Biomedical subjects

J S Braun

Publications and source records attributed to J S Braun.

At least 19 recordsLinked to original sources

PubMed1988

Measurement of body potassium with a whole-body counter: relationship between lean body mass and resting energy expenditure.

We conducted studies to determine whether the Mayo whole-body counter could be used to measure body potassium, and thus lean body mass (LBM), and whether moderate obesity alters resting energy expenditure when corrected for LBM. Twenty-four nonobese and 18 moderately obese adults underwent body potassium (40K) counting, as well as tritiated water space measurement and indirect calorimetry. LBM values predicted from 40K counting and tritiated water space measurements were highly correlated (P = 0.001; r = 0.88). Resting energy expenditure was closely related to LBM (P less than 0.0001; r = 0.78): kcal/day = 622 kcal + (LBM.20.0 kcal/kg LBM). In this relationship, the obese subjects did not differ from nonobese subjects. In summary, the Mayo whole-body counter can accurately measure LBM, and moderate obesity has no detectable effect on corrected resting energy expenditure.

Adult↗

PubMed1979

[Determination of serum digoxin. A comparison between RIA and EIA (author's transl)].

The results of two radioimmunoassays (RIA, precipitating technique), of a homogenous (EMIT) and a heterogenous (ELISA) enzyme immunoassay (EIA) for ascertaining the amounts of digoxin showed a good correlation in precision and a reasonably satisfying correlation in the recovery. However, there was a clear discrepancy in the amounts of digoxin concentrate in the serum of patients. Only the RIA of Abbott and the EIA of Boehringer showed no significant differences. Particularly noticeable was the tendency towards lower values in the EMIT-technique as well as its liability to unspecific serum changes (lipaemia etc.), which often made the detection of digoxin impossible. The routine use of this technique appears problematic. The need for establishing one's own laboratory and test-specific therapeutical range is pointed out.

Digoxin↗

PubMed1977

[Pre-stained slides for differential blood counts (author's transl)].

A new method for differential blood counts using pre-stained slides showed it to be suitable for routine use. To differentiate white blood cells the same experience was needed as for conventional stainings. Normal and abnormal blood pictures can be reliably distinguished. The particular advantage of the method is in the simple preparation of the smear and in avoiding the need for time-consuming staining.

Blood Cells↗

PubMed1975

[Studies on cerebrospinal fluid diffusion of trimethoprim in children].

Full quantitative fluorometric analysis of TMP in serum and cerebrospinal fluid in 91 infants and children (all anyhow designed for lumbar puncture for other reasons) 1/2 - 12 hours after i. v. injection of TMP in a single dose of 4 mg/kg (73 cases, tab. 1-2, fig. 1) or 12 mg/kg (18 cases, tab. 3, fig. 2). TMP in serum and cerebrospinal fluid showed regularly high plateaus for the whole time investigated, i.e. 12 hours after i. v. injection (fig. 1-2). The c.s.f./serum ratio for TMP (2-12 hours after injection) was 30-40%(fig. 1). After a dose of 12 mg/kg the ratio was even 50% and more (fig. 2). There were - in our material - no differences of the ratio according to c.s.f. state (normal - tab. 1, or pathological-tab. 2), or age. Considerating published data on enteral resorption of trimethoprim-sulfamethoxazole and c.s.f. diffussion of SMZ together with our results, we can expect a very intensifying proportion TMP: SMZ near 1:10 in cerebrospinal fluid after intake of officinal TMP-SMZ (Co-trimoxazol). This might have diagnostic and therapeutic consequences.

Child↗

PubMed1975

[A new rapid test for diagnosing micro-haematuria, compared with results of microscopic examination].

Micro-haematuria may be difficult to diagnose because the usual sediment methods may be inadequate and test strips may in practice not be sensitive enough. The demarcation between normal and pathological RBC excretion is, therefore, not always clearly established. A new test strip (Sangur-Test) has its lower limit of positive results at 1 000 RBC/ml urine and physiological ranges of RBC excretion could be distinguished from micro-haematuria with satisfactory accuracy. Comparative tests of 637 freshly voided urine specimens in routine diagnosis produced no false-negative results and in only a small percentage of cases recorded a higher RBC concentration than the ten-field sediment method.

Blood Sedimentation↗

PubMed1975

[Therapy of the carcinoma of the prostate and case control (III) (Author's transl)].

In a third information of our long-term study with now 304 cases we report on 54 cases with monotherapy-only orchiectomy, only hormones and combination of boths. With it the rectal palpable results have coincided significantly with the histological findings in all 3 therapeutic forms. As for the therapeutic result no difference is to be seen either histological or clinical after a 3 years' observation period. We cannot tell anything now about optimal methods of treatment with regard to the histological starting material. In all 3 therapeutic forms we observed regressions to stage O. The smallest plasma-testosteron concentration was found after orchiectomy, where no increase was recorded during the whole observation period.

Adenocarcinoma↗

PubMed1974