Biomedical subjects
Publications and source records attributed to J S Chapman-Smith.
In this study 146 pterygia were excised from 116 patients. The eyes were treated with Thiotepa eyedrops over four weeks to discourage regrowth. All treatment was carried out by the one surgeon on consecutive patients. The relationship between pinguecula and pterygium is explored, and the pathogenesis of pterygium growth discussed.
Patients who were admitted to Auckland Hospital with an eye injury during 1975 have been considered. The cause of injury, type of injury and visual outcome have been recorded. At least 60 percent of the eye injuries occurred during leisure activities. In this study more patients were admitted with an hyphaema following sports injuries and fewer admitted after motor mower injuries than in an earlier study. Some preventative measures in eye injury are discussed.
The eye injuries resulting from motor vehicle accidents over the three years, 1975 to 1977 inclusive are considered. A high incidence of severe eye injury produced by safety windscreen glass continues. The results of this survey are compared with a survey of the period 1970 to 1974 inclusive.
A new microsurgical system is presented for human and experimental corneal grafting. The system is based on novel methods of corneal cutting and holding which simplify collection procedures and minimise operator manipulation during transplantation.
After preliminary testing with pig, dog, rabbit, monkey, cat, and human cadaver eyes the CLCC system has been used for penetrating and lamellar keratoplasty in human subjects. Clinical experience covers a broad range of corneal pathology. Detailed operative instructions and observations are given. In the experimental situation the CLCC is being used to achieve deep lamellar corneal dissection for a continuing study of non-penetrating keratoplasty.
Chorioretinitis occurred in a young man whose long-standing cryptococcal meningitis had been identified and treated. In one eye spontaneous resolution had occurred. His case history and fluorescein angiograms are presented.
Urokinase is a plasminogen activator of human origin which breaks up the fibrin base of blood clots. When given as an intravitreal injection it produces hypopyon and glaucoma, both of which transient. In a series of 27 patients (34 eyes) with unresolved vitreous haemorrhage, this simple and relatively atraumatic treatment has produced marked objective improvement in 10, and greatly improved the life styles of a further 9. This series brings the total of reported cases to 93. When compared with recent American reports of surgical vitrectomy for vitreous haemorrhage, intravitreal urokinase appears to have a higher success rate, with a lower complication rate both in the short and long term. This study suggests that, despite the high cost of the purified enzyme, urokinase should be come the first line of attack in vitreous haemorrhage, vitrectomy being reserved for those patients who fail to respond.
Short-term corneal storage at a temperature of 4degrees C. was assessed with human cadaver eyes. Aqueous was replaced by air in one of each of 11 pairs of eyes, stored for periods of up to 96 hours post-mortem. The influence of air on the endothelial layer was measured in terms of corneal thickness, trypan blue staining, and scanning electron microscopy. Air-filled eyes developed less corneal edema over the storage period. No significant differences were found between the endothelia of test and control eyes. Degenerative changes in endothelium were documented photographically.
Despite the introduction of compulsory seat belt legislation, the incidence of eye injuries, and their severity, is greater in Auckland, New Zealand, than in London, Canada. A comparison has been made between Auckland (83 cases) and London (50 cases) in a survey from 1 July 1970, to 31 December 1974. Consideration is given to the fact that New Zealand vehicles are equipped with heat-toughened (tempered) glass, whereas in Canada, vehicles are fitted with laminated windscreens.