Biomedical subjects

J S Abbas

Publications and source records attributed to J S Abbas.

6 recordsLinked to original sources

PubMed1988

Burn wound carcinoma: case report and review of the literature.

A 22-year-old man developed squamous cell carcinoma of the exophytic papillary type following a latent period of 14 years in a burn scar overlying the left forearm and wrist, with concomitant left axillary lymph node metastasis. The literature pertaining to clinical presentation, pathological findings and prognosis of such patients has been reviewed. The surgical treatment and adjuvant therapy have been discussed. Patients should be counselled to seek medical advice early for persistent ulcerations or deep scars of burn wounds, especially those overlying joint surfaces.

Adult↗

PubMed1981

The surgical treatment and outcome of soft-tissue sarcoma.

Cases of 251 patients with soft-tissue sarcoma of the extremities, trunk, head and neck, and retroperitoneum were reviewed. The overall five-, ten-, and 15-year survival rates were 45%, 30%, and 24%, respectively. The five-year survival rates after wide soft-tissue resections, local excision, and amputation were 59%, 42%, and 39%, respectively. Factors that significantly affected prognosis were tumor size, histologic type, local extent of the tumor, and the adequacy of the surgical procedure. The local recurrence rate was 36% after wide resection, 8% after amputation, and 65% after local excision. Local recurrence alone was treatable and evidenced overall five- and ten-year survival rates of 43% and 33%, respectively. Amputation was the most effective method to treat local recurrences in the extremities. Some guidelines are suggested to select high-risk patients for adjuvant treatment.

Adolescent↗

PubMed1979

Constant-pressure aortic root perfusion versus cardioplegia and hypothermia. Comparison of methods of myocardial protection.

Both coronary perfusion and hypothermic cardioplegia are widely used methods of myocardial protection during aortic valve replacement. A theoretical objection to coronary perfusion is that it is not synchronized with cardiac contractions. Accordingly, a special pump was designed to provide perfusion at a constant range of pressure. Twenty dogs were studied during 4 hours of bypass. In six dogs no manipulations were carried out and hearts were allowed to beat in a nonworking state. Seven dogs underwent 2 hours of aortic cross-clamping and constant-pressure aortic root perfusion. Seven dogs underwent 2 hours of uninterrupted aortic occlusion with myocardial protection being maintained by cold potassium-induced arrest, Contractility did not change significantly in any of the three groups. All animals demonstrated significant hyperemia after bypass but normal endocardial/epicardial flow ratios. Although compliance deteriorated in all groups, the most striking changes were seen following 4 hours of bypass alone or constant-pressure aortic root perfusion. Hypothermic potassium arrest, in contrast, provided a slightly greater degree of myocardial protection, perhaps both by limiting the degree of ischemic injury directly and by excluding the heart from the circulating blood and the pump oxygenator system.

Animals↗

PubMedDate not supplied

Gastric leiomyosarcoma: a clinicopathologic study.

Seven patients with gastric leiomyosarcoma (LMS) and leiomyoblastoma (LMB) were seen at the American University of Beirut Medical Center in the period 1970-1983. The natural history, clinical presentation, radiologic findings, histopathologic features and treatment modalities of these patients are discussed. The anatomic location of the tumor had no relation to the occurrence and number of mucosal ulcers. Ulcerations were more frequent with endogastric than exogastric tumors. Histologic pattern, cell shape and number of mitotic figures were the basic morphological criteria for differentiating between LMS and LMB. Maintenance of a reasonable gastric reservoir and avoidance of total or near total gastrectomy are important factors affecting long term morbidity following surgical resection.

Adult↗

PubMedDate not supplied

Effectiveness of cisplatin in the treatment of anal squamous cell carcinoma.

The therapeutic activity of cisplatin was explored in three consecutive patients with locoregional squamous cell carcinoma of the anus who received no prior therapy. One complete response and two partial responses were achieved. These data, although preliminary, strongly suggest that this disease is sensitive to cisplatin, and further trials are indicated to assess the precise role of this drug in the overall management of anal carcinoma.

Aged↗

PubMedDate not supplied

Anorectal melanoma: clinical features, recurrence and patient survival.

In this study, 20 cases of anorectal melanoma seen over a 50-year period were analyzed. It is common to mistake this tumor for other benign conditions because of its similar clinical presentation and the frequent absence of pigmentation. Patients with anal lesions had a significantly longer mean survival than those with rectal lesions. Abdominoperineal resection provided patients with a significantly longer survival than did local excision. In spite of radical surgery, recurrence rates were high and were mainly local, hepatic or disseminated. Earlier diagnosis and improved adjuvant treatment may lengthen survival.

Adult↗