. A short review of the literature is presented: speculations over the origins of these tumors, possible diagnosis, treatments... The authors insist on the necessity of realizing some investigations (X-rays, fibro-endoscopy) when regarding a posterior nasal obstruction.

Child↗

[Infectious pulmonary and neurologic complications of Kaposi's sarcoma. Anatomo-clinical correlation with an ultrastructural study].

The authors report a case of generalised Kaposi sarcoma complicated by pulmonary cryptococcosis and cerebral toxoplasmosis. Clinical features were dominated by the cerebral condition. The infectious pathogenesis could be related to disturbances in immune defences. Ultrastructural study revealed the presence of several types of tumour cells. Endothelial cells formed vascular lumens and contained Weibel-Palade granules and reticulo-tubular inclusions.

Adult↗

The cellular lesions of Farber's disease and their experimental reproduction in tissue culture.

In a case of Farber's disease, lysosomal inclusions were shown to contain lamellar, rectilinear, or curvilinear material. In tissue culture, when fibroblasts from the patient were overloaded with ceramides containing nonhydroxylated fatty acids a lysosomal accumulation of small curvilinear structures identical with those observed at autopsy were seen. These inclusions persisted for several weeks after the cells were replaced in a normal culture medium. Normal fibroblasts overloaded in the same experimental conditions showed identical, although less numerous, lysosomal inclusions, which disappeared rapidly in a ceramide-free culture medium. No inclusions were found after overloading normal or pathologic fibroblasts with ceramides containing hydroxylated fatty acids.

Ceramides↗