The pro-oxidant and antioxidant effects of vitamin C.
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Biomedical subjects
Publications and source records attributed to J S Bland.
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By the year 2020, twenty percent of the US population will be aged 65 years or older. The greatest growth in numbers will be among those aged 85 years or older. If the healthcare demands of this group match those of their parents, it will place an extraordinary burden on funding for medical services. By promoting healthy aging, complementary medicine practitioners can improve the cost-effectiveness of healthcare delivery. A scientifically based complementary medicine program to promote healthy aging includes (1) diet and nutritional tailoring, (2) nutrient enhancement to meet specific individual needs, (3) exercise training, (4) stress management, (5) promotion of structural integrity, (6) environmental adjustment, (7) counseling on purposeful living, and (8) normalizing intercellular communication. The program described in this article incorporates these features and focuses on the following modifiable factors of unhealthy aging: altered mitochondrial function and oxidative stress, increased protein glycation, chronic inflammation, defects in methylation, reduced detoxification ability, and altered immunity.
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All families of plant food are known to contain phytonutrients, that is, unique substances produced during the natural course of plant growth and development that are specific to each plant's genes and environment. The term phytonutrition refers to the role of these substances in cultural food practices and cuisines worldwide in supporting health. In addition to their phytonutritive role, phytonutrients have a phytotherapeutic role, acting as modifiers of physiological function. The consumption of 30 to 50 mg per day of soy isoflavones in the traditional Japanese diet and the ability of this diet to help lower the incidence of breast cancer among Japanese women is an example of phytotherapeutic effect. The dividing line between phytonutrition and phytotherapy has blurred with the discovery that certain food components can not only modify physiological function but also aid in medical practices such as drug delivery. Naringenin, for example, the 4',5',7-hydroxyflavanone found exclusively in grapefruit, can slow hepatic detoxification of prescription drugs like cyclosporine and thus potentially help prevent rejection of transplanted organs. Natural and synthetic phytonutrients may differ significantly in their effect on physiological function owing to stereoisomeric composition. The potential of specific phytochemicals to promote health must be carefully evaluated with the same risk-benefit model traditionally used to assess concentrated levels of any substance placed into the body.
Recent research has led to the evolution of an important clinical relationship among psychology, neurobiochemistry, and nutrition. The result has been the development of the multidisciplinary field of psychoneuro-nutritional medicine. The successful application of this medical model to mental health problems ranging from behavior disorders in children to cognitive/emotional disorders in adults has opened the door to new lower-technology, cost-effective approaches to improving functional neurobiochemistry. This review describes the psychoneuro-nutritional medicine model and its application to a variety of biobehaviorally related health problems.
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"Senile" or age-related bone loss affects cortical and trabecular bone and may be detected in the appendicular as well as the axial skeleton. This study presents radiographic photodensitometry as a precise and sensitive technique for evaluating appendicular skeletal status. Data from reproducibility studies indicate that the coefficient of variation for the technology is between 1.9% and 4.5% for the three bones analyzed. Evaluation of age-related changes in bone mass for over 800 subjects demonstrated a decline in mass vs. age after the fourth decade in women, with the slope of the decline being very similar to that seen in CT longitudinal studies. Applied serially to a patient over time, the technology identifies changes in bone mass and may be used to evaluate the response to intervention therapy.
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